191 related articles for article (PubMed ID: 19944064)
1. Rational engineering of cytochromes P450 2B6 and 2B11 for enhanced stability: Insights into structural importance of residue 334.
Talakad JC; Wilderman PR; Davydov DR; Kumar S; Halpert JR
Arch Biochem Biophys; 2010 Feb; 494(2):151-8. PubMed ID: 19944064
[TBL] [Abstract][Full Text] [Related]
2. Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1, and 2B5.
John GH; Hasler JA; He YA; Halpert JR
Arch Biochem Biophys; 1994 Nov; 314(2):367-75. PubMed ID: 7979377
[TBL] [Abstract][Full Text] [Related]
3. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
Liu J; He YA; Halpert JR
Arch Biochem Biophys; 1996 Mar; 327(1):167-73. PubMed ID: 8615687
[TBL] [Abstract][Full Text] [Related]
4. Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11.
Harlow GR; He YA; Halpert JR
Biochim Biophys Acta; 1997 Apr; 1338(2):259-66. PubMed ID: 9128144
[TBL] [Abstract][Full Text] [Related]
5. Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
Hasler JA; Harlow GR; Szklarz GD; John GH; Kedzie KM; Burnett VL; He YA; Kaminsky LS; Halpert JR
Mol Pharmacol; 1994 Aug; 46(2):338-45. PubMed ID: 8078495
[TBL] [Abstract][Full Text] [Related]
6. 2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11.
Waller SC; He YA; Harlow GR; He YQ; Mash EA; Halpert JR
Chem Res Toxicol; 1999 Aug; 12(8):690-9. PubMed ID: 10458702
[TBL] [Abstract][Full Text] [Related]
7. Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase.
Harlow GR; Halpert JR
Arch Biochem Biophys; 1996 Feb; 326(1):85-92. PubMed ID: 8579377
[TBL] [Abstract][Full Text] [Related]
8. Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling.
Domanski TL; Schultz KM; Roussel F; Stevens JC; Halpert JR
J Pharmacol Exp Ther; 1999 Sep; 290(3):1141-7. PubMed ID: 10454488
[TBL] [Abstract][Full Text] [Related]
9. Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11.
Jounaidi Y; Chen CS; Veal GJ; Waxman DJ
Mol Cancer Ther; 2006 Mar; 5(3):541-55. PubMed ID: 16546968
[TBL] [Abstract][Full Text] [Related]
10. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
Szklarz GD; He YQ; Kedzie KM; Halpert JR; Burnett VL
Arch Biochem Biophys; 1996 Mar; 327(2):308-18. PubMed ID: 8619620
[TBL] [Abstract][Full Text] [Related]
11. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane.
Chun J; Kent UM; Moss RM; Sayre LM; Hollenberg PF
Drug Metab Dispos; 2000 Aug; 28(8):905-11. PubMed ID: 10901699
[TBL] [Abstract][Full Text] [Related]
12. Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.
Gay SC; Shah MB; Talakad JC; Maekawa K; Roberts AG; Wilderman PR; Sun L; Yang JY; Huelga SC; Hong WX; Zhang Q; Stout CD; Halpert JR
Mol Pharmacol; 2010 Apr; 77(4):529-38. PubMed ID: 20061448
[TBL] [Abstract][Full Text] [Related]
13. Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.
Iwasaki M; Lindberg RL; Juvonen RO; Negishi M
Biochem J; 1993 Apr; 291 ( Pt 2)(Pt 2):569-73. PubMed ID: 8484736
[TBL] [Abstract][Full Text] [Related]
14. Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.
He YQ; Harlow GR; Szklarz GD; Halpert JR
Arch Biochem Biophys; 1998 Feb; 350(2):333-9. PubMed ID: 9473309
[TBL] [Abstract][Full Text] [Related]
15. Construction of a 3D model of cytochrome P450 2B4.
Chang YT; Stiffelman OB; Vakser IA; Loew GH; Bridges A; Waskell L
Protein Eng; 1997 Feb; 10(2):119-29. PubMed ID: 9089811
[TBL] [Abstract][Full Text] [Related]
16. Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.
Kumar S; Zhao Y; Sun L; Negi SS; Halpert JR; Muralidhara BK
Mol Pharmacol; 2007 Nov; 72(5):1191-9. PubMed ID: 17715394
[TBL] [Abstract][Full Text] [Related]
17. Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4.
Talakad JC; Shah MB; Walker GS; Xiang C; Halpert JR; Dalvie D
Drug Metab Dispos; 2011 Mar; 39(3):539-50. PubMed ID: 21156812
[TBL] [Abstract][Full Text] [Related]
18. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
Luo Z; He YA; Halpert JR
Arch Biochem Biophys; 1994 Feb; 309(1):52-7. PubMed ID: 8117113
[TBL] [Abstract][Full Text] [Related]
19. Purification from liver microsomes from untreated cynomolgus monkeys of cytochrome P450 closely related to human cytochrome P450 2B6.
Ohmori S; Shirakawa C; Motohashi K; Yoshida H; Abe H; Nakamura T; Horie T; Kitagawa H; Asaoka K; Rikihisa T
Mol Pharmacol; 1993 Feb; 43(2):183-90. PubMed ID: 8429823
[TBL] [Abstract][Full Text] [Related]
20. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.
Liu J; Shah MB; Zhang Q; Stout CD; Halpert JR; Wilderman PR
Biochemistry; 2016 Apr; 55(13):1997-2007. PubMed ID: 26982502
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
