BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

277 related articles for article (PubMed ID: 19857798)

  • 1. Considerations regarding a permitted daily exposure calculation for ethyl methanesulfonate.
    Müller L; Gocke E
    Toxicol Lett; 2009 Nov; 190(3):330-2. PubMed ID: 19857798
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.
    Müller L; Gocke E; Lavé T; Pfister T
    Toxicol Lett; 2009 Nov; 190(3):317-29. PubMed ID: 19443141
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The Viracept (nelfinavir)--ethyl methanesulfonate case: a threshold risk assessment for human exposure to a genotoxic drug contamination?
    Lutz WK
    Toxicol Lett; 2009 Nov; 190(3):239-42. PubMed ID: 19695319
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Modelling of patient EMS exposure: translating pharmacokinetics of EMS in vitro and in animals into patients.
    Lavé T; Paehler A; Grimm HP; Gocke E; Müller L
    Toxicol Lett; 2009 Nov; 190(3):310-6. PubMed ID: 19695316
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Literature review on the genotoxicity, reproductive toxicity, and carcinogenicity of ethyl methanesulfonate.
    Gocke E; Bürgin H; Müller L; Pfister T
    Toxicol Lett; 2009 Nov; 190(3):254-65. PubMed ID: 19857796
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity.
    Müller L; Mauthe RJ; Riley CM; Andino MM; Antonis DD; Beels C; DeGeorge J; De Knaep AG; Ellison D; Fagerland JA; Frank R; Fritschel B; Galloway S; Harpur E; Humfrey CD; Jacks AS; Jagota N; Mackinnon J; Mohan G; Ness DK; O'Donovan MR; Smith MD; Vudathala G; Yotti L
    Regul Toxicol Pharmacol; 2006 Apr; 44(3):198-211. PubMed ID: 16412543
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Principles of risk assessment for determining the safety of chemicals: recent assessment of residual solvents in drugs and di(2-ethylhexyl) phthalate.
    Hasegawa R; Koizumi M; Hirose A
    Congenit Anom (Kyoto); 2004 Jun; 44(2):51-9. PubMed ID: 15198717
    [TBL] [Abstract][Full Text] [Related]  

  • 8. EMS in Viracept--the course of events in 2007 and 2008 from the non-clinical safety point of view.
    Müller L; Singer T
    Toxicol Lett; 2009 Nov; 190(3):243-7. PubMed ID: 19857794
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In vivo genotoxicity of EMS: statistical assessment of the dose response curves.
    Gocke E; Wall M
    Toxicol Lett; 2009 Nov; 190(3):298-302. PubMed ID: 19857797
    [TBL] [Abstract][Full Text] [Related]  

  • 10. MNT and MutaMouse studies to define the in vivo dose response relations of the genotoxicity of EMS and ENU.
    Gocke E; Ballantyne M; Whitwell J; Müller L
    Toxicol Lett; 2009 Nov; 190(3):286-97. PubMed ID: 19446969
    [TBL] [Abstract][Full Text] [Related]  

  • 11. EMS in Viracept--initial ('traditional') assessment of risk to patients based on linear dose response relations.
    Gocke E; Müller L; Pfister T
    Toxicol Lett; 2009 Nov; 190(3):266-70. PubMed ID: 19439165
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Setting health-based residue limits for contaminants in pharmaceuticals and medical devices.
    Conine DL; Naumann BD; Hecker LH
    Qual Assur; 1992 Jun; 1(3):171-80. PubMed ID: 1344672
    [TBL] [Abstract][Full Text] [Related]  

  • 13. In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.
    Gocke E; Müller L
    Mutat Res; 2009 Aug; 678(2):101-7. PubMed ID: 19376265
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Assessment of the genotoxic and carcinogenic risks of p-nitrophenol when it is present as an impurity in a drug product.
    Eichenbaum G; Johnson M; Kirkland D; O'Neill P; Stellar S; Bielawne J; DeWire R; Areia D; Bryant S; Weiner S; Desai-Krieger D; Guzzie-Peck P; Evans DC; Tonelli A
    Regul Toxicol Pharmacol; 2009 Oct; 55(1):33-42. PubMed ID: 19500632
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Recent developments in the risk assessment of potentially genotoxic impurities in pharmaceutical drug substances.
    Humfrey CD
    Toxicol Sci; 2007 Nov; 100(1):24-8. PubMed ID: 17656486
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vivo and in vitro characterization of ethyl methanesulfonate pharmacokinetics in animals and in human.
    Lavé T; Birnböck H; Götschi A; Ramp T; Pähler A
    Toxicol Lett; 2009 Nov; 190(3):303-9. PubMed ID: 19695315
    [TBL] [Abstract][Full Text] [Related]  

  • 17. General 4-week toxicity study with EMS in the rat.
    Pfister T; Eichinger-Chapelon A
    Toxicol Lett; 2009 Nov; 190(3):271-85. PubMed ID: 19442710
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Non-linear dose-response of DNA-reactive genotoxins: recommendations for data analysis.
    Johnson GE; Doak SH; Griffiths SM; Quick EL; Skibinski DO; Zaïr ZM; Jenkins GJ
    Mutat Res; 2009 Aug; 678(2):95-100. PubMed ID: 19467345
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Overview of genotoxic impurities in pharmaceutical development.
    Bercu JP; Dobo KL; Gocke E; McGovern TJ
    Int J Toxicol; 2009; 28(6):468-78. PubMed ID: 19966139
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Special endpoint and product specific considerations in pharmaceutical acceptable daily exposure derivation.
    Gould J; Callis CM; Dolan DG; Stanard B; Weideman PA
    Regul Toxicol Pharmacol; 2016 Aug; 79 Suppl 1():S79-93. PubMed ID: 27233924
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.