278 related articles for article (PubMed ID: 19775282)
41. Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma.
Plentz R; Park JS; Rhim AD; Abravanel D; Hezel AF; Sharma SV; Gurumurthy S; Deshpande V; Kenific C; Settleman J; Majumder PK; Stanger BZ; Bardeesy N
Gastroenterology; 2009 May; 136(5):1741-9.e6. PubMed ID: 19208345
[TBL] [Abstract][Full Text] [Related]
42. Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises.
Sarmento LM; Barata JT
Expert Rev Anticancer Ther; 2011 Sep; 11(9):1403-15. PubMed ID: 21929314
[TBL] [Abstract][Full Text] [Related]
43. Therapeutic antibody targeting of individual Notch receptors.
Wu Y; Cain-Hom C; Choy L; Hagenbeek TJ; de Leon GP; Chen Y; Finkle D; Venook R; Wu X; Ridgway J; Schahin-Reed D; Dow GJ; Shelton A; Stawicki S; Watts RJ; Zhang J; Choy R; Howard P; Kadyk L; Yan M; Zha J; Callahan CA; Hymowitz SG; Siebel CW
Nature; 2010 Apr; 464(7291):1052-7. PubMed ID: 20393564
[TBL] [Abstract][Full Text] [Related]
44. FHL1C induces apoptosis in Notch1-dependent T-ALL cells through an interaction with RBP-J.
Fu W; Wang K; Zhao JL; Yu HC; Li SZ; Lin Y; Liang L; Huang SY; Liang YM; Han H; Qin HY
BMC Cancer; 2014 Jun; 14():463. PubMed ID: 24952875
[TBL] [Abstract][Full Text] [Related]
45. γ-Secretase inhibitor I induces apoptosis in chronic lymphocytic leukemia cells by proteasome inhibition, endoplasmic reticulum stress increase and notch down-regulation.
Rosati E; Sabatini R; De Falco F; Del Papa B; Falzetti F; Di Ianni M; Cavalli L; Fettucciari K; Bartoli A; Screpanti I; Marconi P
Int J Cancer; 2013 Apr; 132(8):1940-53. PubMed ID: 23001755
[TBL] [Abstract][Full Text] [Related]
46. PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia.
Govaerts I; Prieto C; Vandersmissen C; Gielen O; Jacobs K; Provost S; Nittner D; Maertens J; Boeckx N; De Keersmaecker K; Segers H; Cools J
J Hematol Oncol; 2021 Jun; 14(1):97. PubMed ID: 34167562
[TBL] [Abstract][Full Text] [Related]
47. Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma.
Cook N; Frese KK; Bapiro TE; Jacobetz MA; Gopinathan A; Miller JL; Rao SS; Demuth T; Howat WJ; Jodrell DI; Tuveson DA
J Exp Med; 2012 Mar; 209(3):437-44. PubMed ID: 22351932
[TBL] [Abstract][Full Text] [Related]
48. γ-Secretase inhibitor I inhibits neuroblastoma cells, with NOTCH and the proteasome among its targets.
Dorneburg C; Goß AV; Fischer M; Roels F; Barth TF; Berthold F; Kappler R; Oswald F; Siveke JT; Molenaar JJ; Debatin KM; Beltinger C
Oncotarget; 2016 Sep; 7(39):62799-62813. PubMed ID: 27588497
[TBL] [Abstract][Full Text] [Related]
49. Preclinical analysis of the γ-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia.
Samon JB; Castillo-Martin M; Hadler M; Ambesi-Impiobato A; Paietta E; Racevskis J; Wiernik PH; Rowe JM; Jakubczak J; Randolph S; Cordon-Cardo C; Ferrando AA
Mol Cancer Ther; 2012 Jul; 11(7):1565-75. PubMed ID: 22504949
[TBL] [Abstract][Full Text] [Related]
50. Inhibition of the NOTCH and mTOR pathways by nelfinavir as a novel treatment for T cell acute lymphoblastic leukemia.
