BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

61 related articles for article (PubMed ID: 19914076)

  • 21. Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.
    Huang H; Hutta DA; Rinker JM; Hu H; Parsons WH; Schubert C; DesJarlais RL; Crysler CS; Chaikin MA; Donatelli RR; Chen Y; Cheng D; Zhou Z; Yurkow E; Manthey CL; Player MR
    J Med Chem; 2009 Feb; 52(4):1081-99. PubMed ID: 19193011
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes.
    Lee YR; Lee JH; Noh EM; Kim EK; Song MY; Jung WS; Park SJ; Kim JS; Park JW; Kwon KB; Park BH
    Life Sci; 2008 Jun; 82(23-24):1203-9. PubMed ID: 18495175
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors.
    Newton R; Holden NS; Catley MC; Oyelusi W; Leigh R; Proud D; Barnes PJ
    J Pharmacol Exp Ther; 2007 May; 321(2):734-42. PubMed ID: 17322026
    [TBL] [Abstract][Full Text] [Related]  

  • 24. TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo.
    Wisniewski HG; Hua JC; Poppers DM; Naime D; Vilcek J; Cronstein BN
    J Immunol; 1996 Feb; 156(4):1609-15. PubMed ID: 8568267
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta).
    Christopher JA; Bamborough P; Alder C; Campbell A; Cutler GJ; Down K; Hamadi AM; Jolly AM; Kerns JK; Lucas FS; Mellor GW; Miller DD; Morse MA; Pancholi KD; Rumsey W; Solanke YE; Williamson R
    J Med Chem; 2009 May; 52(9):3098-102. PubMed ID: 19348415
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Identification of human IKK-2 inhibitors of natural origin (Part II): in Silico prediction of IKK-2 inhibitors in natural extracts with known anti-inflammatory activity.
    Sala E; Guasch L; Iwaszkiewicz J; Mulero M; Salvadó MJ; Bladé C; Ceballos M; Valls C; Zoete V; Grosdidier A; Garcia-Vallvé S; Michielin O; Pujadas G
    Eur J Med Chem; 2011 Dec; 46(12):6098-103. PubMed ID: 22000921
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.
    Gillooly KM; Pattoli MA; Taylor TL; Chen L; Cheng L; Gregor KR; Whitney GS; Susulic V; Watterson SH; Kempson J; Pitts WJ; Booth-Lute H; Yang G; Davies P; Kukral DW; Strnad J; McIntyre KW; Darienzo CJ; Salter-Cid L; Yang Z; Wang-Iverson DB; Burke JR
    J Pharmacol Exp Ther; 2009 Nov; 331(2):349-60. PubMed ID: 19652024
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.
    Kempson J; Guo J; Das J; Moquin RV; Spergel SH; Watterson SH; Langevine CM; Dyckman AJ; Pattoli M; Burke JR; Yang X; Gillooly KM; McIntyre KW; Chen L; Dodd JH; McKinnon M; Barrish JC; Pitts WJ
    Bioorg Med Chem Lett; 2009 May; 19(10):2646-9. PubMed ID: 19376699
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors.
    Belema M; Bunker A; Nguyen VN; Beaulieu F; Ouellet C; Qiu Y; Zhang Y; Martel A; Burke JR; McIntyre KW; Pattoli MA; Daloisio C; Gillooly KM; Clarke WJ; Brassil PJ; Zusi FC; Vyas DM
    Bioorg Med Chem Lett; 2007 Aug; 17(15):4284-9. PubMed ID: 17540562
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-kappaB and p38.
    Hiramitsu T; Yasuda T; Ito H; Shimizu M; Julovi SM; Kakinuma T; Akiyoshi M; Yoshida M; Nakamura T
    Rheumatology (Oxford); 2006 Jul; 45(7):824-32. PubMed ID: 16449361
    [TBL] [Abstract][Full Text] [Related]  

  • 31. IKKbeta inhibitors identification part I: homology model assisted structure based virtual screening.
    Nagarajan S; Doddareddy Mr; Choo H; Cho YS; Oh KS; Lee BH; Pae AN
    Bioorg Med Chem; 2009 Apr; 17(7):2759-66. PubMed ID: 19285872
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3.
    Patch RJ; Baumann CA; Liu J; Gibbs AC; Ott H; Lattanze J; Player MR
    Bioorg Med Chem Lett; 2006 Jun; 16(12):3282-6. PubMed ID: 16580199
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes.
    Xu H; He Y; Yang X; Liang L; Zhan Z; Ye Y; Yang X; Lian F; Sun L
    Rheumatology (Oxford); 2007 Jun; 46(6):920-6. PubMed ID: 17314215
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms.
    Thiel MJ; Schaefer CJ; Lesch ME; Mobley JL; Dudley DT; Tecle H; Barrett SD; Schrier DJ; Flory CM
    Arthritis Rheum; 2007 Oct; 56(10):3347-57. PubMed ID: 17907188
    [TBL] [Abstract][Full Text] [Related]  

  • 35. The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases.
    Christopher JA; Avitabile BG; Bamborough P; Champigny AC; Cutler GJ; Dyos SL; Grace KG; Kerns JK; Kitson JD; Mellor GW; Morey JV; Morse MA; O'Malley CF; Patel CB; Probst N; Rumsey W; Smith CA; Wilson MJ
    Bioorg Med Chem Lett; 2007 Jul; 17(14):3972-7. PubMed ID: 17502144
    [TBL] [Abstract][Full Text] [Related]  

  • 36. 'Reverse' alpha-ketoamide-based p38 MAP kinase inhibitors.
    Montalban AG; Boman E; Chang CD; Ceide SC; Dahl R; Dalesandro D; Delaet NG; Erb E; Gibbs A; Kahl J; Kessler L; Lundström J; Miller S; Nakanishi H; Roberts E; Saiah E; Sullivan R; Wang Z; Larson CJ
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5456-9. PubMed ID: 18835164
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
    DiMauro EF; Newcomb J; Nunes JJ; Bemis JE; Boucher C; Chai L; Chaffee SC; Deak HL; Epstein LF; Faust T; Gallant P; Gore A; Gu Y; Henkle B; Hsieh F; Huang X; Kim JL; Lee JH; Martin MW; McGowan DC; Metz D; Mohn D; Morgenstern KA; Oliveira-dos-Santos A; Patel VF; Powers D; Rose PE; Schneider S; Tomlinson SA; Tudor YY; Turci SM; Welcher AA; Zhao H; Zhu L; Zhu X
    J Med Chem; 2008 Mar; 51(6):1681-94. PubMed ID: 18321037
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-kappaB- and p38 MAPK-dependent signalling pathways.
    Kim HR; Cho ML; Kim KW; Juhn JY; Hwang SY; Yoon CH; Park SH; Lee SH; Kim HY
    Rheumatology (Oxford); 2007 Jan; 46(1):57-64. PubMed ID: 16772307
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Effect of nuclear factor-kappaB inhibition on rheumatoid fibroblast-like synoviocytes and collagen induced arthritis.
    Okazaki Y; Sawada T; Nagatani K; Komagata Y; Inoue T; Muto S; Itai A; Yamamoto K
    J Rheumatol; 2005 Aug; 32(8):1440-7. PubMed ID: 16078317
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Anti-interleukin-1 and anti-CD44 interventions producing significant inhibition of cartilage destruction in an in vitro model of cartilage invasion by rheumatoid arthritis synovial fibroblasts.
    Neidhart M; Gay RE; Gay S
    Arthritis Rheum; 2000 Aug; 43(8):1719-28. PubMed ID: 10943861
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 4.