216 related articles for article (PubMed ID: 19807124)
1. Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds.
Emert-Sedlak L; Kodama T; Lerner EC; Dai W; Foster C; Day BW; Lazo JS; Smithgall TE
ACS Chem Biol; 2009 Nov; 4(11):939-47. PubMed ID: 19807124
[TBL] [Abstract][Full Text] [Related]
2. Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.
Emert-Sedlak LA; Narute P; Shu ST; Poe JA; Shi H; Yanamala N; Alvarado JJ; Lazo JS; Yeh JI; Johnston PA; Smithgall TE
Chem Biol; 2013 Jan; 20(1):82-91. PubMed ID: 23352142
[TBL] [Abstract][Full Text] [Related]
3. Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.
Narute PS; Smithgall TE
PLoS One; 2012; 7(2):e32561. PubMed ID: 22393415
[TBL] [Abstract][Full Text] [Related]
4. Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor.
Wales TE; Hochrein JM; Morgan CR; Emert-Sedlak LA; Smithgall TE; Engen JR
Biochemistry; 2015 Oct; 54(41):6382-91. PubMed ID: 26440750
[TBL] [Abstract][Full Text] [Related]
5. Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen.
Trible RP; Narute P; Emert-Sedlak LA; Alvarado JJ; Atkins K; Thomas L; Kodama T; Yanamala N; Korotchenko V; Day BW; Thomas G; Smithgall TE
Retrovirology; 2013 Nov; 10():135. PubMed ID: 24229420
[TBL] [Abstract][Full Text] [Related]
6. The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement.
Chutiwitoonchai N; Hiyoshi M; Mwimanzi P; Ueno T; Adachi A; Ode H; Sato H; Fackler OT; Okada S; Suzu S
PLoS One; 2011; 6(11):e27696. PubMed ID: 22110726
[TBL] [Abstract][Full Text] [Related]
7. Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.
Alvarado JJ; Tarafdar S; Yeh JI; Smithgall TE
J Biol Chem; 2014 Oct; 289(41):28539-53. PubMed ID: 25122770
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and structure-activity analysis of diphenylpyrazolodiazene inhibitors of the HIV-1 Nef virulence factor.
Iyer PC; Zhao J; Emert-Sedlak LA; Moore KK; Smithgall TE; Day BW
Bioorg Med Chem Lett; 2014 Apr; 24(7):1702-6. PubMed ID: 24650642
[TBL] [Abstract][Full Text] [Related]
9. HIV-1 Nef-Induced Secretion of the Proinflammatory Protease TACE into Extracellular Vesicles Is Mediated by Raf-1 and Can Be Suppressed by Clinical Protein Kinase Inhibitors.
Zhao Z; Fagerlund R; Baur AS; Saksela K
J Virol; 2021 Apr; 95(9):. PubMed ID: 33597213
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists.
Emert-Sedlak LA; Loughran HM; Shi H; Kulp JL; Shu ST; Zhao J; Day BW; Wrobel JE; Reitz AB; Smithgall TE
Bioorg Med Chem Lett; 2016 Mar; 26(5):1480-1484. PubMed ID: 26852364
[TBL] [Abstract][Full Text] [Related]
11. HIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: a Nef-dependent phenomenon.
Cornall A; Mak J; Greenway A; Tachedjian G
Viruses; 2013 Sep; 5(9):2235-52. PubMed ID: 24051604
[TBL] [Abstract][Full Text] [Related]
12. Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes.
Staudt RP; Alvarado JJ; Emert-Sedlak LA; Shi H; Shu ST; Wales TE; Engen JR; Smithgall TE
J Biol Chem; 2020 Oct; 295(44):15158-15171. PubMed ID: 32862141
[TBL] [Abstract][Full Text] [Related]
13. Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase.
Choi HJ; Smithgall TE
J Mol Biol; 2004 Nov; 343(5):1255-68. PubMed ID: 15491611
[TBL] [Abstract][Full Text] [Related]
14. A mammalian two-hybrid screening system for inhibitors of interaction between HIV Nef and the cellular tyrosine kinase Hck.
Murakami Y; Fukazawa H; Kobatake T; Yamagoe S; Takebe Y; Tobiume M; Matsuda M; Uehara Y
Antiviral Res; 2002 Jul; 55(1):161-8. PubMed ID: 12076760
[TBL] [Abstract][Full Text] [Related]
15. Oligomerization is required for HIV-1 Nef-induced activation of the Src family protein-tyrosine kinase, Hck.
Ye H; Choi HJ; Poe J; Smithgall TE
Biochemistry; 2004 Dec; 43(50):15775-84. PubMed ID: 15595833
[TBL] [Abstract][Full Text] [Related]
16. HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication.
Poe JA; Smithgall TE
J Mol Biol; 2009 Nov; 394(2):329-42. PubMed ID: 19781555
[TBL] [Abstract][Full Text] [Related]
17. Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms.
Hassan R; Suzu S; Hiyoshi M; Takahashi-Makise N; Ueno T; Agatsuma T; Akari H; Komano J; Takebe Y; Motoyoshi K; Okada S
J Cell Physiol; 2009 Nov; 221(2):458-68. PubMed ID: 19585521
[TBL] [Abstract][Full Text] [Related]
18. Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck.
Olszewski A; Sato K; Aron ZD; Cohen F; Harris A; McDougall BR; Robinson WE; Overman LE; Weiss GA
Proc Natl Acad Sci U S A; 2004 Sep; 101(39):14079-84. PubMed ID: 15371598
[TBL] [Abstract][Full Text] [Related]
19. Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo.
Briggs SD; Lerner EC; Smithgall TE
Biochemistry; 2000 Jan; 39(3):489-95. PubMed ID: 10642173
[TBL] [Abstract][Full Text] [Related]
20. The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism.
Dutartre H; Harris M; Olive D; Collette Y
Virology; 1998 Aug; 247(2):200-11. PubMed ID: 9705913
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
