BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 19941875)

  • 1. Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells.
    Kalapila AG; Pegg AE
    Mutat Res; 2010 Feb; 684(1-2):35-42. PubMed ID: 19941875
    [TBL] [Abstract][Full Text] [Related]  

  • 2. O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate.
    Liu L; Williams KM; Guengerich FP; Pegg AE
    Chem Res Toxicol; 2004 Jun; 17(6):742-52. PubMed ID: 15206895
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase.
    Valadez JG; Liu L; Loktionova NA; Pegg AE; Guengerich FP
    Chem Res Toxicol; 2004 Jul; 17(7):972-82. PubMed ID: 15257623
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins.
    Kalapila AG; Loktionova NA; Pegg AE
    Environ Mol Mutagen; 2009 Jul; 50(6):502-14. PubMed ID: 19472322
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice.
    Cho SH; Guengerich FP
    Chem Res Toxicol; 2013 Nov; 26(11):1765-74. PubMed ID: 24191644
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.
    Liu L; Watanabe K; Fang Q; Williams KM; Guengerich FP; Pegg AE
    Chem Res Toxicol; 2007 Jan; 20(1):155-63. PubMed ID: 17226938
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Strand-specific mutation induction by 1,2-dibromomethane at the hypoxanthine-guanine phosphoribosyltransferase locus of Chinese hamster ovary cells.
    Ballering LA; Vogel EW; Vrieling H; Nivard MJ
    Mutagenesis; 1998 Jan; 13(1):61-5. PubMed ID: 9491396
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Role of O6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity.
    Cai Y; Wu MH; Ludeman SM; Grdina DJ; Dolan ME
    Cancer Res; 1999 Jul; 59(13):3059-63. PubMed ID: 10397244
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
    Cai Y; Wu MH; Xu-Welliver M; Pegg AE; Ludeman SM; Dolan ME
    Cancer Res; 2000 Oct; 60(19):5464-9. PubMed ID: 11034089
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer.
    Liu L; Schwartz S; Davis BM; Gerson SL
    Cancer Res; 2002 Jun; 62(11):3070-6. PubMed ID: 12036916
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular characterization of mutations in the hprt gene of normal human skin keratinocytes treated with N-ethyl-N-nitrosourea: influence of O6-alkylguanine alkyltransferase.
    Tong HH; Park JH; Brady T; Weghorst CM; D'Ambrosio SM
    Environ Mol Mutagen; 1997; 29(2):168-79. PubMed ID: 9118969
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutations induced by 1,3-butadiene metabolites, butadiene diolepoxide, and 1,2,3,4-diepoxybutane at the Hprt locus in CHO-K1 cells.
    Lee DH; Kim TH; Lee SY; Kim HJ; Rhee SK; Yoon B; Pfeifer GP; Lee CS
    Mol Cells; 2002 Dec; 14(3):411-9. PubMed ID: 12521305
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations.
    Loecken EM; Guengerich FP
    Chem Res Toxicol; 2008 Feb; 21(2):453-8. PubMed ID: 18163542
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 1,3-butadiene: cancer, mutations, and adducts. Part II: Roles of two metabolites of 1,3-butadiene in mediating its in vivo genotoxicity.
    Recio L; Saranko CJ; Steen AM
    Res Rep Health Eff Inst; 2000 Mar; (92):49-87; discussion 141-9. PubMed ID: 10925839
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.
    Loktionova NA; Pegg AE
    Cancer Res; 1996 Apr; 56(7):1578-83. PubMed ID: 8603405
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts.
    Lukash LL; Boldt J; Pegg AE; Dolan ME; Maher VM; McCormick JJ
    Mutat Res; 1991; 250(1-2):397-409. PubMed ID: 1944354
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Human O(6)-alkylguanine-DNA alkyltransferase: protection against alkylating agents and sensitization to dibromoalkanes.
    Abril N; Luque-Romero FL; Christians FC; Encell LP; Loeb LA; Pueyo C
    Carcinogenesis; 1999 Nov; 20(11):2089-94. PubMed ID: 10545410
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced mutagenesis in recombinant systems.
    Loecken EM; Dasari S; Hill S; Tabb DL; Guengerich FP
    Chem Res Toxicol; 2009 Jun; 22(6):1069-76. PubMed ID: 19364102
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity.
    Baumann RP; Shyam K; Penketh PG; Remack JS; Brent TP; Sartorelli AC
    Cancer Chemother Pharmacol; 2004 Apr; 53(4):288-95. PubMed ID: 14685775
    [TBL] [Abstract][Full Text] [Related]  

  • 20. DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells.
    Tretyakova NY; Michaelson-Richie ED; Gherezghiher TB; Kurtz J; Ming X; Wickramaratne S; Campion M; Kanugula S; Pegg AE; Campbell C
    Biochemistry; 2013 May; 52(18):3171-81. PubMed ID: 23566219
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.