BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

349 related articles for article (PubMed ID: 19852945)

  • 1. Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954.
    Prosser GA; Copp JN; Syddall SP; Williams EM; Smaill JB; Wilson WR; Patterson AV; Ackerley DF
    Biochem Pharmacol; 2010 Mar; 79(5):678-87. PubMed ID: 19852945
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.
    Prosser GA; Copp JN; Mowday AM; Guise CP; Syddall SP; Williams EM; Horvat CN; Swe PM; Ashoorzadeh A; Denny WA; Smaill JB; Patterson AV; Ackerley DF
    Biochem Pharmacol; 2013 Apr; 85(8):1091-103. PubMed ID: 23399641
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954.
    Jarrom D; Jaberipour M; Guise CP; Daff S; White SA; Searle PF; Hyde EI
    Biochemistry; 2009 Aug; 48(32):7665-72. PubMed ID: 19580253
    [TBL] [Abstract][Full Text] [Related]  

  • 4. E. coli nitroreductase/CB1954: in vitro studies into a potential system for feline cancer gene therapy.
    Blackwood L; O'Shaughnessy PJ; Reid SW; Argyle DJ
    Vet J; 2001 May; 161(3):269-79. PubMed ID: 11352484
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Direct positive selection for improved nitroreductase variants using SOS triggering of bacteriophage lambda lytic cycle.
    Guise CP; Grove JI; Hyde EI; Searle PF
    Gene Ther; 2007 Apr; 14(8):690-8. PubMed ID: 17301844
    [TBL] [Abstract][Full Text] [Related]  

  • 6. E. coli nitroreductase/CB1954 gene-directed enzyme prodrug therapy: role of arylamine N-acetlytransferase 2.
    Mitchell DJ; Minchin RF
    Cancer Gene Ther; 2008 Nov; 15(11):758-64. PubMed ID: 18600257
    [TBL] [Abstract][Full Text] [Related]  

  • 7. uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954.
    Prosser GA; Patterson AV; Ackerley DF
    J Biotechnol; 2010 Oct; 150(1):190-4. PubMed ID: 20727918
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.
    Grove JI; Lovering AL; Guise C; Race PR; Wrighton CJ; White SA; Hyde EI; Searle PF
    Cancer Res; 2003 Sep; 63(17):5532-7. PubMed ID: 14500391
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene.
    Green NK; Youngs DJ; Neoptolemos JP; Friedlos F; Knox RJ; Springer CJ; Anlezark GM; Michael NP; Melton RG; Ford MJ; Young LS; Kerr DJ; Searle PF
    Cancer Gene Ther; 1997; 4(4):229-38. PubMed ID: 9253508
    [TBL] [Abstract][Full Text] [Related]  

  • 10. E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954.
    Vass SO; Jarrom D; Wilson WR; Hyde EI; Searle PF
    Br J Cancer; 2009 Jun; 100(12):1903-11. PubMed ID: 19455141
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: a well-tolerated therapy for established solid tumors.
    Djeha AH; Thomson TA; Leung H; Searle PF; Young LS; Kerr DJ; Harris PA; Mountain A; Wrighton CJ
    Mol Ther; 2001 Feb; 3(2):233-40. PubMed ID: 11237680
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanism of CB1954 reduction by Escherichia coli nitroreductase.
    Christofferson A; Wilkie J
    Biochem Soc Trans; 2009 Apr; 37(Pt 2):413-8. PubMed ID: 19290872
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.
    Drabek D; Guy J; Craig R; Grosveld F
    Gene Ther; 1997 Feb; 4(2):93-100. PubMed ID: 9081711
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Virus-directed enzyme prodrug therapy using CB1954.
    Grove JI; Searle PF; Weedon SJ; Green NK; McNeish IA; Kerr DJ
    Anticancer Drug Des; 1999 Dec; 14(6):461-72. PubMed ID: 10834268
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954.
    Race PR; Lovering AL; White SA; Grove JI; Searle PF; Wrighton CW; Hyde EI
    J Mol Biol; 2007 Apr; 368(2):481-92. PubMed ID: 17350040
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.
    Searle PF; Chen MJ; Hu L; Race PR; Lovering AL; Grove JI; Guise C; Jaberipour M; James ND; Mautner V; Young LS; Kerr DJ; Mountain A; White SA; Hyde EI
    Clin Exp Pharmacol Physiol; 2004 Nov; 31(11):811-6. PubMed ID: 15566399
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.
    Hay MP; Anderson RF; Ferry DM; Wilson WR; Denny WA
    J Med Chem; 2003 Dec; 46(25):5533-45. PubMed ID: 14640560
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector.
    Chen MJ; Green NK; Reynolds GM; Flavell JR; Mautner V; Kerr DJ; Young LS; Searle PF
    Gene Ther; 2004 Jul; 11(14):1126-36. PubMed ID: 15164095
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Investigation of alternative prodrugs for use with E. coli nitroreductase in 'suicide gene' approaches to cancer therapy.
    Bailey SM; Knox RJ; Hobbs SM; Jenkins TC; Mauger AB; Melton RG; Burke PJ; Connors TA; Hart IR
    Gene Ther; 1996 Dec; 3(12):1143-50. PubMed ID: 8986441
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Towards gene therapy in prosthesis loosening: efficient killing of interface cells by gene-directed enzyme prodrug therapy with nitroreductase and the prodrug CB1954.
    de Poorter JJ; Tolboom TC; Rabelink MJ; Pieterman E; Hoeben RC; Nelissen RG; Huizinga TW
    J Gene Med; 2005 Nov; 7(11):1421-8. PubMed ID: 15977303
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.