BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

166 related articles for article (PubMed ID: 19773175)

  • 1. 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization.
    Sander K; Kottke T; Tanrikulu Y; Proschak E; Weizel L; Schneider EH; Seifert R; Schneider G; Stark H
    Bioorg Med Chem; 2009 Oct; 17(20):7186-96. PubMed ID: 19773175
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Receptor-specific functional efficacies of alkyl imidazoles as dual histamine H3/H4 receptor ligands.
    Kottke T; Sander K; Weizel L; Schneider EH; Seifert R; Stark H
    Eur J Pharmacol; 2011 Mar; 654(3):200-8. PubMed ID: 21237145
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor.
    Deml KF; Beermann S; Neumann D; Strasser A; Seifert R
    Mol Pharmacol; 2009 Nov; 76(5):1019-30. PubMed ID: 19720730
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands.
    Schneider EH; Strasser A; Thurmond RL; Seifert R
    J Pharmacol Exp Ther; 2010 Aug; 334(2):513-21. PubMed ID: 20484153
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Lead identification and optimization of diaminopyrimidines as histamine H4 receptor ligands.
    Sander K; Kottke T; Proschak E; Tanrikulu Y; Schneider EH; Seifert R; Schneider G; Stark H
    Inflamm Res; 2010 Mar; 59 Suppl 2():S249-51. PubMed ID: 20012148
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Piperazine modification in 2,4,6-triaminopyrimidine derivatives as histamine H4 receptor ligands.
    Schreeb A; Walter M; Odadzic D; Schwed JS; Weizel L; Stark H
    Pharmazie; 2013 Jul; 68(7):521-5. PubMed ID: 23923631
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.
    Smits RA; Lim HD; Hanzer A; Zuiderveld OP; Guaita E; Adami M; Coruzzi G; Leurs R; de Esch IJ
    J Med Chem; 2008 Apr; 51(8):2457-67. PubMed ID: 18357976
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening.
    Kiss R; Kiss B; Könczöl A; Szalai F; Jelinek I; László V; Noszál B; Falus A; Keseru GM
    J Med Chem; 2008 Jun; 51(11):3145-53. PubMed ID: 18459760
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function.
    Govoni M; Lim HD; El-Atmioui D; Menge WM; Timmerman H; Bakker RA; Leurs R; De Esch IJ
    J Med Chem; 2006 Apr; 49(8):2549-57. PubMed ID: 16610798
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Histamine H(4) receptor-RGS fusion proteins expressed in Sf9 insect cells: a sensitive and reliable approach for the functional characterization of histamine H(4) receptor ligands.
    Schneider EH; Seifert R
    Biochem Pharmacol; 2009 Sep; 78(6):607-16. PubMed ID: 19464266
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and evaluation of novel ligands for the histamine H₄ receptor based on a pyrrolo[2,3-d]pyrimidine scaffold.
    Gao LJ; Schwed JS; Weizel L; De Jonghe S; Stark H; Herdewijn P
    Bioorg Med Chem Lett; 2013 Jan; 23(1):132-7. PubMed ID: 23218604
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands.
    Lee-Dutra A; Arienti KL; Buzard DJ; Hack MD; Khatuya H; Desai PJ; Nguyen S; Thurmond RL; Karlsson L; Edwards JP; Breitenbucher JG
    Bioorg Med Chem Lett; 2006 Dec; 16(23):6043-8. PubMed ID: 16990005
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands.
    Savall BM; Edwards JP; Venable JD; Buzard DJ; Thurmond R; Hack M; McGovern P
    Bioorg Med Chem Lett; 2010 Jun; 20(11):3367-71. PubMed ID: 20452213
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Major advances in the development of histamine H4 receptor ligands.
    Smits RA; Leurs R; de Esch IJ
    Drug Discov Today; 2009 Aug; 14(15-16):745-53. PubMed ID: 19477292
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In silico characterization of ligand binding modes in the human histamine H4 receptor and their impact on receptor activation.
    Werner T; Sander K; Tanrikulu Y; Kottke T; Proschak E; Stark H; Schneider G
    Chembiochem; 2010 Sep; 11(13):1850-5. PubMed ID: 20665769
    [No Abstract]   [Full Text] [Related]  

  • 16. Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.
    Lim HD; Istyastono EP; van de Stolpe A; Romeo G; Gobbi S; Schepers M; Lahaye R; Menge WM; Zuiderveld OP; Jongejan A; Smits RA; Bakker RA; Haaksma EE; Leurs R; de Esch IJ
    Bioorg Med Chem; 2009 Jun; 17(11):3987-94. PubMed ID: 19414267
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor-H1/H4-receptor selectivity.
    Hammer SG; Gobleder S; Naporra F; Wittmann HJ; Elz S; Heinrich MR; Strasser A
    Bioorg Med Chem Lett; 2016 Jan; 26(2):292-300. PubMed ID: 26718844
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity.
    Wijtmans M; de Graaf C; de Kloe G; Istyastono EP; Smit J; Lim H; Boonnak R; Nijmeijer S; Smits RA; Jongejan A; Zuiderveld O; de Esch IJ; Leurs R
    J Med Chem; 2011 Mar; 54(6):1693-703. PubMed ID: 21348462
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.
    Kobayashi T; Watanabe M; Yoshida A; Yamada S; Ito M; Abe H; Ito Y; Arisawa M; Shuto S
    Bioorg Med Chem; 2010 Feb; 18(3):1076-82. PubMed ID: 20045649
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Histamine H4 receptor agonists.
    Igel P; Dove S; Buschauer A
    Bioorg Med Chem Lett; 2010 Dec; 20(24):7191-9. PubMed ID: 21044842
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.