BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

109 related articles for article (PubMed ID: 19703036)

  • 21. DNA and RNA synthesis: antifolates.
    Kompis IM; Islam K; Then RL
    Chem Rev; 2005 Feb; 105(2):593-620. PubMed ID: 15700958
    [No Abstract]   [Full Text] [Related]  

  • 22. 6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents.
    Gangjee A; Zhu Y; Queener SF
    J Med Chem; 1998 Nov; 41(23):4533-41. PubMed ID: 9804692
    [TBL] [Abstract][Full Text] [Related]  

  • 23. 2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes.
    Piras S; Carta A; Briguglio I; Corona P; Paglietti G; Luciani R; Costi MP; Ferrari S
    Eur J Med Chem; 2014 Mar; 75():169-83. PubMed ID: 24531230
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Structural studies on bioactive compounds. 39. Biological consequences of the structural modification of DHFR-inhibitory 2,4-diamino-6-(4-substituted benzylamino-3-nitrophenyl)-6-ethylpyrimidines ('benzoprims').
    Richardson ML; Croughton KA; Matthews CS; Stevens MF
    J Med Chem; 2004 Jul; 47(16):4105-8. PubMed ID: 15267250
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
    Chan DC; Fu H; Forsch RA; Queener SF; Rosowsky A
    J Med Chem; 2005 Jun; 48(13):4420-31. PubMed ID: 15974594
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Triazine-benzimidazole hybrids: anticancer activity, DNA interaction and dihydrofolate reductase inhibitors.
    Singla P; Luxami V; Paul K
    Bioorg Med Chem; 2015 Apr; 23(8):1691-700. PubMed ID: 25792141
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Design, synthesis and evaluation of antitumor acylated monoaminopyrroloquinazolines.
    Chao B; Li BX; Xiao X
    Bioorg Med Chem Lett; 2017 Jul; 27(14):3107-3110. PubMed ID: 28552339
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.
    Rosowsky A; Forsch RA; Queener SF
    J Med Chem; 2003 Apr; 46(9):1726-36. PubMed ID: 12699390
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Lipoamino acid conjugates of methotrexate with antitumor activity.
    Pignatello R; Jansen G; Kathmann I; Puglisi G; Toth I
    J Pharm Sci; 1998 Mar; 87(3):367-71. PubMed ID: 9523991
    [TBL] [Abstract][Full Text] [Related]  

  • 30. In vitro effects of Plasmodium falciparum dihydrofolate reductase inhibitors on normal and cancer cell proliferation.
    Rossi T; Coppi A; Bruni E; Sgobba M; Degliesposti G; Rastelli G
    ChemMedChem; 2008 Mar; 3(3):421-4. PubMed ID: 17973282
    [No Abstract]   [Full Text] [Related]  

  • 31. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G; Wright JE; Rosowsky A
    Mol Pharmacol; 1995 Oct; 48(4):758-65. PubMed ID: 7476904
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Dicyclic and tricyclic diaminopyrimidine derivatives as potent inhibitors of Cryptosporidium parvum dihydrofolate reductase: structure-activity and structure-selectivity correlations.
    Nelson RG; Rosowsky A
    Antimicrob Agents Chemother; 2001 Dec; 45(12):3293-303. PubMed ID: 11709300
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.
    Bolstad DB; Bolstad ES; Frey KM; Wright DL; Anderson AC
    J Med Chem; 2008 Nov; 51(21):6839-52. PubMed ID: 18834108
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
    Gangjee A; Vidwans AP; Vasudevan A; Queener SF; Kisliuk RL; Cody V; Li R; Galitsky N; Luft JR; Pangborn W
    J Med Chem; 1998 Aug; 41(18):3426-34. PubMed ID: 9719595
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Sanguinarine suppresses basal-like breast cancer growth through dihydrofolate reductase inhibition.
    Kalogris C; Garulli C; Pietrella L; Gambini V; Pucciarelli S; Lucci C; Tilio M; Zabaleta ME; Bartolacci C; Andreani C; Giangrossi M; Iezzi M; Belletti B; Marchini C; Amici A
    Biochem Pharmacol; 2014 Aug; 90(3):226-34. PubMed ID: 24875448
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Synthesis and biological evaluation of nonclassical 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines with novel side chain substituents as potential inhibitors of dihydrofolate reductases.
    Gangjee A; Vasudevan A; Queener SF
    J Med Chem; 1997 Feb; 40(4):479-85. PubMed ID: 9046338
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones.
    Al-Omary FA; Abou-Zeid LA; Nagi MN; Habib el-SE; Abdel-Aziz AA; El-Azab AS; Abdel-Hamide SG; Al-Omar MA; Al-Obaid AM; El-Subbagh HI
    Bioorg Med Chem; 2010 Apr; 18(8):2849-63. PubMed ID: 20350811
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines.
    Gangjee A; Guo X; Queener SF; Cody V; Galitsky N; Luft JR; Pangborn W
    J Med Chem; 1998 Apr; 41(8):1263-71. PubMed ID: 9548816
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.
    Gangjee A; Vasudevan A; Queener SF
    J Med Chem; 1997 Sep; 40(19):3032-9. PubMed ID: 9301665
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Nonclassical antifolates, part 4. 5-(2-aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: synthesis, biological evaluation and molecular modeling study.
    Hassan GS; El-Messery SM; Al-Omary FA; Al-Rashood ST; Shabayek MI; Abulfadl YS; Habib el-SE; El-Hallouty SM; Fayad W; Mohamed KM; El-Menshawi BS; El-Subbagh HI
    Eur J Med Chem; 2013 Aug; 66():135-45. PubMed ID: 23792351
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 6.