These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

240 related articles for article (PubMed ID: 19926793)

  • 1. beta-Secretase inhibitor potency is decreased by aberrant beta-cleavage location of the "Swedish mutant" amyloid precursor protein.
    Yamakawa H; Yagishita S; Futai E; Ishiura S
    J Biol Chem; 2010 Jan; 285(3):1634-42. PubMed ID: 19926793
    [TBL] [Abstract][Full Text] [Related]  

  • 2. NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.
    Buggia-Prevot V; Sevalle J; Rossner S; Checler F
    J Biol Chem; 2008 Apr; 283(15):10037-47. PubMed ID: 18263584
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
    Li S; Hou H; Mori T; Sawmiller D; Smith A; Tian J; Wang Y; Giunta B; Sanberg PR; Zhang S; Tan J
    Sci Rep; 2015 Jun; 5():11322. PubMed ID: 26091071
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
    Kimura A; Hata S; Suzuki T
    J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The Swedish dilemma - the almost exclusive use of APPswe-based mouse models impedes adequate evaluation of alternative β-secretases.
    Armbrust F; Bickenbach K; Marengo L; Pietrzik C; Becker-Pauly C
    Biochim Biophys Acta Mol Cell Res; 2022 Mar; 1869(3):119164. PubMed ID: 34699873
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
    Thinakaran G; Teplow DB; Siman R; Greenberg B; Sisodia SS
    J Biol Chem; 1996 Apr; 271(16):9390-7. PubMed ID: 8621605
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
    Pinnix I; Ghiso JA; Pappolla MA; Sambamurti K
    Am J Geriatr Psychiatry; 2013 May; 21(5):474-83. PubMed ID: 23570890
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.
    Griffiths HH; Whitehouse IJ; Baybutt H; Brown D; Kellett KA; Jackson CD; Turner AJ; Piccardo P; Manson JC; Hooper NM
    J Biol Chem; 2011 Sep; 286(38):33489-500. PubMed ID: 21795680
    [TBL] [Abstract][Full Text] [Related]  

  • 10. η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
    Willem M; Tahirovic S; Busche MA; Ovsepian SV; Chafai M; Kootar S; Hornburg D; Evans LD; Moore S; Daria A; Hampel H; Müller V; Giudici C; Nuscher B; Wenninger-Weinzierl A; Kremmer E; Heneka MT; Thal DR; Giedraitis V; Lannfelt L; Müller U; Livesey FJ; Meissner F; Herms J; Konnerth A; Marie H; Haass C
    Nature; 2015 Oct; 526(7573):443-7. PubMed ID: 26322584
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Spatial-Temporal Mapping Reveals the Golgi as the Major Processing Site for the Pathogenic Swedish APP Mutation: Familial APP Mutant Shifts the Major APP Processing Site.
    Wang J; Gleeson PA; Fourriere L
    Traffic; 2024 Mar; 25(3):e12932. PubMed ID: 38528836
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.
    Colombo A; Wang H; Kuhn PH; Page R; Kremmer E; Dempsey PJ; Crawford HC; Lichtenthaler SF
    Neurobiol Dis; 2013 Jan; 49():137-47. PubMed ID: 22940630
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.
    Vetrivel KS; Barman A; Chen Y; Nguyen PD; Wagner SL; Prabhakar R; Thinakaran G
    J Biol Chem; 2011 Jul; 286(29):26166-77. PubMed ID: 21642424
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
    Sinha S; Anderson JP; Barbour R; Basi GS; Caccavello R; Davis D; Doan M; Dovey HF; Frigon N; Hong J; Jacobson-Croak K; Jewett N; Keim P; Knops J; Lieberburg I; Power M; Tan H; Tatsuno G; Tung J; Schenk D; Seubert P; Suomensaari SM; Wang S; Walker D; Zhao J; McConlogue L; John V
    Nature; 1999 Dec; 402(6761):537-40. PubMed ID: 10591214
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Camelid heavy chain only antibody fragment domain against β-site of amyloid precursor protein cleaving enzyme 1 inhibits β-secretase activity in vitro and in vivo.
    Dorresteijn B; Rotman M; Faber D; Schravesande R; Suidgeest E; van der Weerd L; van der Maarel SM; Verrips CT; El Khattabi M
    FEBS J; 2015 Sep; 282(18):3618-31. PubMed ID: 26147692
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein.
    Mamada N; Tanokashira D; Ishii K; Tamaoka A; Araki W
    Biochem Biophys Res Commun; 2017 Apr; 486(2):321-328. PubMed ID: 28302486
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase.
    Steinhilb ML; Turner RS; Gaut JR
    J Biol Chem; 2001 Feb; 276(6):4476-84. PubMed ID: 11084038
    [TBL] [Abstract][Full Text] [Related]  

  • 18. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S; Price EA; Wu G; Crouthamel MC; Shi XP; Tugusheva K; Tyler KX; Kahana J; Ellis J; Jin L; Steele T; Stachel S; Coburn C; Simon AJ
    J Pharmacol Exp Ther; 2008 Mar; 324(3):957-69. PubMed ID: 18156464
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.
    Shi XP; Tugusheva K; Bruce JE; Lucka A; Chen-Dodson E; Hu B; Wu GX; Price E; Register RB; Lineberger J; Miller R; Tang MJ; Espeseth A; Kahana J; Wolfe A; Crouthamel MC; Sankaranarayanan S; Simon A; Chen L; Lai MT; Pietrak B; DiMuzio J; Li Y; Xu M; Huang Q; Garsky V; Sardana MK; Hazuda DJ
    J Alzheimers Dis; 2005 Apr; 7(2):139-48; discussion 173-80. PubMed ID: 15851852
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
    J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.