These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 19781641)

  • 1. The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
    Li Y; Dunn L; Greggio E; Krumm B; Jackson GS; Cookson MR; Lewis PA; Deng J
    Biochim Biophys Acta; 2009 Dec; 1792(12):1194-7. PubMed ID: 19781641
    [TBL] [Abstract][Full Text] [Related]  

  • 2. LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.
    Taymans JM; Vancraenenbroeck R; Ollikainen P; Beilina A; Lobbestael E; De Maeyer M; Baekelandt V; Cookson MR
    PLoS One; 2011; 6(8):e23207. PubMed ID: 21858031
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The R1441C mutation of LRRK2 disrupts GTP hydrolysis.
    Lewis PA; Greggio E; Beilina A; Jain S; Baker A; Cookson MR
    Biochem Biophys Res Commun; 2007 Jun; 357(3):668-71. PubMed ID: 17442267
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity.
    Guo L; Gandhi PN; Wang W; Petersen RB; Wilson-Delfosse AL; Chen SG
    Exp Cell Res; 2007 Oct; 313(16):3658-70. PubMed ID: 17706965
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.
    Li X; Tan YC; Poulose S; Olanow CW; Huang XY; Yue Z
    J Neurochem; 2007 Oct; 103(1):238-47. PubMed ID: 17623048
    [TBL] [Abstract][Full Text] [Related]  

  • 6. GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.
    Biosa A; Trancikova A; Civiero L; Glauser L; Bubacco L; Greggio E; Moore DJ
    Hum Mol Genet; 2013 Mar; 22(6):1140-56. PubMed ID: 23241358
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain.
    Liao J; Wu CX; Burlak C; Zhang S; Sahm H; Wang M; Zhang ZY; Vogel KW; Federici M; Riddle SM; Nichols RJ; Liu D; Cookson MR; Stone TA; Hoang QQ
    Proc Natl Acad Sci U S A; 2014 Mar; 111(11):4055-60. PubMed ID: 24591621
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The Parkinson's disease-associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2.
    Huang X; Wu C; Park Y; Long X; Hoang QQ; Liao J
    FASEB J; 2019 Apr; 33(4):4814-4823. PubMed ID: 30592623
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.
    Muda K; Bertinetti D; Gesellchen F; Hermann JS; von Zweydorf F; Geerlof A; Jacob A; Ueffing M; Gloeckner CJ; Herberg FW
    Proc Natl Acad Sci U S A; 2014 Jan; 111(1):E34-43. PubMed ID: 24351927
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties.
    Mills RD; Liang LY; Lio DS; Mok YF; Mulhern TD; Cao G; Griffin M; Kenche VB; Culvenor JG; Cheng HC
    J Neurochem; 2018 Nov; 147(3):409-428. PubMed ID: 30091236
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation.
    Greene ID; Mastaglia F; Meloni BP; West KA; Chieng J; Mitchell CJ; Gai WP; Boulos S
    J Neurosci Res; 2014 Apr; 92(4):506-16. PubMed ID: 24375786
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Revisiting the Roco G-protein cycle.
    Terheyden S; Ho FY; Gilsbach BK; Wittinghofer A; Kortholt A
    Biochem J; 2015 Jan; 465(1):139-47. PubMed ID: 25317655
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.
    Deng J; Lewis PA; Greggio E; Sluch E; Beilina A; Cookson MR
    Proc Natl Acad Sci U S A; 2008 Feb; 105(5):1499-504. PubMed ID: 18230735
    [TBL] [Abstract][Full Text] [Related]  

  • 14. LRRK2 autophosphorylation enhances its GTPase activity.
    Liu Z; Mobley JA; DeLucas LJ; Kahn RA; West AB
    FASEB J; 2016 Jan; 30(1):336-47. PubMed ID: 26396237
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro.
    Liu Z; West AB
    Biochim Biophys Acta Proteins Proteom; 2017 Mar; 1865(3):274-280. PubMed ID: 27939437
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.
    Daniëls V; Vancraenenbroeck R; Law BM; Greggio E; Lobbestael E; Gao F; De Maeyer M; Cookson MR; Harvey K; Baekelandt V; Taymans JM
    J Neurochem; 2011 Jan; 116(2):304-15. PubMed ID: 21073465
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.
    Sancho RM; Law BM; Harvey K
    Hum Mol Genet; 2009 Oct; 18(20):3955-68. PubMed ID: 19625296
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules.
    Gandhi PN; Wang X; Zhu X; Chen SG; Wilson-Delfosse AL
    J Neurosci Res; 2008 Jun; 86(8):1711-20. PubMed ID: 18214993
    [TBL] [Abstract][Full Text] [Related]  

  • 19. GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.
    Ito G; Okai T; Fujino G; Takeda K; Ichijo H; Katada T; Iwatsubo T
    Biochemistry; 2007 Feb; 46(5):1380-8. PubMed ID: 17260967
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics.
    Wu CX; Liao J; Park Y; Reed X; Engel VA; Hoang NC; Takagi Y; Johnson SM; Wang M; Federici M; Nichols RJ; Sanishvili R; Cookson MR; Hoang QQ
    J Biol Chem; 2019 Apr; 294(15):5907-5913. PubMed ID: 30796162
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.