BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

426 related articles for article (PubMed ID: 19821576)

  • 1. Synthesis and evaluation of stable bidentate transition metal complexes of 1-(chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as hypoxia selective cytotoxins.
    Milbank JB; Stevenson RJ; Ware DC; Chang JY; Tercel M; Ahn GO; Wilson WR; Denny WA
    J Med Chem; 2009 Nov; 52(21):6822-34. PubMed ID: 19821576
    [TBL] [Abstract][Full Text] [Related]  

  • 2. N-alkylated cyclen cobalt(III) complexes of 1-(chloromethyl)-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugs.
    Lu GL; Stevenson RJ; Chang JY; Brothers PJ; Ware DC; Wilson WR; Denny WA; Tercel M
    Bioorg Med Chem; 2011 Aug; 19(16):4861-7. PubMed ID: 21775153
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.
    Hay MP; Anderson RF; Ferry DM; Wilson WR; Denny WA
    J Med Chem; 2003 Dec; 46(25):5533-45. PubMed ID: 14640560
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator.
    Ahn GO; Botting KJ; Patterson AV; Ware DC; Tercel M; Wilson WR
    Biochem Pharmacol; 2006 Jun; 71(12):1683-94. PubMed ID: 16620789
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: relationships between structure and cytotoxicity for analogues bearing different DNA minor groove binding subunits.
    Atwell GJ; Milbank JJ; Wilson WR; Hogg A; Denny WA
    J Med Chem; 1999 Aug; 42(17):3400-11. PubMed ID: 10464026
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis of 1-substituted 3-(chloromethyl)-6-aminoindoline (6-amino-seco-CI) DNA minor groove alkylating agents and structure-activity relationships for their cytotoxicity.
    Milbank JB; Tercel M; Atwell GJ; Wilson WR; Hogg A; Denny WA
    J Med Chem; 1999 Feb; 42(4):649-58. PubMed ID: 10052972
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cross-bridged cyclen or cyclam Co(III) complexes containing cytotoxic ligands as hypoxia-activated prodrugs.
    Chang JY; Lu GL; Stevenson RJ; Brothers PJ; Clark GR; Botting KJ; Ferry DM; Tercel M; Wilson WR; Denny WA; Ware DC
    Inorg Chem; 2013 Jul; 52(13):7688-98. PubMed ID: 23773210
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy.
    Stevenson RJ; Denny WA; Tercel M; Pruijn FB; Ashoorzadeh A
    J Med Chem; 2012 Mar; 55(6):2780-802. PubMed ID: 22339090
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Bis(dialkyl)dithiocarbamato cobalt(III) complexes of bidentate nitrogen mustards: synthesis, reduction chemistry and biological evaluation as hypoxia-selective cytotoxins.
    Ware DC; Palmer HR; Pruijn FB; Anderson RF; Brothers PJ; Denny WA; Wilson WR
    Anticancer Drug Des; 1998 Mar; 13(2):81-103. PubMed ID: 9524553
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A 2-nitroimidazole carbamate prodrug of 5-amimo-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbony l]-1,2-dihydro-3H--benz[E]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT.
    Hay MP; Sykes BM; Denny WA; Wilson WR
    Bioorg Med Chem Lett; 1999 Aug; 9(15):2237-42. PubMed ID: 10465553
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles.
    Ryu CK; Lee JY; Jeong SH; Nho JH
    Bioorg Med Chem Lett; 2009 Jan; 19(1):146-8. PubMed ID: 19010669
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hypoxia-activated prodrugs: substituent effects on the properties of nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) prodrugs of DNA minor groove alkylating agents.
    Tercel M; Atwell GJ; Yang S; Stevenson RJ; Botting KJ; Boyd M; Smith E; Anderson RF; Denny WA; Wilson WR; Pruijn FB
    J Med Chem; 2009 Nov; 52(22):7258-72. PubMed ID: 19877646
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.
    Hay MP; Atwell GJ; Wilson WR; Pullen SM; Denny WA
    J Med Chem; 2003 Jun; 46(12):2456-66. PubMed ID: 12773049
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycins.
    Ashoorzadeh A; Atwell GJ; Pruijn FB; Wilson WR; Tercel M; Denny WA; Stevenson RJ
    Bioorg Med Chem; 2011 Aug; 19(16):4851-60. PubMed ID: 21767954
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Preparation and antitumour properties of the enantiomers of a hypoxia-selective nitro analogue of the duocarmycins.
    Tercel M; Lee HH; Yang S; Liyanage HD; Mehta SY; Boyd PD; Jaiswal JK; Tan KL; Pruijn FB
    ChemMedChem; 2011 Oct; 6(10):1860-71. PubMed ID: 21793220
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and anti-cancer activity of 2,6-disubstituted N-methylpiperidine derivatives and their N-oxides.
    Henderson ND; Plumb JA; Robins DJ; Workman P
    Anticancer Drug Des; 1996 Sep; 11(6):421-38. PubMed ID: 8836108
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Radiosensitizing and toxic properties of quinoline and nitroquinoline complexes of platinum [PtCl2(NH3)quinoline].
    Skov KA; Adomat H; Doedee M; Farrell N
    Anticancer Drug Des; 1994 Apr; 9(2):103-17. PubMed ID: 8166927
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.
    Howard TT; Lingerfelt BM; Purnell BL; Scott AE; Price CA; Townes HM; McNulty L; Handl HL; Summerville K; Hudson SJ; Bowen JP; Kiakos K; Hartley JA; Lee M
    Bioorg Med Chem; 2002 Sep; 10(9):2941-52. PubMed ID: 12110316
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 1H-pyrrolo[2,3-f]quinoline and isoquinoline derivatives: synthesis and antiproliferative activity.
    Ferlin MG; Chiarelotto G; Basadonna O; Gia O; Mobilio S; Baccichetti F; Carlassare F
    Farmaco; 1989 Dec; 44(12):1141-55. PubMed ID: 2634405
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Optimization of the auxiliary ligand shell of Cobalt(III)(8-hydroxyquinoline) complexes as model hypoxia-selective radiation-activated prodrugs.
    Ahn GO; Ware DC; Denny WA; Wilson WR
    Radiat Res; 2004 Sep; 162(3):315-25. PubMed ID: 15333003
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 22.