133 related articles for article (PubMed ID: 19760690)
1. Making epothilones fluoresce: design, synthesis, and biological characterization of a fluorescent N12-aza-epothilone (azathilone).
Gertsch J; Feyen F; Bützberger A; Gerber B; Pfeiffer B; Altmann KH
Chembiochem; 2009 Oct; 10(15):2513-21. PubMed ID: 19760690
[TBL] [Abstract][Full Text] [Related]
2. Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization.
Feyen F; Cachoux F; Gertsch J; Wartmann M; Altmann KH
Acc Chem Res; 2008 Jan; 41(1):21-31. PubMed ID: 18159935
[TBL] [Abstract][Full Text] [Related]
3. Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).
Jantsch A; Nieto L; Gertsch J; Rodríguez-Salarichs J; Matesanz R; Jiménez-Barbero J; Díaz JF; Canales Á; Altmann KH
Molecules; 2016 Aug; 21(8):. PubMed ID: 27527129
[TBL] [Abstract][Full Text] [Related]
4. Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin.
Dietrich SA; Lindauer R; Stierlin C; Gertsch J; Matesanz R; Notararigo S; Díaz JF; Altmann KH
Chemistry; 2009 Oct; 15(39):10144-57. PubMed ID: 19697384
[TBL] [Abstract][Full Text] [Related]
5. The binding mode of side chain- and C3-modified epothilones to tubulin.
Erdélyi M; Navarro-Vázquez A; Pfeiffer B; Kuzniewski CN; Felser A; Widmer T; Gertsch J; Pera B; Díaz JF; Altmann KH; Carlomagno T
ChemMedChem; 2010 Jun; 5(6):911-20. PubMed ID: 20432490
[TBL] [Abstract][Full Text] [Related]
6. Differential effects of natural product microtubule stabilizers on microtubule assembly: single agent and combination studies with taxol, epothilone B, and discodermolide.
Gertsch J; Meier S; Müller M; Altmann KH
Chembiochem; 2009 Jan; 10(1):166-75. PubMed ID: 19058273
[TBL] [Abstract][Full Text] [Related]
7. Scaffolds for microtubule inhibition through extensive modification of the epothilone template.
Cachoux F; Isarno T; Wartmann M; Altmann KH
Angew Chem Int Ed Engl; 2005 Dec; 44(45):7469-73. PubMed ID: 16240301
[No Abstract] [Full Text] [Related]
8. Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity.
Feyen F; Gertsch J; Wartmann M; Altmann KH
Angew Chem Int Ed Engl; 2006 Sep; 45(35):5880-5. PubMed ID: 16871640
[No Abstract] [Full Text] [Related]
9. Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.
Pfeiffer B; Hauenstein K; Merz P; Gertsch J; Altmann KH
Bioorg Med Chem Lett; 2009 Jul; 19(14):3760-3. PubMed ID: 19433359
[TBL] [Abstract][Full Text] [Related]
10. Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity.
Acharya BR; Choudhury D; Das A; Chakrabarti G
Biochemistry; 2009 Jul; 48(29):6963-74. PubMed ID: 19527023
[TBL] [Abstract][Full Text] [Related]
11. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography.
Nettles JH; Li H; Cornett B; Krahn JM; Snyder JP; Downing KH
Science; 2004 Aug; 305(5685):866-9. PubMed ID: 15297674
[TBL] [Abstract][Full Text] [Related]
12. Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.
Taliani S; Da Pozzo E; Bellandi M; Bendinelli S; Pugliesi I; Simorini F; La Motta C; Salerno S; Marini AM; Da Settimo F; Cosimelli B; Greco G; Novellino E; Martini C
J Med Chem; 2010 May; 53(10):4085-93. PubMed ID: 20438080
[TBL] [Abstract][Full Text] [Related]
13. Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity.
Buey RM; Díaz JF; Andreu JM; O'Brate A; Giannakakou P; Nicolaou KC; Sasmal PK; Ritzén A; Namoto K
Chem Biol; 2004 Feb; 11(2):225-36. PubMed ID: 15123284
[TBL] [Abstract][Full Text] [Related]
14. Five new epothilone metabolites from Sorangium cellulosum strain So0157-2.
Wang J; Zhang H; Ying L; Wang C; Jiang N; Zhou Y; Wang H; Bai H
J Antibiot (Tokyo); 2009 Sep; 62(9):483-7. PubMed ID: 19575038
[TBL] [Abstract][Full Text] [Related]
15. A fluorescent analog of colcemid, N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-colcemid, as a probe for the colcemid-binding sites of tubulin and microtubules.
Hiratsuka T; Kato T
J Biol Chem; 1987 May; 262(13):6318-22. PubMed ID: 3571259
[TBL] [Abstract][Full Text] [Related]
16. Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition.
Cachoux F; Isarno T; Wartmann M; Altmann KH
Chembiochem; 2006 Jan; 7(1):54-7. PubMed ID: 16345113
[No Abstract] [Full Text] [Related]
17. Computational study of binding of epothilone A to β-tubulin.
Kamel K; Kolinski A
Acta Biochim Pol; 2011; 58(2):255-60. PubMed ID: 21633729
[TBL] [Abstract][Full Text] [Related]
18. Preclinical discovery of ixabepilone, a highly active antineoplastic agent.
Lee FY; Borzilleri R; Fairchild CR; Kamath A; Smykla R; Kramer R; Vite G
Cancer Chemother Pharmacol; 2008 Dec; 63(1):157-66. PubMed ID: 18347795
[TBL] [Abstract][Full Text] [Related]
19. Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.
Madiraju C; Edler MC; Hamel E; Raccor BS; Balachandran R; Zhu G; Giuliano KA; Vogt A; Shin Y; Fournier JH; Fukui Y; Brückner AM; Curran DP; Day BW
Biochemistry; 2005 Nov; 44(45):15053-63. PubMed ID: 16274252
[TBL] [Abstract][Full Text] [Related]
20. Molecular recognition of epothilones by microtubules and tubulin dimers revealed by biochemical and NMR approaches.
Canales A; Nieto L; Rodríguez-Salarichs J; Sánchez-Murcia PA; Coderch C; Cortés-Cabrera A; Paterson I; Carlomagno T; Gago F; Andreu JM; Altmann KH; Jiménez-Barbero J; Díaz JF
ACS Chem Biol; 2014 Apr; 9(4):1033-43. PubMed ID: 24524625
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]