Chang YS; Gills JJ; Kawabata S; Onozawa M; Della Gatta G; Ferrando AA; Aplan PD; Dennis PA
Int J Oncol; 2023 Nov; 63(5):. PubMed ID: 37800623
[TBL] [Abstract][Full Text] [Related]
51. The role of NOTCH1 signaling in T-ALL.
Ferrando AA
Hematology Am Soc Hematol Educ Program; 2009; ():353-61. PubMed ID: 20008221
[TBL] [Abstract][Full Text] [Related]
52. The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia.
Mendes RD; Canté-Barrett K; Pieters R; Meijerink JP
Haematologica; 2016 Sep; 101(9):1010-7. PubMed ID: 27582570
[TBL] [Abstract][Full Text] [Related]
53. [Inhibitory effects of gamma secretase inhibitor on human multiple myeloma xenograft mouse model].
Liu QQ; Liu JL; Guo DM; Teng QL
Zhonghua Xue Ye Xue Za Zhi; 2013 Sep; 34(9):794-7. PubMed ID: 24103879
[TBL] [Abstract][Full Text] [Related]
54. Inhibition of Notch signaling pathway using γ-secretase inhibitor delivered by a low dose of Triton-X100 in cultured oral cancer cells.
Nasrin A; Hassan M; Ye P
Biochem Biophys Res Commun; 2018 Jan; 495(3):2118-2124. PubMed ID: 29253571
[TBL] [Abstract][Full Text] [Related]
55. A novel triazole, NMK-T-057, induces autophagic cell death in breast cancer cells by inhibiting γ-secretase-mediated activation of Notch signaling.
Das A; Narayanam MK; Paul S; Mukhnerjee P; Ghosh S; Dastidar DG; Chakrabarty S; Ganguli A; Basu B; Pal M; Chatterji U; Banerjee SK; Karmakar P; Kumar D; Chakrabarti G
J Biol Chem; 2019 Apr; 294(17):6733-6750. PubMed ID: 30824542
[TBL] [Abstract][Full Text] [Related]
56. Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer.
Kondratyev M; Kreso A; Hallett RM; Girgis-Gabardo A; Barcelon ME; Ilieva D; Ware C; Majumder PK; Hassell JA
Oncogene; 2012 Jan; 31(1):93-103. PubMed ID: 21666715
[TBL] [Abstract][Full Text] [Related]
57. NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity.
Armstrong F; Brunet de la Grange P; Gerby B; Rouyez MC; Calvo J; Fontenay M; Boissel N; Dombret H; Baruchel A; Landman-Parker J; Roméo PH; Ballerini P; Pflumio F
Blood; 2009 Feb; 113(8):1730-40. PubMed ID: 18984862
[TBL] [Abstract][Full Text] [Related]
58. Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors.
Silva A; Jotta PY; Silveira AB; Ribeiro D; Brandalise SR; Yunes JA; Barata JT
Haematologica; 2010 Apr; 95(4):674-8. PubMed ID: 20015880
[TBL] [Abstract][Full Text] [Related]
59. The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia.
Durinck K; Wallaert A; Van de Walle I; Van Loocke W; Volders PJ; Vanhauwaert S; Geerdens E; Benoit Y; Van Roy N; Poppe B; Soulier J; Cools J; Mestdagh P; Vandesompele J; Rondou P; Van Vlierberghe P; Taghon T; Speleman F
Haematologica; 2014 Dec; 99(12):1808-16. PubMed ID: 25344525
[TBL] [Abstract][Full Text] [Related]
60. Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.
Medyouf H; Gao X; Armstrong F; Gusscott S; Liu Q; Gedman AL; Matherly LH; Schultz KR; Pflumio F; You MJ; Weng AP
Blood; 2010 Feb; 115(6):1175-84. PubMed ID: 20008304
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
