These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

381 related articles for article (PubMed ID: 19812352)

  • 1. Identification of multiple glutathione conjugates of 8-amino- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (nomifensine) in liver microsomes and hepatocyte preparations: evidence of the bioactivation of nomifensine.
    Yu J; Mathisen DE; Burdette D; Brown DG; Becker C; Aharony D
    Drug Metab Dispos; 2010 Jan; 38(1):46-60. PubMed ID: 19812352
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In vitro metabolism studies of nomifensine monooxygenation pathways: metabolite identification, reaction phenotyping, and bioactivation mechanism.
    Yu J; Brown DG; Burdette D
    Drug Metab Dispos; 2010 Oct; 38(10):1767-78. PubMed ID: 20595377
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.
    Erve JC; Vashishtha SC; DeMaio W; Talaat RE
    Drug Metab Dispos; 2007 Jun; 35(6):908-16. PubMed ID: 17353349
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
    Yan Z; Easterwood LM; Maher N; Torres R; Huebert N; Yost GS
    Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of primary and sequential bioactivation pathways of carbamazepine in human liver microsomes using liquid chromatography/tandem mass spectrometry.
    Bu HZ; Zhao P; Dalvie DK; Pool WF
    Rapid Commun Mass Spectrom; 2007; 21(20):3317-22. PubMed ID: 17879390
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bioactivation of 2,3-diaminopyridine-containing bradykinin B1 receptor antagonists: irreversible binding to liver microsomal proteins and formation of glutathione conjugates.
    Tang C; Subramanian R; Kuo Y; Krymgold S; Lu P; Kuduk SD; Ng C; Feng DM; Elmore C; Soli E; Ho J; Bock MG; Baillie TA; Prueksaritanont T
    Chem Res Toxicol; 2005 Jun; 18(6):934-45. PubMed ID: 15962928
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Bioactivation of glafenine by human liver microsomes and peroxidases: identification of electrophilic iminoquinone species and GSH conjugates.
    Wen B; Moore DJ
    Drug Metab Dispos; 2011 Sep; 39(9):1511-21. PubMed ID: 21628497
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of novel glutathione conjugates of terbinafine in liver microsomes and hepatocytes across species.
    Patil A; Ladumor MK; Kamble SH; Johnson BM; Subramanian M; Sinz MW; Singh DK; Putlur S; Bhutani P; Ahire DS; Singh S
    Xenobiotica; 2019 Dec; 49(12):1403-1413. PubMed ID: 30747549
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
    Chen Q; Doss GA; Tung EC; Liu W; Tang YS; Braun MP; Didolkar V; Strauss JR; Wang RW; Stearns RA; Evans DC; Baillie TA; Tang W
    Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of the metabolites of rosmarinic acid in human liver microsomes using liquid chromatography combined with electrospray ionization tandem mass spectrometry.
    Su J; Jia F; Lu J; Chen W; Sun H; Liu T; Wu X
    Biomed Chromatogr; 2020 Apr; 34(4):e4806. PubMed ID: 32012312
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique.
    Ruan Q; Zhu M
    Chem Res Toxicol; 2010 May; 23(5):909-17. PubMed ID: 20297803
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
    Zhuo X; Zhao W; Zheng J; Humphreys WG; Shu YZ; Zhu M
    Chem Biol Interact; 2009 Oct; 181(2):227-35. PubMed ID: 19576871
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Bioactivation of sitaxentan in liver microsomes, hepatocytes, and expressed human P450s with characterization of the glutathione conjugate by liquid chromatography tandem mass spectrometry.
    Erve JC; Gauby S; Maynard JW; Svensson MA; Tonn G; Quinn KP
    Chem Res Toxicol; 2013 Jun; 26(6):926-36. PubMed ID: 23721565
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Comparative metabolism of 1,2,3,3,3-pentafluoropropene in male and female mouse, rat, dog, and human liver microsomes and cytosol and male rat hepatocytes via oxidative dehalogenation and glutathione S-conjugation pathways.
    Han X; Szostek B; Yang CH; Cheatham SF; Mingoia RT; Nabb DL; Gannon SA; Himmelstein MW; Jepson GW
    Drug Metab Dispos; 2011 Jul; 39(7):1288-93. PubMed ID: 21493824
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Thiazolidinedione bioactivation: a comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry.
    Alvarez-Sanchez R; Montavon F; Hartung T; Pähler A
    Chem Res Toxicol; 2006 Aug; 19(8):1106-16. PubMed ID: 16918252
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes.
    Lassila T; Rousu T; Mattila S; Chesné C; Pelkonen O; Turpeinen M; Tolonen A
    J Pharm Biomed Anal; 2015 Nov; 115():345-51. PubMed ID: 26263063
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: characterization of thioether conjugates by liquid chromatography/mass spectrometry and high field nuclear magnetic resonance spectroscopy.
    Chen H; Grover S; Yu L; Walker G; Mutlib A
    Chem Res Toxicol; 2010 Jan; 23(1):159-70. PubMed ID: 19961160
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In vitro metabolism of N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)thiourea: species comparison and identification of a novel thiocarbamide-glutathione adduct.
    Stevens GJ; Hitchcock K; Wang YK; Coppola GM; Versace RW; Chin JA; Shapiro M; Suwanrumpha S; Mangold BL
    Chem Res Toxicol; 1997 Jul; 10(7):733-41. PubMed ID: 9250406
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Bioactivation of flutamide metabolites by human liver microsomes.
    Kang P; Dalvie D; Smith E; Zhou S; Deese A; Nieman JA
    Drug Metab Dispos; 2008 Jul; 36(7):1425-37. PubMed ID: 18411402
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.