These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

108 related articles for article (PubMed ID: 1989494)

  • 1. Effect of single amino acid substitutions at positions 49 and 60 on the thermal unfolding of the tryptophan synthase alpha subunit from Salmonella typhimurium.
    Kanzaki H; McPhie P; Miles EW
    Arch Biochem Biophys; 1991 Jan; 284(1):174-80. PubMed ID: 1989494
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The alpha subunit of tryptophan synthase. Evidence that aspartic acid 60 is a catalytic residue and that the double alteration of residues 175 and 211 in a second-site revertant restores the proper geometry of the substrate binding site.
    Nagata S; Hyde CC; Miles EW
    J Biol Chem; 1989 Apr; 264(11):6288-96. PubMed ID: 2649498
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A tightly packed hydrophobic cluster directs the formation of an off-pathway sub-millisecond folding intermediate in the alpha subunit of tryptophan synthase, a TIM barrel protein.
    Wu Y; Vadrevu R; Kathuria S; Yang X; Matthews CR
    J Mol Biol; 2007 Mar; 366(5):1624-38. PubMed ID: 17222865
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mutagenic analysis of the interior packing of an alpha/beta barrel protein. Effects on the stabilities and rates of interconversion of the native and partially folded forms of the alpha subunit of tryptophan synthase.
    Tsuji T; Chrunyk BA; Chen X; Matthews CR
    Biochemistry; 1993 Jun; 32(21):5566-75. PubMed ID: 8504078
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Amino acid replacements can selectively affect the interaction energy of autonomous folding units in the alpha subunit of tryptophan synthase.
    Chen X; Rambo R; Matthews CR
    Biochemistry; 1992 Mar; 31(8):2219-23. PubMed ID: 1540577
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A thermodynamic analysis of conformational change due to the alpha 2 beta 2 complex formation of tryptophan synthase.
    Hiraga K; Yutani K
    Eur J Biochem; 1996 Aug; 240(1):63-70. PubMed ID: 8797836
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Circular dichroism studies of the coenzyme environment in the active sites of mutant forms of the beta-subunit in the tryptophan synthase alpha 2 beta 2 complex.
    Kayastha AM; Sawa Y; Nagata S; Kanzaki H; Miles EW
    Indian J Biochem Biophys; 1991; 28(5-6):352-7. PubMed ID: 1812066
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Substitution of glutamic acid 109 by aspartic acid alters the substrate specificity and catalytic activity of the beta-subunit in the tryptophan synthase bienzyme complex from Salmonella typhimurium.
    Brzović PS; Kayastha AM; Miles EW; Dunn MF
    Biochemistry; 1992 Feb; 31(4):1180-90. PubMed ID: 1346502
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Equilibrium and kinetic analyses of unfolding and refolding for the conserved proline mutants of tryptophan synthase alpha subunit.
    Ogasahara K; Yutani K
    Biochemistry; 1997 Jan; 36(4):932-40. PubMed ID: 9020793
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effects of the phenylalanine-22----leucine, glutamic acid-49----methionine, glycine-234----aspartic acid, and glycine-234----lysine mutations on the folding and stability of the alpha subunit of tryptophan synthase from Escherichia coli.
    Beasty AM; Hurle MR; Manz JT; Stackhouse T; Onuffer JJ; Matthews CR
    Biochemistry; 1986 May; 25(10):2965-74. PubMed ID: 2872918
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Relative activities and stabilities of mutant Escherichia coli tryptophan synthase alpha subunits.
    Lim WK; Shin HJ; Milton DL; Hardman JK
    J Bacteriol; 1991 Mar; 173(6):1886-93. PubMed ID: 2001993
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Site-directed mutagenesis of the beta subunit of tryptophan synthase from Salmonella typhimurium. Role of active site glutamic acid 350.
    Kayastha AM; Sawa Y; Nagata S; Miles EW
    J Biol Chem; 1991 Apr; 266(12):7618-25. PubMed ID: 1673461
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of the functional role of a flexible loop in the alpha-subunit of tryptophan synthase from Salmonella typhimurium by rapid-scanning, stopped-flow spectroscopy and site-directed mutagenesis.
    Brzović PS; Hyde CC; Miles EW; Dunn MF
    Biochemistry; 1993 Oct; 32(39):10404-13. PubMed ID: 8399184
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Thermal stabilities of mutant Escherichia coli tryptophan synthase alpha subunits.
    Lim WK; Brouillette C; Hardman JK
    Arch Biochem Biophys; 1992 Jan; 292(1):34-41. PubMed ID: 1727648
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conformational changes in the alpha-subunit coupled to binding of the beta 2-subunit of tryptophan synthase from Escherichia coli: crystal structure of the tryptophan synthase alpha-subunit alone.
    Nishio K; Morimoto Y; Ishizuka M; Ogasahara K; Tsukihara T; Yutani K
    Biochemistry; 2005 Feb; 44(4):1184-92. PubMed ID: 15667212
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of conserved proline residues in stabilizing tryptophan synthase alpha subunit: analysis by mutants with alanine or glycine.
    Yutani K; Hayashi S; Sugisaki Y; Ogasahara K
    Proteins; 1991; 9(2):90-8. PubMed ID: 2008436
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Local and long-range interactions in the thermal unfolding transition of bovine pancreatic ribonuclease A.
    Navon A; Ittah V; Laity JH; Scheraga HA; Haas E; Gussakovsky EE
    Biochemistry; 2001 Jan; 40(1):93-104. PubMed ID: 11141060
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Long-range side-chain-main-chain interactions play crucial roles in stabilizing the (betaalpha)8 barrel motif of the alpha subunit of tryptophan synthase.
    Yang X; Vadrevu R; Wu Y; Matthews CR
    Protein Sci; 2007 Jul; 16(7):1398-409. PubMed ID: 17586773
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Acid-induced molten globule state of a fully active mutant of human interleukin-6.
    De Filippis V; de Laureto PP; Toniutti N; Fontana A
    Biochemistry; 1996 Sep; 35(35):11503-11. PubMed ID: 8784206
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure and function of the tryptophan synthase alpha(2)beta(2) complex. Roles of beta subunit histidine 86.
    Ro HS; Miles EW
    J Biol Chem; 1999 Dec; 274(51):36439-45. PubMed ID: 10593940
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.