247 related articles for article (PubMed ID: 19797606)
1. Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid.
Owen BM; Milona A; van Mil S; Clements P; Holder J; Boudjelal M; Cairns W; Parker M; White R; Williamson C
Drug Metab Dispos; 2010 Jan; 38(1):143-9. PubMed ID: 19797606
[TBL] [Abstract][Full Text] [Related]
2. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity.
Zhang J; Huang W; Qatanani M; Evans RM; Moore DD
J Biol Chem; 2004 Nov; 279(47):49517-22. PubMed ID: 15358766
[TBL] [Abstract][Full Text] [Related]
3. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.
Xie W; Radominska-Pandya A; Shi Y; Simon CM; Nelson MC; Ong ES; Waxman DJ; Evans RM
Proc Natl Acad Sci U S A; 2001 Mar; 98(6):3375-80. PubMed ID: 11248086
[TBL] [Abstract][Full Text] [Related]
4. Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury.
Wang YG; Zhou JM; Ma ZC; Li H; Liang QD; Tan HL; Xiao CR; Zhang BL; Gao Y
Chem Biol Interact; 2012 Oct; 200(1):11-20. PubMed ID: 22982774
[TBL] [Abstract][Full Text] [Related]
5. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
Staudinger JL; Goodwin B; Jones SA; Hawkins-Brown D; MacKenzie KI; LaTour A; Liu Y; Klaassen CD; Brown KK; Reinhard J; Willson TM; Koller BH; Kliewer SA
Proc Natl Acad Sci U S A; 2001 Mar; 98(6):3369-74. PubMed ID: 11248085
[TBL] [Abstract][Full Text] [Related]
6. Lignans from Schisandra sphenanthera protect against lithocholic acid-induced cholestasis by pregnane X receptor activation in mice.
Fan S; Liu C; Jiang Y; Gao Y; Chen Y; Fu K; Yao X; Huang M; Bi H
J Ethnopharmacol; 2019 Dec; 245():112103. PubMed ID: 31336134
[TBL] [Abstract][Full Text] [Related]
7. Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).
Sonoda J; Xie W; Rosenfeld JM; Barwick JL; Guzelian PS; Evans RM
Proc Natl Acad Sci U S A; 2002 Oct; 99(21):13801-6. PubMed ID: 12370413
[TBL] [Abstract][Full Text] [Related]
8. Gastrectomy increases the expression of hepatic cytochrome P450 3A by increasing lithocholic acid-producing enteric bacteria in mice.
Ishii M; Toda T; Ikarashi N; Kusunoki Y; Kon R; Ochiai W; Machida Y; Sugiyama K
Biol Pharm Bull; 2014; 37(2):298-305. PubMed ID: 24270587
[TBL] [Abstract][Full Text] [Related]
9. Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.
Fisher CD; Jackson JP; Lickteig AJ; Augustine LM; Cherrington NJ
Arch Toxicol; 2008 Dec; 82(12):959-64. PubMed ID: 18488193
[TBL] [Abstract][Full Text] [Related]
10. In vivo induction of CYP in mice by carbamazepine is independent on PXR.
Liu A; Wang C; Hehir M; Zhou T; Yang J
Pharmacol Rep; 2015 Apr; 67(2):299-304. PubMed ID: 25712654
[TBL] [Abstract][Full Text] [Related]
11. Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis.
Teng S; Piquette-Miller M
Br J Pharmacol; 2007 Jun; 151(3):367-76. PubMed ID: 17435798
[TBL] [Abstract][Full Text] [Related]
12. In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice.
Scheer N; Ross J; Kapelyukh Y; Rode A; Wolf CR
Drug Metab Dispos; 2010 Jul; 38(7):1046-53. PubMed ID: 20354104
[TBL] [Abstract][Full Text] [Related]
13. Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.
Park YJ; Lee EK; Lee YK; Park DJ; Jang HC; Moore DD
Toxicol Appl Pharmacol; 2012 Sep; 263(2):131-7. PubMed ID: 22503787
[TBL] [Abstract][Full Text] [Related]
14. Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene.
Gnerre C; Blättler S; Kaufmann MR; Looser R; Meyer UA
Pharmacogenetics; 2004 Oct; 14(10):635-45. PubMed ID: 15454728
[TBL] [Abstract][Full Text] [Related]
15. Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity.
Kitada H; Miyata M; Nakamura T; Tozawa A; Honma W; Shimada M; Nagata K; Sinal CJ; Guo GL; Gonzalez FJ; Yamazoe Y
J Biol Chem; 2003 May; 278(20):17838-44. PubMed ID: 12637555
[TBL] [Abstract][Full Text] [Related]
16. A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.
Saini SP; Sonoda J; Xu L; Toma D; Uppal H; Mu Y; Ren S; Moore DD; Evans RM; Xie W
Mol Pharmacol; 2004 Feb; 65(2):292-300. PubMed ID: 14742670
[TBL] [Abstract][Full Text] [Related]
17. Expression of CYP3A in chronic ethanol-fed mice is mediated by endogenous pregnane X receptor ligands formed by enhanced cholesterol metabolism.
Je YT; Sim WC; Kim DG; Jung BH; Shin HS; Lee BH
Arch Toxicol; 2015 Apr; 89(4):579-89. PubMed ID: 24853400
[TBL] [Abstract][Full Text] [Related]
18. Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice.
Cheng J; Fang ZZ; Kim JH; Krausz KW; Tanaka N; Chiang JY; Gonzalez FJ
J Lipid Res; 2014 Mar; 55(3):455-65. PubMed ID: 24343899
[TBL] [Abstract][Full Text] [Related]
19. Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.
Honda A; Miyazaki T; Iwamoto J; Hirayama T; Morishita Y; Monma T; Ueda H; Mizuno S; Sugiyama F; Takahashi S; Ikegami T
J Lipid Res; 2020 Jan; 61(1):54-69. PubMed ID: 31645370
[TBL] [Abstract][Full Text] [Related]
20. Tanshinone IIA exerts protective effects in a LCA-induced cholestatic liver model associated with participation of pregnane X receptor.
Zhang X; Ma Z; Liang Q; Tang X; Hu D; Liu C; Tan H; Xiao C; Zhang B; Wang Y; Gao Y
J Ethnopharmacol; 2015 Apr; 164():357-67. PubMed ID: 25660334
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
