320 related articles for article (PubMed ID: 19863156)
1. Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization.
Khrapunovich-Baine M; Menon V; Verdier-Pinard P; Smith AB; Angeletti RH; Fiser A; Horwitz SB; Xiao H
Biochemistry; 2009 Dec; 48(49):11664-77. PubMed ID: 19863156
[TBL] [Abstract][Full Text] [Related]
2. A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin.
Xia S; Kenesky CS; Rucker PV; Smith AB; Orr GA; Horwitz SB
Biochemistry; 2006 Oct; 45(39):11762-75. PubMed ID: 17002277
[TBL] [Abstract][Full Text] [Related]
3. Structural Basis of Microtubule Stabilization by Discodermolide.
Prota AE; Bargsten K; Redondo-Horcajo M; Smith AB; Yang CH; McDaid HM; Paterson I; Horwitz SB; Fernando Díaz J; Steinmetz MO
Chembiochem; 2017 May; 18(10):905-909. PubMed ID: 28207984
[TBL] [Abstract][Full Text] [Related]
4. Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach.
Canales A; Rodríguez-Salarichs J; Trigili C; Nieto L; Coderch C; Andreu JM; Paterson I; Jiménez-Barbero J; Díaz JF
ACS Chem Biol; 2011 Aug; 6(8):789-99. PubMed ID: 21539341
[TBL] [Abstract][Full Text] [Related]
5. Differential effects of natural product microtubule stabilizers on microtubule assembly: single agent and combination studies with taxol, epothilone B, and discodermolide.
Gertsch J; Meier S; Müller M; Altmann KH
Chembiochem; 2009 Jan; 10(1):166-75. PubMed ID: 19058273
[TBL] [Abstract][Full Text] [Related]
6. The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.
Kowalski RJ; Giannakakou P; Gunasekera SP; Longley RE; Day BW; Hamel E
Mol Pharmacol; 1997 Oct; 52(4):613-22. PubMed ID: 9380024
[TBL] [Abstract][Full Text] [Related]
7. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest.
Hung DT; Chen J; Schreiber SL
Chem Biol; 1996 Apr; 3(4):287-93. PubMed ID: 8807856
[TBL] [Abstract][Full Text] [Related]
8. Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.
Khrapunovich-Baine M; Menon V; Yang CP; Northcote PT; Miller JH; Angeletti RH; Fiser A; Horwitz SB; Xiao H
J Biol Chem; 2011 Apr; 286(13):11765-78. PubMed ID: 21245138
[TBL] [Abstract][Full Text] [Related]
9. Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells.
Honore S; Kamath K; Braguer D; Horwitz SB; Wilson L; Briand C; Jordan MA
Cancer Res; 2004 Jul; 64(14):4957-64. PubMed ID: 15256469
[TBL] [Abstract][Full Text] [Related]
10. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.
ter Haar E; Kowalski RJ; Hamel E; Lin CM; Longley RE; Gunasekera SP; Rosenkranz HS; Day BW
Biochemistry; 1996 Jan; 35(1):243-50. PubMed ID: 8555181
[TBL] [Abstract][Full Text] [Related]
11. Insights into the mechanism of microtubule stabilization by Taxol.
Xiao H; Verdier-Pinard P; Fernandez-Fuentes N; Burd B; Angeletti R; Fiser A; Horwitz SB; Orr GA
Proc Natl Acad Sci U S A; 2006 Jul; 103(27):10166-10173. PubMed ID: 16801540
[TBL] [Abstract][Full Text] [Related]
12. Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.
Paterson I; Naylor GJ; Fujita T; Guzmán E; Wright AE
Chem Commun (Camb); 2010 Jan; 46(2):261-3. PubMed ID: 20024345
[TBL] [Abstract][Full Text] [Related]
13. Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.
Buey RM; Calvo E; Barasoain I; Pineda O; Edler MC; Matesanz R; Cerezo G; Vanderwal CD; Day BW; Sorensen EJ; López JA; Andreu JM; Hamel E; Díaz JF
Nat Chem Biol; 2007 Feb; 3(2):117-25. PubMed ID: 17206139
[TBL] [Abstract][Full Text] [Related]
14. The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide.
Sánchez-Pedregal VM; Kubicek K; Meiler J; Lyothier I; Paterson I; Carlomagno T
Angew Chem Int Ed Engl; 2006 Nov; 45(44):7388-94. PubMed ID: 17036370
[No Abstract] [Full Text] [Related]
15. The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies.
Martello LA; LaMarche MJ; He L; Beauchamp TJ; Smith AB; Horwitz SB
Chem Biol; 2001 Sep; 8(9):843-55. PubMed ID: 11564553
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin.
Qi J; Blanden AR; Bane S; Kingston DG
Bioorg Med Chem; 2011 Sep; 19(17):5247-54. PubMed ID: 21802957
[TBL] [Abstract][Full Text] [Related]
17. Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence.
Guo B; Rodriguez-Gabin A; Prota AE; Mühlethaler T; Zhang N; Ye K; Steinmetz MO; Horwitz SB; Smith AB; McDaid HM
Mol Pharmacol; 2020 Aug; 98(2):156-167. PubMed ID: 32591477
[TBL] [Abstract][Full Text] [Related]
18. A unique mode of microtubule stabilization induced by peloruside A.
Huzil JT; Chik JK; Slysz GW; Freedman H; Tuszynski J; Taylor RE; Sackett DL; Schriemer DC
J Mol Biol; 2008 May; 378(5):1016-30. PubMed ID: 18405918
[TBL] [Abstract][Full Text] [Related]
19. Taxol
Yang CH; Horwitz SB
Int J Mol Sci; 2017 Aug; 18(8):. PubMed ID: 28792473
[TBL] [Abstract][Full Text] [Related]
20. Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.
Madiraju C; Edler MC; Hamel E; Raccor BS; Balachandran R; Zhu G; Giuliano KA; Vogt A; Shin Y; Fournier JH; Fukui Y; Brückner AM; Curran DP; Day BW
Biochemistry; 2005 Nov; 44(45):15053-63. PubMed ID: 16274252
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]