BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

323 related articles for article (PubMed ID: 19804379)

  • 1. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
    Jäger S; Leuchtenberger S; Martin A; Czirr E; Wesselowski J; Dieckmann M; Waldron E; Korth C; Koo EH; Heneka M; Weggen S; Pietrzik CU
    J Neurochem; 2009 Dec; 111(6):1369-82. PubMed ID: 19804379
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Trafficking of amyloid β-precursor protein products C83 and C99 on the endocytic pathway.
    Hare J
    Biochem Biophys Res Commun; 2010 Oct; 401(2):219-24. PubMed ID: 20849818
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms.
    Cater MA; McInnes KT; Li QX; Volitakis I; La Fontaine S; Mercer JF; Bush AI
    Biochem J; 2008 May; 412(1):141-52. PubMed ID: 18248325
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
    Peng Y; Jiang L; Lee DY; Schachter SC; Ma Z; Lemere CA
    J Neurosci Res; 2006 Sep; 84(4):903-11. PubMed ID: 16862548
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.
    Abramowski D; Wiederhold KH; Furrer U; Jaton AL; Neuenschwander A; Runser MJ; Danner S; Reichwald J; Ammaturo D; Staab D; Stoeckli M; Rueeger H; Neumann U; Staufenbiel M
    J Pharmacol Exp Ther; 2008 Nov; 327(2):411-24. PubMed ID: 18687920
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein.
    Nunan J; Williamson NA; Hill AF; Sernee MF; Masters CL; Small DH
    J Neurosci Res; 2003 Nov; 74(3):378-85. PubMed ID: 14598314
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
    J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.
    Kokawa A; Ishihara S; Fujiwara H; Nobuhara M; Iwata M; Ihara Y; Funamoto S
    Acta Neuropathol Commun; 2015 Nov; 3():66. PubMed ID: 26531305
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.
    Fu H; Dou J; Li W; Cui W; Mak S; Hu Q; Luo J; Lam CS; Pang Y; Youdim MB; Han Y
    Eur J Pharmacol; 2009 Nov; 623(1-3):14-21. PubMed ID: 19765582
    [TBL] [Abstract][Full Text] [Related]  

  • 10. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
    Nishitomi K; Sakaguchi G; Horikoshi Y; Gray AJ; Maeda M; Hirata-Fukae C; Becker AG; Hosono M; Sakaguchi I; Minami SS; Nakajima Y; Li HF; Takeyama C; Kihara T; Ota A; Wong PC; Aisen PS; Kato A; Kinoshita N; Matsuoka Y
    J Neurochem; 2006 Dec; 99(6):1555-63. PubMed ID: 17083447
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S; Price EA; Wu G; Crouthamel MC; Shi XP; Tugusheva K; Tyler KX; Kahana J; Ellis J; Jin L; Steele T; Stachel S; Coburn C; Simon AJ
    J Pharmacol Exp Ther; 2008 Mar; 324(3):957-69. PubMed ID: 18156464
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.
    Sheng B; Gong K; Niu Y; Liu L; Yan Y; Lu G; Zhang L; Hu M; Zhao N; Zhang X; Tang P; Gong Y
    Free Radic Biol Med; 2009 May; 46(10):1362-75. PubMed ID: 19264123
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L; Gan L; Yu GQ; Essrich C; Mucke L
    J Neurochem; 2004 Dec; 91(6):1260-74. PubMed ID: 15584903
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Abeta(1-40)-induced secretion of matrix metalloproteinase-9 results in sAPPalpha release by association with cell surface APP.
    Talamagas AA; Efthimiopoulos S; Tsilibary EC; Figueiredo-Pereira ME; Tzinia AK
    Neurobiol Dis; 2007 Dec; 28(3):304-15. PubMed ID: 17761425
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage.
    Kume H; Maruyama K; Kametani F
    Int J Mol Med; 2004 Jan; 13(1):121-5. PubMed ID: 14654982
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
    Sinha S; Anderson JP; Barbour R; Basi GS; Caccavello R; Davis D; Doan M; Dovey HF; Frigon N; Hong J; Jacobson-Croak K; Jewett N; Keim P; Knops J; Lieberburg I; Power M; Tan H; Tatsuno G; Tung J; Schenk D; Seubert P; Suomensaari SM; Wang S; Walker D; Zhao J; McConlogue L; John V
    Nature; 1999 Dec; 402(6761):537-40. PubMed ID: 10591214
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.
    Rabe S; Reichwald J; Ammaturo D; de Strooper B; Saftig P; Neumann U; Staufenbiel M
    J Neurochem; 2011 Oct; 119(1):231-9. PubMed ID: 21812781
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
    Yan R; Bienkowski MJ; Shuck ME; Miao H; Tory MC; Pauley AM; Brashier JR; Stratman NC; Mathews WR; Buhl AE; Carter DB; Tomasselli AG; Parodi LA; Heinrikson RL; Gurney ME
    Nature; 1999 Dec; 402(6761):533-7. PubMed ID: 10591213
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Gamma-secretase activity is present in rafts but is not cholesterol-dependent.
    Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; Ohno-Iwashita Y; Ihara Y
    Biochemistry; 2003 Dec; 42(47):13977-86. PubMed ID: 14636066
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.