These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

125 related articles for article (PubMed ID: 19821461)

  • 21. Tricyclic azepine derivatives: pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors.
    Smith L; Piatnitski EL; Kiselyov AS; Ouyang X; Chen X; Burdzovic-Wizemann S; Xu Y; Pan W; Chen X; Wang Y; Rosler RL; Patel SN; Chiang HH; Milligan DL; Columbus J; Wong WC; Doody JF; Hadari YR
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1643-6. PubMed ID: 16412636
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.
    Simard JR; Getlik M; Grütter C; Pawar V; Wulfert S; Rabiller M; Rauh D
    J Am Chem Soc; 2009 Sep; 131(37):13286-96. PubMed ID: 19572644
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Synthesis of a novel polyhydroxylated salicylic acid lactone framework.
    Rountree JS; Murphy PV
    Org Lett; 2009 Feb; 11(4):871-4. PubMed ID: 19170571
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Trends in kinase selectivity: insights for target class-focused library screening.
    Posy SL; Hermsmeier MA; Vaccaro W; Ott KH; Todderud G; Lippy JS; Trainor GL; Loughney DA; Johnson SR
    J Med Chem; 2011 Jan; 54(1):54-66. PubMed ID: 21128601
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Synthesis of purin-2-yl and purin-6-yl-aminoglucitols as C-nucleosidic ATP mimics and biological evaluation as FGFR3 inhibitors.
    Tak-Tak L; Barbault F; Maurel F; Busca P; Le Merrer Y
    Eur J Med Chem; 2011 Apr; 46(4):1254-62. PubMed ID: 21334122
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Identification of polyoxometalates as nanomolar noncompetitive inhibitors of protein kinase CK2.
    Prudent R; Moucadel V; Laudet B; Barette C; Lafanechère L; Hasenknopf B; Li J; Bareyt S; Lacôte E; Thorimbert S; Malacria M; Gouzerh P; Cochet C
    Chem Biol; 2008 Jul; 15(7):683-92. PubMed ID: 18635005
    [TBL] [Abstract][Full Text] [Related]  

  • 27. A quantitative analysis of kinase inhibitor selectivity.
    Karaman MW; Herrgard S; Treiber DK; Gallant P; Atteridge CE; Campbell BT; Chan KW; Ciceri P; Davis MI; Edeen PT; Faraoni R; Floyd M; Hunt JP; Lockhart DJ; Milanov ZV; Morrison MJ; Pallares G; Patel HK; Pritchard S; Wodicka LM; Zarrinkar PP
    Nat Biotechnol; 2008 Jan; 26(1):127-32. PubMed ID: 18183025
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Synthesis and biological evaluation of diversely substituted indolin-2-ones.
    Bouchikhi F; Rossignol E; Sancelme M; Aboab B; Anizon F; Fabbro D; Prudhomme M; Moreau P
    Eur J Med Chem; 2008 Nov; 43(11):2316-22. PubMed ID: 18313174
    [TBL] [Abstract][Full Text] [Related]  

  • 29. ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.
    Triola G; Wetzel S; Ellinger B; Koch MA; Hübel K; Rauh D; Waldmann H
    Bioorg Med Chem; 2009 Feb; 17(3):1079-87. PubMed ID: 18321716
    [TBL] [Abstract][Full Text] [Related]  

  • 30. A chemical genetic method for generating bivalent inhibitors of protein kinases.
    Hill ZB; Perera BG; Maly DJ
    J Am Chem Soc; 2009 May; 131(19):6686-8. PubMed ID: 19391594
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases.
    Nguyen TB; Lozach O; Surpateanu G; Wang Q; Retailleau P; Iorga BI; Meijer L; Guéritte F
    J Med Chem; 2012 Mar; 55(6):2811-9. PubMed ID: 22352892
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Access to resorcylic acid lactones via phosphonate based intramolecular olefination.
    Napolitano C; McArdle P; Murphy PV
    J Org Chem; 2010 Nov; 75(21):7404-7. PubMed ID: 20939525
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Fluorous mixture synthesis of 4-alkylidene cyclopentenones via a rhodium-catalyzed [2+2+1] cycloaddition of alkynyl allenes.
    Manku S; Curran DP
    J Comb Chem; 2005; 7(1):63-8. PubMed ID: 15638481
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Novel indole alpha-methylene-gamma-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases.
    Ding H; Zhang C; Wu X; Yang C; Zhang X; Ding J; Xie Y
    Bioorg Med Chem Lett; 2005 Nov; 15(21):4799-802. PubMed ID: 16143526
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Kinase inhibitor data modeling and de novo inhibitor design with fragment approaches.
    Vieth M; Erickson J; Wang J; Webster Y; Mader M; Higgs R; Watson I
    J Med Chem; 2009 Oct; 52(20):6456-66. PubMed ID: 19791746
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region.
    Laufer SA; Hauser DR; Domeyer DM; Kinkel K; Liedtke AJ
    J Med Chem; 2008 Jul; 51(14):4122-49. PubMed ID: 18578517
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent.
    Verheijen JC; Richard DJ; Curran K; Kaplan J; Lefever M; Nowak P; Malwitz DJ; Brooijmans N; Toral-Barza L; Zhang WG; Lucas J; Hollander I; Ayral-Kaloustian S; Mansour TS; Yu K; Zask A
    J Med Chem; 2009 Dec; 52(24):8010-24. PubMed ID: 19894727
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2.
    Wissner A; Fraser HL; Ingalls CL; Dushin RG; Floyd MB; Cheung K; Nittoli T; Ravi MR; Tan X; Loganzo F
    Bioorg Med Chem; 2007 Jun; 15(11):3635-48. PubMed ID: 17416531
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Kinase-targeted libraries: the design and synthesis of novel, potent, and selective kinase inhibitors.
    Akritopoulou-Zanze I; Hajduk PJ
    Drug Discov Today; 2009 Mar; 14(5-6):291-7. PubMed ID: 19121409
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Total synthesis of a 28-member stereoisomer library of murisolins.
    Curran DP; Zhang Q; Richard C; Lu H; Gudipati V; Wilcox CS
    J Am Chem Soc; 2006 Jul; 128(29):9561-73. PubMed ID: 16848495
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.