BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

276 related articles for article (PubMed ID: 19703768)

  • 1. Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA).
    West CW; Adler M; Arnaiz D; Chen D; Chu K; Gualtieri G; Ho E; Huwe C; Light D; Phillips G; Pulk R; Sukovich D; Whitlow M; Yuan S; Bryant J
    Bioorg Med Chem Lett; 2009 Oct; 19(19):5712-5. PubMed ID: 19703768
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator.
    Frederickson M; Callaghan O; Chessari G; Congreve M; Cowan SR; Matthews JE; McMenamin R; Smith DM; Vinković M; Wallis NG
    J Med Chem; 2008 Jan; 51(2):183-6. PubMed ID: 18163548
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis.
    Islam I; Yuan S; West CW; Adler M; Bothe U; Bryant J; Chang Z; Chu K; Emayan K; Gualtieri G; Ho E; Light D; Mallari C; Morser J; Phillips G; Schaefer C; Sukovich D; Whitlow M; Chen D; Buckman BO
    Bioorg Med Chem Lett; 2018 Nov; 28(20):3372-3375. PubMed ID: 30201291
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular basis of specific inhibition of urokinase plasminogen activator by amiloride.
    Jankun J; Skrzypczak-Jankun E
    Cancer Biochem Biophys; 1999 Jul; 17(1-2):109-23. PubMed ID: 10738907
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.
    Wendt MD; Rockway TW; Geyer A; McClellan W; Weitzberg M; Zhao X; Mantei R; Nienaber VL; Stewart K; Klinghofer V; Giranda VL
    J Med Chem; 2004 Jan; 47(2):303-24. PubMed ID: 14711304
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines.
    Barber CG; Dickinson RP; Fish PV
    Bioorg Med Chem Lett; 2004 Jun; 14(12):3227-30. PubMed ID: 15149680
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.
    Spencer JR; McGee D; Allen D; Katz BA; Luong C; Sendzik M; Squires N; Mackman RL
    Bioorg Med Chem Lett; 2002 Aug; 12(15):2023-6. PubMed ID: 12113833
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors.
    Wendt MD; Geyer A; McClellan WJ; Rockway TW; Weitzberg M; Zhao X; Mantei R; Stewart K; Nienaber V; Klinghofer V; Giranda VL
    Bioorg Med Chem Lett; 2004 Jun; 14(12):3063-8. PubMed ID: 15149645
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.
    Mackman RL; Hui HC; Breitenbucher JG; Katz BA; Luong C; Martelli A; McGee D; Radika K; Sendzik M; Spencer JR; Sprengeler PA; Tario J; Verner E; Wang J
    Bioorg Med Chem Lett; 2002 Aug; 12(15):2019-22. PubMed ID: 12113832
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
    Katz BA; Luong C; Ho JD; Somoza JR; Gjerstad E; Tang J; Williams SR; Verner E; Mackman RL; Young WB; Sprengeler PA; Chan H; Mortara K; Janc JW; McGrath ME
    J Mol Biol; 2004 Nov; 344(2):527-47. PubMed ID: 15522303
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.
    Katz BA; Sprengeler PA; Luong C; Verner E; Elrod K; Kirtley M; Janc J; Spencer JR; Breitenbucher JG; Hui H; McGee D; Allen D; Martelli A; Mackman RL
    Chem Biol; 2001 Nov; 8(11):1107-21. PubMed ID: 11731301
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Species specificity of amidine-based urokinase inhibitors.
    Klinghofer V; Stewart K; McGonigal T; Smith R; Sarthy A; Nienaber V; Butler C; Dorwin S; Richardson P; Weitzberg M; Wendt M; Rockway T; Zhao X; Hulkower KI; Giranda VL
    Biochemistry; 2001 Aug; 40(31):9125-31. PubMed ID: 11478879
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors.
    Zeslawska E; Jacob U; Schweinitz A; Coombs G; Bode W; Madison E
    J Mol Biol; 2003 Apr; 328(1):109-18. PubMed ID: 12684001
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines.
    Fish PV; Barber CG; Brown DG; Butt R; Collis MG; Dickinson RP; Henry BT; Horne VA; Huggins JP; King E; O'Gara M; McCleverty D; McIntosh F; Phillips C; Webster R
    J Med Chem; 2007 May; 50(10):2341-51. PubMed ID: 17447747
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 2-Amidino analogs of glycine-amiloride conjugates: inhibitors of urokinase-type plasminogen activator.
    Massey AP; Harley WR; Pasupuleti N; Gorin FA; Nantz MH
    Bioorg Med Chem Lett; 2012 Apr; 22(7):2635-9. PubMed ID: 22366654
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
    Katz BA; Mackman R; Luong C; Radika K; Martelli A; Sprengeler PA; Wang J; Chan H; Wong L
    Chem Biol; 2000 Apr; 7(4):299-312. PubMed ID: 10779411
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.
    Verner E; Katz BA; Spencer JR; Allen D; Hataye J; Hruzewicz W; Hui HC; Kolesnikov A; Li Y; Luong C; Martelli A; Radika K; Rai R; She M; Shrader W; Sprengeler PA; Trapp S; Wang J; Young WB; Mackman RL
    J Med Chem; 2001 Aug; 44(17):2753-71. PubMed ID: 11495587
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The crystal structures of 3-TAPAP in complexes with the urokinase-type plasminogen activator and picrate.
    Zesławska E; Jacob U; Stürzebecher J; Oleksyn BJ
    Bioorg Med Chem Lett; 2006 Jan; 16(1):228-34. PubMed ID: 16202591
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of trypsin and urokinase by Cbz-amino(4-guanidinophenyl)methanephosphonate aromatic ester derivatives: the influence of the ester group on their biological activity.
    Sieńczyk M; Oleksyszyn J
    Bioorg Med Chem Lett; 2006 Jun; 16(11):2886-90. PubMed ID: 16546384
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA).
    Venkatraj M; Messagie J; Joossens J; Lambeir AM; Haemers A; Van der Veken P; Augustyns K
    Bioorg Med Chem; 2012 Feb; 20(4):1557-68. PubMed ID: 22285569
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.