195 related articles for article (PubMed ID: 19947601)
1. Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.
Kamenecka T; Jiang R; Song X; Duckett D; Chen W; Ling YY; Habel J; Laughlin JD; Chambers J; Figuera-Losada M; Cameron MD; Lin L; Ruiz CH; LoGrasso PV
J Med Chem; 2010 Jan; 53(1):419-31. PubMed ID: 19947601
[TBL] [Abstract][Full Text] [Related]
2. Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.
Palmer WS; Alam M; Arzeno HB; Chang KC; Dunn JP; Goldstein DM; Gong L; Goyal B; Hermann JC; Hogg JH; Hsieh G; Jahangir A; Janson C; Jin S; Ursula Kammlott R; Kuglstatter A; Lukacs C; Michoud C; Niu L; Reuter DC; Shao A; Silva T; Trejo-Martin TA; Stein K; Tan YC; Tivitmahaisoon P; Tran P; Wagner P; Weller P; Wu SY
Bioorg Med Chem Lett; 2013 Mar; 23(5):1486-92. PubMed ID: 23352510
[TBL] [Abstract][Full Text] [Related]
3. Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.
Gong L; Han X; Silva T; Tan YC; Goyal B; Tivitmahaisoon P; Trejo A; Palmer W; Hogg H; Jahagir A; Alam M; Wagner P; Stein K; Filonova L; Loe B; Makra F; Rotstein D; Rapatova L; Dunn J; Zuo F; Dal Porto J; Wong B; Jin S; Chang A; Tran P; Hsieh G; Niu L; Shao A; Reuter D; Hermann J; Kuglstatter A; Goldstein D
Bioorg Med Chem Lett; 2013 Jun; 23(12):3565-9. PubMed ID: 23664880
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.
Humphries PS; Lafontaine JA; Agree CS; Alexander D; Chen P; Do QQ; Li LY; Lunney EA; Rajapakse RJ; Siegel K; Timofeevski SL; Wang T; Wilhite DM
Bioorg Med Chem Lett; 2009 Apr; 19(8):2099-102. PubMed ID: 19327989
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors.
Song X; Chen W; Lin L; Ruiz CH; Cameron MD; Duckett DR; Kamenecka TM
Bioorg Med Chem Lett; 2011 Dec; 21(23):7072-5. PubMed ID: 22004719
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors.
Noël R; Shin Y; Song X; He Y; Koenig M; Chen W; Ling YY; Lin L; Ruiz CH; LoGrasso P; Cameron MD; Duckett DR; Kamenecka TM
Bioorg Med Chem Lett; 2011 May; 21(9):2732-5. PubMed ID: 21185177
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors.
He Y; Kamenecka TM; Shin Y; Song X; Jiang R; Noel R; Duckett D; Chen W; Ling YY; Cameron MD; Lin L; Khan S; Koenig M; LoGrasso PV
Bioorg Med Chem Lett; 2011 Mar; 21(6):1719-23. PubMed ID: 21316221
[TBL] [Abstract][Full Text] [Related]
8. Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.
Liu M; Wang S; Clampit JE; Gum RJ; Haasch DL; Rondinone CM; Trevillyan JM; Abad-Zapatero C; Fry EH; Sham HL; Liu G
Bioorg Med Chem Lett; 2007 Feb; 17(3):668-72. PubMed ID: 17107797
[TBL] [Abstract][Full Text] [Related]
9. Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
DiMauro EF; Newcomb J; Nunes JJ; Bemis JE; Boucher C; Chai L; Chaffee SC; Deak HL; Epstein LF; Faust T; Gallant P; Gore A; Gu Y; Henkle B; Hsieh F; Huang X; Kim JL; Lee JH; Martin MW; McGowan DC; Metz D; Mohn D; Morgenstern KA; Oliveira-dos-Santos A; Patel VF; Powers D; Rose PE; Schneider S; Tomlinson SA; Tudor YY; Turci SM; Welcher AA; Zhao H; Zhu L; Zhu X
J Med Chem; 2008 Mar; 51(6):1681-94. PubMed ID: 18321037
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors.
