BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

176 related articles for article (PubMed ID: 19895504)

  • 1. Shape- and chemical feature-based 3D-pharmacophore model generation and virtual screening: identification of potential leads for P. falciparum DHFR enzyme inhibition.
    Adane L; Patel DS; Bharatam PV
    Chem Biol Drug Des; 2010 Jan; 75(1):115-26. PubMed ID: 19895504
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A common feature-based 3D-pharmacophore model generation and virtual screening: identification of potential PfDHFR inhibitors.
    Adane L; Bharatam PV; Sharma V
    J Enzyme Inhib Med Chem; 2010 Oct; 25(5):635-45. PubMed ID: 19995305
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Plasmodium falciparum: kinetic interactions of WR99210 with pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase.
    Hekmat-Nejad M; Rathod PK
    Exp Parasitol; 1997 Nov; 87(3):222-8. PubMed ID: 9371087
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of the optimal third generation antifolate against P. falciparum and P. vivax.
    Hunt SY; Detering C; Varani G; Jacobus DP; Schiehser GA; Shieh HM; Nevchas I; Terpinski J; Sibley CH
    Mol Biochem Parasitol; 2005 Dec; 144(2):198-205. PubMed ID: 16181688
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In silico screening against wild-type and mutant Plasmodium falciparum dihydrofolate reductase.
    Fogel GB; Cheung M; Pittman E; Hecht D
    J Mol Graph Model; 2008 Apr; 26(7):1145-52. PubMed ID: 18037315
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase.
    Kamchonwongpaisan S; Vanichtanankul J; Taweechai S; Chitnumsub P; Yuthavong Y
    Int J Parasitol; 2007 Jun; 37(7):787-93. PubMed ID: 17320089
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel alleles of Plasmodium falciparum dhfr that confer resistance to chlorcycloguanil.
    Hunt SY; Rezvani BB; Sibley CH
    Mol Biochem Parasitol; 2005 Jan; 139(1):25-32. PubMed ID: 15610816
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach.
    Parenti MD; Pacchioni S; Ferrari AM; Rastelli G
    J Med Chem; 2004 Aug; 47(17):4258-67. PubMed ID: 15293997
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular dynamics of interactions between rigid and flexible antifolates and dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium falciparum.
    Mokmak W; Chunsrivirot S; Hannongbua S; Yuthavong Y; Tongsima S; Kamchonwongpaisan S
    Chem Biol Drug Des; 2014 Oct; 84(4):450-61. PubMed ID: 24716467
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 3D-QSAR analysis of cycloguanil derivatives as inhibitors of A16V + S108T mutant Plasmodium falciparum dihydrofolate reductase enzyme.
    Adane L; Bharatam PV
    J Mol Graph Model; 2009 Nov; 28(4):357-67. PubMed ID: 19796975
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Plasmodium falciparum: asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant.
    Sirawaraporn W; Yongkiettrakul S; Sirawaraporn R; Yuthavong Y; Santi DV
    Exp Parasitol; 1997 Nov; 87(3):245-52. PubMed ID: 9371090
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Use of a semi-nested PCR diagnosis test to evaluate antifolate resistance of Plasmodium falciparum isolates.
    Eldin de Pecoulas P; Abdallah B; Dje MK; Basco LK; le Bras J; Mazabraud A
    Mol Cell Probes; 1995 Dec; 9(6):391-7. PubMed ID: 8808309
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Translational up-regulation of antifolate drug targets in the human malaria parasite Plasmodium falciparum upon challenge with inhibitors.
    Nirmalan N; Sims PF; Hyde JE
    Mol Biochem Parasitol; 2004 Jul; 136(1):63-70. PubMed ID: 15138068
    [TBL] [Abstract][Full Text] [Related]  

  • 14. DHFR and DHPS genotypes of Plasmodium falciparum isolates from Gabon correlate with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine-pyrimethamine treatment efficacy.
    Aubouy A; Jafari S; Huart V; Migot-Nabias F; Mayombo J; Durand R; Bakary M; Le Bras J; Deloron P
    J Antimicrob Chemother; 2003 Jul; 52(1):43-9. PubMed ID: 12805261
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.
    Kamchonwongpaisan S; Vanichtanankul J; Tarnchompoo B; Yuvaniyama J; Taweechai S; Yuthavong Y
    Anal Chem; 2005 Mar; 77(5):1222-7. PubMed ID: 15732900
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Insights into antifolate resistance from malarial DHFR-TS structures.
    Yuvaniyama J; Chitnumsub P; Kamchonwongpaisan S; Vanichtanankul J; Sirawaraporn W; Taylor P; Walkinshaw MD; Yuthavong Y
    Nat Struct Biol; 2003 May; 10(5):357-65. PubMed ID: 12704428
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.
    McKie JH; Douglas KT; Chan C; Roser SA; Yates R; Read M; Hyde JE; Dascombe MJ; Yuthavong Y; Sirawaraporn W
    J Med Chem; 1998 Apr; 41(9):1367-70. PubMed ID: 9554869
    [TBL] [Abstract][Full Text] [Related]  

  • 18. QSAR using evolved neural networks for the inhibition of mutant PfDHFR by pyrimethamine derivatives.
    Hecht D; Cheung M; Fogel GB
    Biosystems; 2008 Apr; 92(1):10-5. PubMed ID: 18160210
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs.
    Auliff A; Wilson DW; Russell B; Gao Q; Chen N; Anh le N; Maguire J; Bell D; O'Neil MT; Cheng Q
    Am J Trop Med Hyg; 2006 Oct; 75(4):617-21. PubMed ID: 17038682
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Trypanosomal dihydrofolate reductase reveals natural antifolate resistance.
    Vanichtanankul J; Taweechai S; Yuvaniyama J; Vilaivan T; Chitnumsub P; Kamchonwongpaisan S; Yuthavong Y
    ACS Chem Biol; 2011 Sep; 6(9):905-11. PubMed ID: 21650210
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.