BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

249 related articles for article (PubMed ID: 19883083)

  • 1. 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.
    Dexheimer TS; Gediya LK; Stephen AG; Weidlich I; Antony S; Marchand C; Interthal H; Nicklaus M; Fisher RJ; Njar VC; Pommier Y
    J Med Chem; 2009 Nov; 52(22):7122-31. PubMed ID: 19883083
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.
    Dexheimer TS; Antony S; Marchand C; Pommier Y
    Anticancer Agents Med Chem; 2008 May; 8(4):381-9. PubMed ID: 18473723
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1.
    Antony S; Marchand C; Stephen AG; Thibaut L; Agama KK; Fisher RJ; Pommier Y
    Nucleic Acids Res; 2007; 35(13):4474-84. PubMed ID: 17576665
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
    Zhang XR; Wang HW; Tang WL; Zhang Y; Yang H; Hu DX; Ravji A; Marchand C; Kiselev E; Ofori-Atta K; Agama K; Pommier Y; An LK
    J Med Chem; 2018 Nov; 61(22):9908-9930. PubMed ID: 30336023
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer.
    Hu DX; Tang WL; Zhang Y; Yang H; Wang W; Agama K; Pommier Y; An LK
    J Med Chem; 2021 Jun; 64(11):7617-7629. PubMed ID: 34008967
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.
    Sirivolu VR; Vernekar SK; Marchand C; Naumova A; Chergui A; Renaud A; Stephen AG; Chen F; Sham YY; Pommier Y; Wang Z
    J Med Chem; 2012 Oct; 55(20):8671-84. PubMed ID: 23006064
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.
    Nguyen TX; Morrell A; Conda-Sheridan M; Marchand C; Agama K; Bermingham A; Bermingam A; Stephen AG; Chergui A; Naumova A; Fisher R; O'Keefe BR; Pommier Y; Cushman M
    J Med Chem; 2012 May; 55(9):4457-78. PubMed ID: 22536944
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2
    Li-Zhulanov NS; Zakharenko AL; Chepanova AA; Patel J; Zafar A; Volcho KP; Salakhutdinov NF; Reynisson J; Leung IKH; Lavrik OI
    Molecules; 2018 Sep; 23(10):. PubMed ID: 30261631
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1.
    El-Khamisy SF; Saifi GM; Weinfeld M; Johansson F; Helleday T; Lupski JR; Caldecott KW
    Nature; 2005 Mar; 434(7029):108-13. PubMed ID: 15744309
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.
    Zakharova O; Luzina O; Zakharenko A; Sokolov D; Filimonov A; Dyrkheeva N; Chepanova A; Ilina E; Ilyina A; Klabenkova K; Chelobanov B; Stetsenko D; Zafar A; Eurtivong C; Reynisson J; Volcho K; Salakhutdinov N; Lavrik O
    Bioorg Med Chem; 2018 Aug; 26(15):4470-4480. PubMed ID: 30076000
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.
    Murai J; Marchand C; Shahane SA; Sun H; Huang R; Zhang Y; Chergui A; Ji J; Doroshow JH; Jadhav A; Takeda S; Xia M; Pommier Y
    DNA Repair (Amst); 2014 Sep; 21():177-82. PubMed ID: 24794403
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors.
    Huang SN; Pommier Y; Marchand C
    Expert Opin Ther Pat; 2011 Sep; 21(9):1285-92. PubMed ID: 21843105
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).
    Conda-Sheridan M; Reddy PV; Morrell A; Cobb BT; Marchand C; Agama K; Chergui A; Renaud A; Stephen AG; Bindu LK; Pommier Y; Cushman M
    J Med Chem; 2013 Jan; 56(1):182-200. PubMed ID: 23259865
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage.
    Comeaux EQ; Cuya SM; Kojima K; Jafari N; Wanzeck KC; Mobley JA; Bjornsti MA; van Waardenburg RC
    J Biol Chem; 2015 Mar; 290(10):6203-14. PubMed ID: 25609251
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.
    Walker S; Meisenberg C; Bibby RA; Askwith T; Williams G; Rininsland FH; Pearl LH; Oliver AW; El-Khamisy S; Ward S; Atack JR
    Anal Biochem; 2014 Jun; 454(100):17-22. PubMed ID: 24637157
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and Biological Activities of 11- and 12-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.
    Yang H; Qin C; Wu M; Wang FT; Wang W; Agama K; Pommier Y; Hu DX; An LK
    ChemMedChem; 2023 May; 18(10):e202200593. PubMed ID: 36932053
    [TBL] [Abstract][Full Text] [Related]  

  • 17. New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2.
    Salomatina OV; Dyrkheeva NS; Popadyuk II; Zakharenko AL; Ilina ES; Komarova NI; Reynisson J; Salakhutdinov NF; Lavrik OI; Volcho KP
    Molecules; 2021 Dec; 27(1):. PubMed ID: 35011303
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures.
    Davies DR; Interthal H; Champoux JJ; Hol WG
    J Mol Biol; 2002 Dec; 324(5):917-32. PubMed ID: 12470949
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors.
    Jakobsen AK; Keller JG; Gonzalez M; Martin-Encinas E; Palacios F; Alonso C; Knudsen BR; Stougaard M
    Sensors (Basel); 2021 Jul; 21(14):. PubMed ID: 34300575
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors.
    Lv PC; Agama K; Marchand C; Pommier Y; Cushman M
    J Med Chem; 2014 May; 57(10):4324-36. PubMed ID: 24800942
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.