These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

103 related articles for article (PubMed ID: 19800786)

  • 1. Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability.
    Josien H; Bara T; Rajagopalan M; Clader JW; Greenlee WJ; Favreau L; Hyde LA; Nomeir AA; Parker EM; Song L; Zhang L; Zhang Q
    Bioorg Med Chem Lett; 2009 Nov; 19(21):6032-7. PubMed ID: 19800786
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors.
    Josien H; Bara T; Rajagopalan M; Asberom T; Clader JW; Favreau L; Greenlee WJ; Hyde LA; Nomeir AA; Parker EM; Pissarnitski DA; Song L; Wong GT; Zhang L; Zhang Q; Zhao Z
    Bioorg Med Chem Lett; 2007 Oct; 17(19):5330-5. PubMed ID: 17761417
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors.
    Zhao Z; Pissarnitski DA; Josien HB; Bara TA; Clader JW; Li H; McBriar MD; Rajagopalan M; Xu R; Terracina G; Hyde L; Song L; Zhang L; Parker EM; Osterman R; Buevich AV
    Eur J Med Chem; 2016 Nov; 124():36-48. PubMed ID: 27560281
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors.
    Li H; Asberom T; Bara TA; Clader JW; Greenlee WJ; Josien HB; McBriar MD; Nomeir A; Pissarnitski DA; Rajagopalan M; Xu R; Zhao Z; Song L; Zhang L
    Bioorg Med Chem Lett; 2007 Nov; 17(22):6290-4. PubMed ID: 17890085
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis, and structure-activity relationship studies of N-arylsulfonyl morpholines as γ-secretase inhibitors.
    Li H; Xu R; Cole D; Clader JW; Greenlee WJ; Nomeir AA; Song L; Zhang L
    Bioorg Med Chem Lett; 2010 Nov; 20(22):6606-9. PubMed ID: 20933414
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.
    McBriar MD; Clader JW; Chu I; Del Vecchio RA; Favreau L; Greenlee WJ; Hyde LA; Nomeir AA; Parker EM; Pissarnitski DA; Song L; Zhang L; Zhao Z
    Bioorg Med Chem Lett; 2008 Jan; 18(1):215-9. PubMed ID: 17988864
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
    Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
    Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
    Mayer SC; Kreft AF; Harrison B; Abou-Gharbia M; Antane M; Aschmies S; Atchison K; Chlenov M; Cole DC; Comery T; Diamantidis G; Ellingboe J; Fan K; Galante R; Gonzales C; Ho DM; Hoke ME; Hu Y; Huryn D; Jain U; Jin M; Kremer K; Kubrak D; Lin M; Lu P; Magolda R; Martone R; Moore W; Oganesian A; Pangalos MN; Porte A; Reinhart P; Resnick L; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Wang T; Woller K; Xu Z; Zaleska MM; Zeldis J; Zhang M; Zhou H; Jacobsen JS
    J Med Chem; 2008 Dec; 51(23):7348-51. PubMed ID: 19012391
    [TBL] [Abstract][Full Text] [Related]  

  • 10. N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors.
    Parker MF; Barten DM; Bergstrom CP; Bronson JJ; Corsa JA; Deshpande MS; Felsenstein KM; Guss VL; Hansel SB; Johnson G; Keavy DJ; Lau WY; Mock J; Prasad CV; Polson CT; Sloan CP; Smith DW; Wallace OB; Wang HH; Williams A; Zheng M
    Bioorg Med Chem Lett; 2007 Aug; 17(16):4432-6. PubMed ID: 17606371
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease.
    Asberom T; Zhao Z; Bara TA; Clader JW; Greenlee WJ; Hyde LA; Josien HB; Li W; McPhail AT; Nomeir AA; Parker EM; Rajagopalan M; Song L; Wong GT; Zhang L; Zhang Q; Pissarnitski DA
    Bioorg Med Chem Lett; 2007 Jan; 17(2):511-6. PubMed ID: 17079141
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors.
    Zhao Z; Pissarnitski DA; Josien HB; Wu WL; Xu R; Li H; Clader JW; Burnett DA; Terracina G; Hyde L; Lee J; Song L; Zhang L; Parker EM
    J Med Chem; 2015 Nov; 58(22):8806-17. PubMed ID: 26496070
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
    Aubele DL; Truong AP; Dressen DB; Probst GD; Bowers S; Mattson MN; Semko CM; Sun M; Garofalo AW; Konradi AW; Sham HL; Zmolek W; Wong K; Goldbach E; Quinn KP; Sauer JM; Brigham EF; Wallace W; Nguyen L; Bova MP; Hemphill SS; Basi G
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5791-4. PubMed ID: 21885276
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors.
    Guo T; Gu H; Hobbs DW; Rokosz LL; Stauffer TM; Jacob B; Clader JW
    Bioorg Med Chem Lett; 2007 Jun; 17(11):3010-3. PubMed ID: 17418571
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Recent progress in the medicinal chemistry of gamma-secretase inhibitors.
    Olson RE; Albright CF
    Curr Top Med Chem; 2008; 8(1):17-33. PubMed ID: 18220929
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.
    Sasikumar TK; Qiang L; Burnett DA; Cole D; Xu R; Li H; Greenlee WJ; Clader J; Zhang L; Hyde L
    Bioorg Med Chem Lett; 2010 Jun; 20(12):3632-5. PubMed ID: 20493690
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse.
    Hyde LA; McHugh NA; Chen J; Zhang Q; Manfra D; Nomeir AA; Josien H; Bara T; Clader JW; Zhang L; Parker EM; Higgins GA
    J Pharmacol Exp Ther; 2006 Dec; 319(3):1133-43. PubMed ID: 16946102
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.
    Stepan AF; Karki K; McDonald WS; Dorff PH; Dutra JK; Dirico KJ; Won A; Subramanyam C; Efremov IV; O'Donnell CJ; Nolan CE; Becker SL; Pustilnik LR; Sneed B; Sun H; Lu Y; Robshaw AE; Riddell D; O'Sullivan TJ; Sibley E; Capetta S; Atchison K; Hallgren AJ; Miller E; Wood A; Obach RS
    J Med Chem; 2011 Nov; 54(22):7772-83. PubMed ID: 21995460
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE).
    Boy KM; Guernon JM; Shi J; Toyn JH; Meredith JE; Barten DM; Burton CR; Albright CF; Marcinkeviciene J; Good AC; Tebben AJ; Muckelbauer JK; Camac DM; Lentz KA; Bronson JJ; Olson RE; Macor JE; Thompson LA
    Bioorg Med Chem Lett; 2011 Nov; 21(22):6916-24. PubMed ID: 21782431
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors.
    Zhu H; Young MB; Nantermet PG; Graham SL; Colussi D; Lai MT; Pietrak B; Price EA; Sankaranarayanan S; Shi XP; Tugusheva K; Holahan MA; Michener MS; Cook JJ; Simon A; Hazuda DJ; Vacca JP; Rajapakse HA
    Bioorg Med Chem Lett; 2010 Mar; 20(5):1779-82. PubMed ID: 20122828
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.