202 related articles for article (PubMed ID: 19795888)
1. Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors.
Park KD; Morieux P; Salomé C; Cotten SW; Reamtong O; Eyers C; Gaskell SJ; Stables JP; Liu R; Kohn H
J Med Chem; 2009 Nov; 52(21):6897-911. PubMed ID: 19795888
[TBL] [Abstract][Full Text] [Related]
2. Proteomic searches comparing two (R)-lacosamide affinity baits: An electrophilic arylisothiocyanate and a photoactivated arylazide group.
Park KD; Stables JP; Liu R; Kohn H
Org Biomol Chem; 2010 Jun; 8(12):2803-13. PubMed ID: 20405068
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
Salomé C; Salomé-Grosjean E; Park KD; Morieux P; Swendiman R; DeMarco E; Stables JP; Kohn H
J Med Chem; 2010 Feb; 53(3):1288-305. PubMed ID: 20041718
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives.
Morieux P; Stables JP; Kohn H
Bioorg Med Chem; 2008 Oct; 16(19):8968-75. PubMed ID: 18789868
[TBL] [Abstract][Full Text] [Related]
5. Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 ζ.
Park KD; Kim D; Reamtong O; Eyers C; Gaskell SJ; Liu R; Kohn H
J Am Chem Soc; 2011 Jul; 133(29):11320-30. PubMed ID: 21692503
[TBL] [Abstract][Full Text] [Related]
6. The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide.
Morieux P; Salomé C; Park KD; Stables JP; Kohn H
J Med Chem; 2010 Aug; 53(15):5716-26. PubMed ID: 20614888
[TBL] [Abstract][Full Text] [Related]
7. Lacosamide: a review of preclinical properties.
Beyreuther BK; Freitag J; Heers C; Krebsfänger N; Scharfenecker U; Stöhr T
CNS Drug Rev; 2007; 13(1):21-42. PubMed ID: 17461888
[TBL] [Abstract][Full Text] [Related]
8. Design and evaluation of affinity labels of functionalized amino acid anticonvulsants.
LeTiran A; Stables JP; Kohn H
J Med Chem; 2002 Oct; 45(21):4762-73. PubMed ID: 12361404
[TBL] [Abstract][Full Text] [Related]
9. Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides.
Baruah PK; Dinsmore J; King AM; Salomé C; De Ryck M; Kaminski R; Provins L; Kohn H
Bioorg Med Chem; 2012 Jun; 20(11):3551-64. PubMed ID: 22546207
[TBL] [Abstract][Full Text] [Related]
10. The anticonvulsant activities of functionalized N-benzyl 2-acetamidoacetamides. The importance of the 2-acetamido substituent.
Choi D; Stables JP; Kohn H
Bioorg Med Chem; 1996 Dec; 4(12):2105-14. PubMed ID: 9022975
[TBL] [Abstract][Full Text] [Related]
11. Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels.
Wang Y; Park KD; Salome C; Wilson SM; Stables JP; Liu R; Khanna R; Kohn H
ACS Chem Neurosci; 2011 Feb; 2(2):90-106. PubMed ID: 21532923
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and anticonvulsant activities of N-Benzyl-2-acetamidopropionamide derivatives.
Choi D; Stables JP; Kohn H
J Med Chem; 1996 Apr; 39(9):1907-16. PubMed ID: 8627614
[TBL] [Abstract][Full Text] [Related]
13. Discovery of lacosamide affinity bait agents that exhibit potent voltage-gated sodium channel blocking properties.
Park KD; Yang XF; Lee H; Dustrude ET; Wang Y; Khanna R; Kohn H
ACS Chem Neurosci; 2013 Mar; 4(3):463-74. PubMed ID: 23509982
[TBL] [Abstract][Full Text] [Related]
14. Drug binding assays do not reveal specific binding of lacosamide to collapsin response mediator protein 2 (CRMP-2).
Wolff C; Carrington B; Varrin-Doyer M; Vandendriessche A; Van der Perren C; Famelart M; Gillard M; Foerch P; Rogemond V; Honnorat J; Lawson A; Miller K
CNS Neurosci Ther; 2012 Jun; 18(6):493-500. PubMed ID: 22672303
[TBL] [Abstract][Full Text] [Related]
15. Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization.
Wilson SM; Xiong W; Wang Y; Ping X; Head JD; Brittain JM; Gagare PD; Ramachandran PV; Jin X; Khanna R
Neuroscience; 2012 May; 210():451-66. PubMed ID: 22433297
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and anticonvulsant activities of alpha-heterocyclic alpha-acetamido-N-benzylacetamide derivatives.
Kohn H; Sawhney KN; Bardel P; Robertson DW; Leander JD
J Med Chem; 1993 Oct; 36(22):3350-60. PubMed ID: 8230125
[TBL] [Abstract][Full Text] [Related]
17. The anti-epileptic drug lacosamide (Vimpat) has anxiolytic property in rodents.
Higgins GA; Breysse N; Undzys E; Kuo C; Joharchi N; Derksen DR; Xin T; Isaac M; Slassi M
Eur J Pharmacol; 2009 Dec; 624(1-3):1-9. PubMed ID: 19818346
[TBL] [Abstract][Full Text] [Related]
18. The anticonvulsant activities of N-benzyl 3-methoxypropionamides.
Andurkar SV; Stables JP; Kohn H
Bioorg Med Chem; 1999 Nov; 7(11):2381-9. PubMed ID: 10632047
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and anticonvulsant activity of some omega-(1H-imidazol-1-yl)-N-phenylacetamide and propionamide derivatives.
Soyer Z; Kiliç FS; Erol K; Pabuçcuoğlu V
Farmaco; 2004 Aug; 59(8):595-600. PubMed ID: 15262528
[TBL] [Abstract][Full Text] [Related]
20. Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain-attenuating properties.
King AM; Salomé C; Salomé-Grosjean E; De Ryck M; Kaminski R; Valade A; Stables JP; Kohn H
J Med Chem; 2011 Oct; 54(19):6417-31. PubMed ID: 21861463
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]