BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

238 related articles for article (PubMed ID: 19805107)

  • 1. Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma.
    Ayrault O; Godeny MD; Dillon C; Zindy F; Fitzgerald P; Roussel MF; Beere HM
    Proc Natl Acad Sci U S A; 2009 Oct; 106(40):17037-42. PubMed ID: 19805107
    [TBL] [Abstract][Full Text] [Related]  

  • 2. HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair.
    Koll TT; Feis SS; Wright MH; Teniola MM; Richardson MM; Robles AI; Bradsher J; Capala J; Varticovski L
    Mol Cancer Ther; 2008 Jul; 7(7):1985-92. PubMed ID: 18645008
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.
    Maclean KH; Dorsey FC; Cleveland JL; Kastan MB
    J Clin Invest; 2008 Jan; 118(1):79-88. PubMed ID: 18097482
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The apoptotic effect and associated signalling of HSP90 inhibitor 17-DMAG in hepatocellular carcinoma cells.
    Leng AM; Liu T; Yang J; Cui JF; Li XH; Zhu YN; Xiong T; Zhang G; Chen Y
    Cell Biol Int; 2012 Oct; 36(10):893-9. PubMed ID: 22694478
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines.
    Robles AI; Wright MH; Gandhi B; Feis SS; Hanigan CL; Wiestner A; Varticovski L
    Clin Cancer Res; 2006 Nov; 12(21):6547-56. PubMed ID: 17085670
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
    He K; Zheng X; Zhang L; Yu J
    Mol Cancer Ther; 2013 Nov; 12(11):2559-68. PubMed ID: 23966620
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells.
    Lin K; Rockliffe N; Johnson GG; Sherrington PD; Pettitt AR
    Oncogene; 2008 Apr; 27(17):2445-55. PubMed ID: 17982489
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation.
    Fukumoto R; Kiang JG
    Radiat Res; 2011 Sep; 176(3):333-45. PubMed ID: 21663398
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.
    Schwock J; Pham NA; Cao MP; Hedley DW
    Cancer Chemother Pharmacol; 2008 Apr; 61(4):669-81. PubMed ID: 17579866
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 17-DMAG induces heat shock protein 90 functional impairment in human bladder cancer cells: knocking down the hallmark traits of malignancy.
    Karkoulis PK; Stravopodis DJ; Voutsinas GE
    Tumour Biol; 2016 May; 37(5):6861-73. PubMed ID: 26662567
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human mantle cell lymphoma (MCL) cells.
    Rao R; Lee P; Fiskus W; Yang Y; Joshi R; Wang Y; Buckley K; Balusu R; Chen J; Koul S; Joshi A; Upadhyay S; Tao J; Sotomayor E; Bhalla KN
    Cancer Biol Ther; 2009 Jul; 8(13):1273-80. PubMed ID: 19440035
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.
    Georgakis GV; Li Y; Rassidakis GZ; Martinez-Valdez H; Medeiros LJ; Younes A
    Clin Cancer Res; 2006 Jan; 12(2):584-90. PubMed ID: 16428504
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.
    Uziel T; Zindy F; Xie S; Lee Y; Forget A; Magdaleno S; Rehg JE; Calabrese C; Solecki D; Eberhart CG; Sherr SE; Plimmer S; Clifford SC; Hatten ME; McKinnon PJ; Gilbertson RJ; Curran T; Sherr CJ; Roussel MF
    Genes Dev; 2005 Nov; 19(22):2656-67. PubMed ID: 16260494
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors.
    Vaseva AV; Yallowitz AR; Marchenko ND; Xu S; Moll UM
    Cell Death Dis; 2011 May; 2(5):e156. PubMed ID: 21562588
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cooperative enhancement of radiosensitivity after combined treatment of 17-(allylamino)-17-demethoxygeldanamycin and celecoxib in human lung and colon cancer cell lines.
    Kim YM; Pyo H
    DNA Cell Biol; 2012 Jan; 31(1):15-29. PubMed ID: 21830942
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hypoxia attenuates Hsp90 inhibitor 17-DMAG-induced cyclin B1 accumulation in hepatocellular carcinoma cells.
    Zhang J; Li H; Huang Z; He Y; Zhou X; Huang T; Dai P; Duan D; Ma X; Yin Q; Wang X; Liu H; Chen S; Zou F; Chen X
    Cell Stress Chaperones; 2016 Mar; 21(2):339-48. PubMed ID: 26786409
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition.
    Hertlein E; Wagner AJ; Jones J; Lin TS; Maddocks KJ; Towns WH; Goettl VM; Zhang X; Jarjoura D; Raymond CA; West DA; Croce CM; Byrd JC; Johnson AJ
    Blood; 2010 Jul; 116(1):45-53. PubMed ID: 20351313
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis.
    Tomcik M; Zerr P; Pitkowski J; Palumbo-Zerr K; Avouac J; Distler O; Becvar R; Senolt L; Schett G; Distler JH
    Ann Rheum Dis; 2014 Jun; 73(6):1215-22. PubMed ID: 23661493
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
    Shreeram S; Hee WK; Demidov ON; Kek C; Yamaguchi H; Fornace AJ; Anderson CW; Appella E; Bulavin DV
    J Exp Med; 2006 Dec; 203(13):2793-9. PubMed ID: 17158963
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice.
    Ambade A; Catalano D; Lim A; Mandrekar P
    Hepatology; 2012 May; 55(5):1585-95. PubMed ID: 22105779
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.