245 related articles for article (PubMed ID: 19952282)
1. Trypanothione efficiently intercepts nitric oxide as a harmless iron complex in trypanosomatid parasites.
Bocedi A; Dawood KF; Fabrini R; Federici G; Gradoni L; Pedersen JZ; Ricci G
FASEB J; 2010 Apr; 24(4):1035-42. PubMed ID: 19952282
[TBL] [Abstract][Full Text] [Related]
2. The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
Krauth-Siegel RL; Meiering SK; Schmidt H
Biol Chem; 2003 Apr; 384(4):539-49. PubMed ID: 12751784
[TBL] [Abstract][Full Text] [Related]
3. Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei.
Zimmermann S; Oufir M; Leroux A; Krauth-Siegel RL; Becker K; Kaiser M; Brun R; Hamburger M; Adams M
Bioorg Med Chem; 2013 Nov; 21(22):7202-9. PubMed ID: 24080104
[TBL] [Abstract][Full Text] [Related]
4. Polyamine metabolism in Leishmania: from arginine to trypanothione.
Colotti G; Ilari A
Amino Acids; 2011 Feb; 40(2):269-85. PubMed ID: 20512387
[TBL] [Abstract][Full Text] [Related]
5. Glutathione transferases sequester toxic dinitrosyl-iron complexes in cells. A protection mechanism against excess nitric oxide.
Pedersen JZ; De Maria F; Turella P; Federici G; Mattei M; Fabrini R; Dawood KF; Massimi M; Caccuri AM; Ricci G
J Biol Chem; 2007 Mar; 282(9):6364-71. PubMed ID: 17197702
[TBL] [Abstract][Full Text] [Related]
6. Targeting Trypanothione Metabolism in Trypanosomatids.
González-Montero MC; Andrés-Rodríguez J; García-Fernández N; Pérez-Pertejo Y; Reguera RM; Balaña-Fouce R; García-Estrada C
Molecules; 2024 May; 29(10):. PubMed ID: 38792079
[TBL] [Abstract][Full Text] [Related]
7. Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes.
Wendler A; Irsch T; Rabbani N; Thornalley PJ; Krauth-Siegel RL
Mol Biochem Parasitol; 2009 Jan; 163(1):19-27. PubMed ID: 18848584
[TBL] [Abstract][Full Text] [Related]
8. Validation of Trypanosoma brucei trypanothione synthetase as drug target.
Comini MA; Guerrero SA; Haile S; Menge U; Lünsdorf H; Flohé L
Free Radic Biol Med; 2004 May; 36(10):1289-302. PubMed ID: 15110394
[TBL] [Abstract][Full Text] [Related]
9. Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
Dormeyer M; Reckenfelderbäumer N; Ludemann H; Krauth-Siegel RL
J Biol Chem; 2001 Apr; 276(14):10602-6. PubMed ID: 11150302
[TBL] [Abstract][Full Text] [Related]
10. Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Heby O; Persson L; Rentala M
Amino Acids; 2007 Aug; 33(2):359-66. PubMed ID: 17610127
[TBL] [Abstract][Full Text] [Related]
11. Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Stoll VS; Simpson SJ; Krauth-Siegel RL; Walsh CT; Pai EF
Biochemistry; 1997 May; 36(21):6437-47. PubMed ID: 9174360
[TBL] [Abstract][Full Text] [Related]
12. Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification.
Irigoín F; Cibils L; Comini MA; Wilkinson SR; Flohé L; Radi R
Free Radic Biol Med; 2008 Sep; 45(6):733-42. PubMed ID: 18588970
[TBL] [Abstract][Full Text] [Related]
13. Trypanothione biosynthesis in Leishmania major.
Oza SL; Shaw MP; Wyllie S; Fairlamb AH
Mol Biochem Parasitol; 2005 Jan; 139(1):107-16. PubMed ID: 15610825
[TBL] [Abstract][Full Text] [Related]
14. Cloning and expression of trypanothione reductase from a New World Leishmania species.
Castro-Pinto DB; Genestra M; Menezes GB; Waghabi M; Gonçalves A; De Nigris Del Cistia C; Sant'Anna CM; Leon LL; Mendonça-Lima L
Arch Microbiol; 2008 Apr; 189(4):375-84. PubMed ID: 18060667
[TBL] [Abstract][Full Text] [Related]
15. Drug target validation of the trypanothione pathway enzymes through metabolic modelling.
Olin-Sandoval V; González-Chávez Z; Berzunza-Cruz M; Martínez I; Jasso-Chávez R; Becker I; Espinoza B; Moreno-Sánchez R; Saavedra E
FEBS J; 2012 May; 279(10):1811-33. PubMed ID: 22394478
[TBL] [Abstract][Full Text] [Related]
16. Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development.
Schmidt A; Krauth-Siegel RL
Curr Top Med Chem; 2002 Nov; 2(11):1239-59. PubMed ID: 12171583
[TBL] [Abstract][Full Text] [Related]
17. Stress-Induced Protein S-Glutathionylation and S-Trypanothionylation in African Trypanosomes-A Quantitative Redox Proteome and Thiol Analysis.
Ulrich K; Finkenzeller C; Merker S; Rojas F; Matthews K; Ruppert T; Krauth-Siegel RL
Antioxid Redox Signal; 2017 Sep; 27(9):517-533. PubMed ID: 28338335
[TBL] [Abstract][Full Text] [Related]
18. The dithiol glutaredoxins of african trypanosomes have distinct roles and are closely linked to the unique trypanothione metabolism.
Ceylan S; Seidel V; Ziebart N; Berndt C; Dirdjaja N; Krauth-Siegel RL
J Biol Chem; 2010 Nov; 285(45):35224-37. PubMed ID: 20826822
[TBL] [Abstract][Full Text] [Related]
19. Molecular studies on trypanothione reductase: an antiparasitic target enzyme.
Walsh C; Bradley M; Nadeau K
Curr Top Cell Regul; 1992; 33():409-17. PubMed ID: 1354149
[No Abstract] [Full Text] [Related]
20. Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism.
Colotti G; Saccoliti F; Gramiccia M; Di Muccio T; Prakash J; Yadav S; Dubey VK; Vistoli G; Battista T; Mocci S; Fiorillo A; Bibi A; Madia VN; Messore A; Costi R; Di Santo R; Ilari A
Amino Acids; 2020 Feb; 52(2):247-259. PubMed ID: 31037461
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]