He Y; Duckett D; Chen W; Ling YY; Cameron MD; Lin L; Ruiz CH; Lograsso PV; Kamenecka TM; Koenig M
Bioorg Med Chem Lett; 2014 Jan; 24(1):161-4. PubMed ID: 24332487
[TBL] [Abstract][Full Text] [Related]
11. Discovery of a novel series of 4-quinolone JNK inhibitors.
Gong L; Tan YC; Boice G; Abbot S; McCaleb K; Iyer P; Zuo F; Dal Porto J; Wong B; Jin S; Chang A; Tran P; Hsieh G; Niu L; Shao A; Reuter D; Lukacs CM; Ursula Kammlott R; Kuglstatter A; Goldstein D
Bioorg Med Chem Lett; 2012 Dec; 22(24):7381-7. PubMed ID: 23142618
[TBL] [Abstract][Full Text] [Related]
12. Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors.
Das J; Moquin RV; Pitt S; Zhang R; Shen DR; McIntyre KW; Gillooly K; Doweyko AM; Sack JS; Zhang H; Kiefer SE; Kish K; McKinnon M; Barrish JC; Dodd JH; Schieven GL; Leftheris K
Bioorg Med Chem Lett; 2008 Apr; 18(8):2652-7. PubMed ID: 18359226
[TBL] [Abstract][Full Text] [Related]
13. Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.
Wolle P; Hardick J; Cronin SJF; Engel J; Baumann M; Lategahn J; Penninger JM; Rauh D
J Med Chem; 2019 Mar; 62(5):2843-2848. PubMed ID: 30768270
[TBL] [Abstract][Full Text] [Related]
14. Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Bowers S; Truong AP; Jeffrey Neitz R; Hom RK; Sealy JM; Probst GD; Quincy D; Peterson B; Chan W; Galemmo RA; Konradi AW; Sham HL; Tóth G; Pan H; Lin M; Yao N; Artis DR; Zhang H; Chen L; Dryer M; Samant B; Zmolek W; Wong K; Lorentzen C; Goldbach E; Tonn G; Quinn KP; Sauer JM; Wright S; Powell K; Ruslim L; Ren Z; Bard F; Yednock TA; Griswold-Prenner I
Bioorg Med Chem Lett; 2011 Sep; 21(18):5521-7. PubMed ID: 21813278
[TBL] [Abstract][Full Text] [Related]
15. Inhibitors of c-jun-N-terminal kinase (JNK).
LoGrasso P; Kamenecka T
Mini Rev Med Chem; 2008 Jul; 8(8):755-66. PubMed ID: 18673131
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors.
De SK; Chen V; Stebbins JL; Chen LH; Cellitti JF; Machleidt T; Barile E; Riel-Mehan M; Dahl R; Yang L; Emdadi A; Murphy R; Pellecchia M
Bioorg Med Chem; 2010 Jan; 18(2):590-6. PubMed ID: 20045647
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors.
Shin Y; Chen W; Habel J; Duckett D; Ling YY; Koenig M; He Y; Vojkovsky T; LoGrasso P; Kamenecka TM
Bioorg Med Chem Lett; 2009 Jun; 19(12):3344-7. PubMed ID: 19433357
[TBL] [Abstract][Full Text] [Related]
18. Discovery of the c-Jun N-Terminal Kinase Inhibitor
Nagy MA; Hilgraf R; Mortensen DS; Elsner J; Norris S; Tikhe J; Yoon W; Paisner D; Delgado M; Erdman P; Haelewyn J; Khambatta G; Xu L; Romanow WJ; Condroski K; Bahmanyar S; McCarrick M; Benish B; Blease K; LeBrun L; Moghaddam MF; Apuy J; Canan SS; Bennett BL; Satoh Y
J Med Chem; 2021 Dec; 64(24):18193-18208. PubMed ID: 34894681
[TBL] [Abstract][Full Text] [Related]
19. Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Hom RK; Bowers S; Sealy JM; Truong AP; Probst GD; Neitzel ML; Neitz RJ; Fang L; Brogley L; Wu J; Konradi AW; Sham HL; Tóth G; Pan H; Yao N; Artis DR; Quinn K; Sauer JM; Powell K; Ren Z; Bard F; Yednock TA; Griswold-Prenner I
Bioorg Med Chem Lett; 2010 Dec; 20(24):7303-7. PubMed ID: 21071223
[TBL] [Abstract][Full Text] [Related]
20. Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors.
Choi JS; Hwang HJ; Kim SW; Lee BI; Lee J; Song HJ; Koh JS; Kim JH; Lee PH
Bioorg Med Chem Lett; 2015 Oct; 25(20):4441-6. PubMed ID: 26384287
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
