These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

186 related articles for article (PubMed ID: 19824700)

  • 1. Thermodynamics of nucleotide and inhibitor binding to wild-type and ispinesib-resistant forms of human kinesin spindle protein.
    Sheth PR; Basso A; Duca JS; Lesburg CA; Ogas P; Gray K; Nale L; Mannarino AF; Prongay AJ; Le HV
    Biochemistry; 2009 Nov; 48(46):11045-55. PubMed ID: 19824700
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain.
    Sheth PR; Shipps GW; Seghezzi W; Smith CK; Chuang CC; Sanden D; Basso AD; Vilenchik L; Gray K; Annis DA; Nickbarg E; Ma Y; Lahue B; Herbst R; Le HV
    Biochemistry; 2010 Sep; 49(38):8350-8. PubMed ID: 20718440
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanism of inhibition of human KSP by ispinesib.
    Lad L; Luo L; Carson JD; Wood KW; Hartman JJ; Copeland RA; Sakowicz R
    Biochemistry; 2008 Mar; 47(11):3576-85. PubMed ID: 18290633
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Disparity in allosteric interactions of monastrol with Eg5 in the presence of ADP and ATP: a difference FT-IR investigation.
    Wojcik EJ; Dalrymple NA; Alford SR; Walker RA; Kim S
    Biochemistry; 2004 Aug; 43(31):9939-49. PubMed ID: 15287721
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition.
    Luo L; Carson JD; Dhanak D; Jackson JR; Huang PS; Lee Y; Sakowicz R; Copeland RA
    Biochemistry; 2004 Dec; 43(48):15258-66. PubMed ID: 15568818
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Monastrol inhibition of the mitotic kinesin Eg5.
    Cochran JC; Gatial JE; Kapoor TM; Gilbert SP
    J Biol Chem; 2005 Apr; 280(13):12658-67. PubMed ID: 15665380
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.
    Brier S; Lemaire D; Debonis S; Forest E; Kozielski F
    Biochemistry; 2004 Oct; 43(41):13072-82. PubMed ID: 15476401
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5.
    Maliga Z; Kapoor TM; Mitchison TJ
    Chem Biol; 2002 Sep; 9(9):989-96. PubMed ID: 12323373
    [TBL] [Abstract][Full Text] [Related]  

  • 9. "Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5.
    Kaan HY; Major J; Tkocz K; Kozielski F; Rosenfeld SS
    J Biol Chem; 2013 Jun; 288(25):18588-98. PubMed ID: 23658017
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents.
    Brier S; Lemaire D; DeBonis S; Forest E; Kozielski F
    J Mol Biol; 2006 Jul; 360(2):360-76. PubMed ID: 16780877
    [TBL] [Abstract][Full Text] [Related]  

  • 11. ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.
    Luo L; Parrish CA; Nevins N; McNulty DE; Chaudhari AM; Carson JD; Sudakin V; Shaw AN; Lehr R; Zhao H; Sweitzer S; Lad L; Wood KW; Sakowicz R; Annan RS; Huang PS; Jackson JR; Dhanak D; Copeland RA; Auger KR
    Nat Chem Biol; 2007 Nov; 3(11):722-6. PubMed ID: 17922005
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.
    DeBonis S; Simorre JP; Crevel I; Lebeau L; Skoufias DA; Blangy A; Ebel C; Gans P; Cross R; Hackney DD; Wade RH; Kozielski F
    Biochemistry; 2003 Jan; 42(2):338-49. PubMed ID: 12525161
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Progress on kinesin spindle protein inhibitors as anti-cancer agents.
    Zhang Y; Xu W
    Anticancer Agents Med Chem; 2008 Aug; 8(6):698-704. PubMed ID: 18690830
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator.
    Luo L; Carson JD; Molnar KS; Tuske SJ; Coales SJ; Hamuro Y; Sung CM; Sudakin V; Auger KR; Dhanak D; Jackson JR; Huang PS; Tummino PJ; Copeland RA
    J Am Chem Soc; 2008 Jun; 130(24):7584-91. PubMed ID: 18491908
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A structural model for monastrol inhibition of dimeric kinesin Eg5.
    Krzysiak TC; Wendt T; Sproul LR; Tittmann P; Gross H; Gilbert SP; Hoenger A
    EMBO J; 2006 May; 25(10):2263-73. PubMed ID: 16642039
    [TBL] [Abstract][Full Text] [Related]  

  • 16. STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity.
    Indorato RL; DeBonis S; Kozielski F; Garcia-Saez I; Skoufias DA
    Biochem Pharmacol; 2013 Nov; 86(10):1441-51. PubMed ID: 24041742
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of a mitotic motor protein: where, how, and conformational consequences.
    Yan Y; Sardana V; Xu B; Homnick C; Halczenko W; Buser CA; Schaber M; Hartman GD; Huber HE; Kuo LC
    J Mol Biol; 2004 Jan; 335(2):547-54. PubMed ID: 14672662
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Exploring a potential allosteric inhibition mechanism in the motor domain of human Eg-5.
    Nagarajan S; Sakkiah S
    J Biomol Struct Dyn; 2019 Jun; 37(9):2394-2403. PubMed ID: 30047307
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.
    Rickert KW; Schaber M; Torrent M; Neilson LA; Tasber ES; Garbaccio R; Coleman PJ; Harvey D; Zhang Y; Yang Y; Marshall G; Lee L; Walsh ES; Hamilton K; Buser CA
    Arch Biochem Biophys; 2008 Jan; 469(2):220-31. PubMed ID: 17999913
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner.
    Bell KM; Cha HK; Sindelar CV; Cochran JC
    J Biol Chem; 2017 Sep; 292(35):14680-14694. PubMed ID: 28701465
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.