BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

153 related articles for article (PubMed ID: 19815418)

  • 1. Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: synthesis, cytotoxicity, DNA-binding and cell cycle evaluation.
    Xie L; Xiao Y; Wang F; Xu Y; Qian X; Zhang R; Cui J; Liu J
    Bioorg Med Chem; 2009 Nov; 17(21):7615-21. PubMed ID: 19815418
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis, and antitumor evaluation of novel acenaphtho[1,2-b]pyrrole-carboxylic acid esters with amino chain substitution.
    Liu F; Qian X; Cui J; Xiao Y; Zhang R; Li G
    Bioorg Med Chem; 2006 Jul; 14(13):4639-44. PubMed ID: 16516477
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: various DNA binding geometry and interesting antitumor capacity.
    Zhang Z; Yang Y; Zhang D; Wang Y; Qian X; Liu F
    Bioorg Med Chem; 2006 Oct; 14(20):6962-70. PubMed ID: 16828559
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents.
    Zhang Z; Jin L; Qian X; Wei M; Wang Y; Wang J; Yang Y; Xu Q; Xu Y; Liu F
    Chembiochem; 2007 Jan; 8(1):113-21. PubMed ID: 17139689
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Acenaphtho[1,2-b]pyrrole-based selective fibroblast growth factor receptors 1 (FGFR1) inhibitors: design, synthesis, and biological activity.
    Chen Z; Wang X; Zhu W; Cao X; Tong L; Li H; Xie H; Xu Y; Tan S; Kuang D; Ding J; Qian X
    J Med Chem; 2011 Jun; 54(11):3732-45. PubMed ID: 21517068
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1.
    Song T; Li X; Chang X; Liang X; Zhao Y; Wu G; Xie S; Su P; Wu Z; Feng Y; Zhang Z
    Bioorg Med Chem; 2013 Jan; 21(1):11-20. PubMed ID: 23206987
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): structure-based design and structure-activity relationship studies.
    Zhang Z; Wu G; Xie F; Song T; Chang X
    J Med Chem; 2011 Feb; 54(4):1101-5. PubMed ID: 21235240
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
    Mai A; Massa S; Cerbara I; Valente S; Ragno R; Bottoni P; Scatena R; Loidl P; Brosch G
    J Med Chem; 2004 Feb; 47(5):1098-109. PubMed ID: 14971890
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and biological evaluation of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukemic agents.
    Gowda NR; Kavitha CV; Chiruvella KK; Joy O; Rangappa KS; Raghavan SC
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4594-600. PubMed ID: 19616939
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Study on the interaction between 4-(2-diethylamino-ethylamino)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile and DNA by molecular spectra.
    Zhang Z; Yang Y; Liu F; Qian X; Xu Q
    Int J Biol Macromol; 2006 Feb; 38(1):59-64. PubMed ID: 16448691
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugates as anticancer agents.
    Wang JJ; Shen YK; Hu WP; Hsieh MC; Lin FL; Hsu MK; Hsu MH
    J Med Chem; 2006 Feb; 49(4):1442-9. PubMed ID: 16480280
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents.
    Rochais C; Lisowski V; Dallemagne P; Rault S
    Bioorg Med Chem; 2006 Dec; 14(24):8162-75. PubMed ID: 17011196
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis.
    Queiroz MJ; Calhelha RC; Vale-Silva LA; Pinto E; Almeida GM; Vasconcelos MH
    Eur J Med Chem; 2011 Jan; 46(1):236-40. PubMed ID: 21138784
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions.
    Kemnitzer W; Drewe J; Jiang S; Zhang H; Crogan-Grundy C; Labreque D; Bubenick M; Attardo G; Denis R; Lamothe S; Gourdeau H; Tseng B; Kasibhatla S; Cai SX
    J Med Chem; 2008 Feb; 51(3):417-23. PubMed ID: 18197614
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrrolo oximes.
    Shanab K; Pongprom N; Wulz E; Holzer W; Spreitzer H; Schmidt P; Aicher B; Müller G; Günther E
    Bioorg Med Chem Lett; 2007 Nov; 17(22):6091-5. PubMed ID: 17904839
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.
    Wells G; Martin CR; Howard PW; Sands ZA; Laughton CA; Tiberghien A; Woo CK; Masterson LA; Stephenson MJ; Hartley JA; Jenkins TC; Shnyder SD; Loadman PM; Waring MJ; Thurston DE
    J Med Chem; 2006 Sep; 49(18):5442-61. PubMed ID: 16942018
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel amidino-substituted thienyl- and furylvinylbenzimidazole: derivatives and their photochemical conversion into corresponding diazacyclopenta[c]fluorenes. synthesis, interactions with DNA and RNA, and antitumor evaluation. 4.
    Hranjec M; Piantanida I; Kralj M; Suman L; Pavelić K; Karminski-Zamola G
    J Med Chem; 2008 Aug; 51(16):4899-910. PubMed ID: 18652444
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and in vitro and in vivo antitumor activity of 2-phenylpyrroloquinolin-4-ones.
    Ferlin MG; Chiarelotto G; Gasparotto V; Dalla Via L; Pezzi V; Barzon L; Palù G; Castagliuolo I
    J Med Chem; 2005 May; 48(9):3417-27. PubMed ID: 15857148
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates.
    Kamal A; Ramu R; Tekumalla V; Khanna GB; Barkume MS; Juvekar AS; Zingde SM
    Bioorg Med Chem; 2007 Nov; 15(22):6868-75. PubMed ID: 17822905
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cytotoxic alpha-halogenoacrylic derivatives of distamycin A and congeners.
    Beria I; Baraldi PG; Cozzi P; Caldarelli M; Geroni C; Marchini S; Mongelli N; Romagnoli R
    J Med Chem; 2004 May; 47(10):2611-23. PubMed ID: 15115402
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.