579 related articles for article (PubMed ID: 19727074)
1. A dimerization-dependent mechanism drives RAF catalytic activation.
Rajakulendran T; Sahmi M; Lefrançois M; Sicheri F; Therrien M
Nature; 2009 Sep; 461(7263):542-5. PubMed ID: 19727074
[TBL] [Abstract][Full Text] [Related]
2. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
Brennan DF; Dar AC; Hertz NT; Chao WC; Burlingame AL; Shokat KM; Barford D
Nature; 2011 Apr; 472(7343):366-9. PubMed ID: 21441910
[TBL] [Abstract][Full Text] [Related]
3. MEK drives BRAF activation through allosteric control of KSR proteins.
Lavoie H; Sahmi M; Maisonneuve P; Marullo SA; Thevakumaran N; Jin T; Kurinov I; Sicheri F; Therrien M
Nature; 2018 Feb; 554(7693):549-553. PubMed ID: 29433126
[TBL] [Abstract][Full Text] [Related]
4. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
Hatzivassiliou G; Song K; Yen I; Brandhuber BJ; Anderson DJ; Alvarado R; Ludlam MJ; Stokoe D; Gloor SL; Vigers G; Morales T; Aliagas I; Liu B; Sideris S; Hoeflich KP; Jaiswal BS; Seshagiri S; Koeppen H; Belvin M; Friedman LS; Malek S
Nature; 2010 Mar; 464(7287):431-5. PubMed ID: 20130576
[TBL] [Abstract][Full Text] [Related]
5. RAF protein-serine/threonine kinases: structure and regulation.
Roskoski R
Biochem Biophys Res Commun; 2010 Aug; 399(3):313-7. PubMed ID: 20674547
[TBL] [Abstract][Full Text] [Related]
6. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
Poulikakos PI; Zhang C; Bollag G; Shokat KM; Rosen N
Nature; 2010 Mar; 464(7287):427-30. PubMed ID: 20179705
[TBL] [Abstract][Full Text] [Related]
7. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.
Hu J; Yu H; Kornev AP; Zhao J; Filbert EL; Taylor SS; Shaw AS
Proc Natl Acad Sci U S A; 2011 Apr; 108(15):6067-72. PubMed ID: 21441104
[TBL] [Abstract][Full Text] [Related]
8. Regulation and role of Raf-1/B-Raf heterodimerization.
Rushworth LK; Hindley AD; O'Neill E; Kolch W
Mol Cell Biol; 2006 Mar; 26(6):2262-72. PubMed ID: 16508002
[TBL] [Abstract][Full Text] [Related]
9. Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.
Garnett MJ; Rana S; Paterson H; Barford D; Marais R
Mol Cell; 2005 Dec; 20(6):963-9. PubMed ID: 16364920
[TBL] [Abstract][Full Text] [Related]
10. RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKα.
Varga A; Ehrenreiter K; Aschenbrenner B; Kocieniewski P; Kochanczyk M; Lipniacki T; Baccarini M
Sci Signal; 2017 Mar; 10(469):. PubMed ID: 28270557
[TBL] [Abstract][Full Text] [Related]
11. Allosteric activation of functionally asymmetric RAF kinase dimers.
Hu J; Stites EC; Yu H; Germino EA; Meharena HS; Stork PJS; Kornev AP; Taylor SS; Shaw AS
Cell; 2013 Aug; 154(5):1036-1046. PubMed ID: 23993095
[TBL] [Abstract][Full Text] [Related]
12. Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF.
Baljuls A; Dobrzyński M; Rauch J; Rauch N; Kolch W
Cell Signal; 2016 Oct; 28(10):1451-62. PubMed ID: 27368419
[TBL] [Abstract][Full Text] [Related]
13. A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila.
Douziech M; Sahmi M; Laberge G; Therrien M
Genes Dev; 2006 Apr; 20(7):807-19. PubMed ID: 16600912
[TBL] [Abstract][Full Text] [Related]
14. Ras-mutant cancer cells display B-Raf binding to Ras that activates extracellular signal-regulated kinase and is inhibited by protein kinase A phosphorylation.
Li Y; Takahashi M; Stork PJS
J Biol Chem; 2013 Sep; 288(38):27646-27657. PubMed ID: 23893412
[TBL] [Abstract][Full Text] [Related]
15. Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites.
Ory S; Zhou M; Conrads TP; Veenstra TD; Morrison DK
Curr Biol; 2003 Aug; 13(16):1356-64. PubMed ID: 12932319
[TBL] [Abstract][Full Text] [Related]
16. KSR is a scaffold required for activation of the ERK/MAPK module.
Roy F; Laberge G; Douziech M; Ferland-McCollough D; Therrien M
Genes Dev; 2002 Feb; 16(4):427-38. PubMed ID: 11850406
[TBL] [Abstract][Full Text] [Related]
17. Mechanisms of regulating the Raf kinase family.
Chong H; Vikis HG; Guan KL
Cell Signal; 2003 May; 15(5):463-9. PubMed ID: 12639709
[TBL] [Abstract][Full Text] [Related]
18. Analyses of the oncogenic BRAF
Cope NJ; Novak B; Liu Z; Cavallo M; Gunderwala AY; Connolly M; Wang Z
J Biol Chem; 2020 Feb; 295(8):2407-2420. PubMed ID: 31929109
[TBL] [Abstract][Full Text] [Related]
19. Targeting oncogenic Raf protein-serine/threonine kinases in human cancers.
Roskoski R
Pharmacol Res; 2018 Sep; 135():239-258. PubMed ID: 30118796
[TBL] [Abstract][Full Text] [Related]
20. N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence.
Wang Z; Liu Y; Takahashi M; Van Hook K; Kampa-Schittenhelm KM; Sheppard BC; Sears RC; Stork PJ; Lopez CD
Proc Natl Acad Sci U S A; 2013 Jan; 110(1):312-7. PubMed ID: 23248303
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
