233 related articles for article (PubMed ID: 19954435)
1. Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone.
Roman G; Rahman MN; Vukomanovic D; Jia Z; Nakatsu K; Szarek WA
Chem Biol Drug Des; 2010 Jan; 75(1):68-90. PubMed ID: 19954435
[TBL] [Abstract][Full Text] [Related]
2. Heme oxygenase inhibition by 1-aryl-2-(1h-imidazol-1-yl/1h-1,2,4-triazol-1-yl)ethanones and their derivatives.
Roman G; Vlahakis JZ; Vukomanovic D; Nakatsu K; Szarek WA
ChemMedChem; 2010 Sep; 5(9):1541-55. PubMed ID: 20652928
[TBL] [Abstract][Full Text] [Related]
3. Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring.
Roman G; Riley JG; Vlahakis JZ; Kinobe RT; Brien JF; Nakatsu K; Szarek WA
Bioorg Med Chem; 2007 May; 15(9):3225-34. PubMed ID: 17339115
[TBL] [Abstract][Full Text] [Related]
4. X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors.
Rahman MN; Vlahakis JZ; Szarek WA; Nakatsu K; Jia Z
J Med Chem; 2008 Oct; 51(19):5943-52. PubMed ID: 18798608
[TBL] [Abstract][Full Text] [Related]
5. X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase.
Sugishima M; Higashimoto Y; Oishi T; Takahashi H; Sakamoto H; Noguchi M; Fukuyama K
Biochemistry; 2007 Feb; 46(7):1860-7. PubMed ID: 17253780
[TBL] [Abstract][Full Text] [Related]
6. X-ray crystal structure of human heme oxygenase-1 with (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: a novel, inducible binding mode.
Rahman MN; Vlahakis JZ; Vukomanovic D; Szarek WA; Nakatsu K; Jia Z
J Med Chem; 2009 Aug; 52(15):4946-50. PubMed ID: 19601578
[TBL] [Abstract][Full Text] [Related]
7. Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties.
Salerno L; Pittalà V; Romeo G; Modica MN; Siracusa MA; Di Giacomo C; Acquaviva R; Barbagallo I; Tibullo D; Sorrenti V
Bioorg Med Chem; 2013 Sep; 21(17):5145-53. PubMed ID: 23867390
[TBL] [Abstract][Full Text] [Related]
8. Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.
Vlahakis JZ; Kinobe RT; Bowers RJ; Brien JF; Nakatsu K; Szarek WA
J Med Chem; 2006 Jul; 49(14):4437-41. PubMed ID: 16821802
[TBL] [Abstract][Full Text] [Related]
9. Recombinant truncated and microsomal heme oxygenase-1 and -2: differential sensitivity to inhibitors.
Vukomanovic D; McLaughlin B; Rahman MN; Vlahakis JZ; Roman G; Dercho RA; Kinobe RT; Hum M; Brien JF; Jia Z; Szarek WA; Nakatsu K
Can J Physiol Pharmacol; 2010 Apr; 88(4):480-6. PubMed ID: 20555417
[TBL] [Abstract][Full Text] [Related]
10. Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors.
Rahman MN; Vlahakis JZ; Roman G; Vukomanovic D; Szarek WA; Nakatsu K; Jia Z
J Inorg Biochem; 2010 Mar; 104(3):324-30. PubMed ID: 19917515
[TBL] [Abstract][Full Text] [Related]
11. How does binding of imidazole-based inhibitors to heme oxygenase-1 influence their conformation? Insights combining crystal structures and molecular modelling.
Carletta A; Tilborg A; Moineaux L; de Ruyck J; Basile L; Salerno L; Romeo G; Wouters J; Guccione S
Acta Crystallogr B Struct Sci Cryst Eng Mater; 2015 Aug; 71(Pt 4):447-54. PubMed ID: 26208625
[TBL] [Abstract][Full Text] [Related]
12. Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.
Salerno L; Pittalà V; Romeo G; Modica MN; Marrazzo A; Siracusa MA; Sorrenti V; Di Giacomo C; Vanella L; Parayath NN; Greish K
Eur J Med Chem; 2015; 96():162-72. PubMed ID: 25874340
[TBL] [Abstract][Full Text] [Related]
13. Structure-Activity Relationships of 1,2-Disubstituted Benzimidazoles: Selective Inhibition of Heme Oxygenase-2 Activity.
Kong X; Vukomanovic D; Nakatsu K; Szarek WA
ChemMedChem; 2015 Aug; 10(8):1435-41. PubMed ID: 26083133
[TBL] [Abstract][Full Text] [Related]
14. Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme.
Sugishima M; Migita CT; Zhang X; Yoshida T; Fukuyama K
Eur J Biochem; 2004 Nov; 271(22):4517-25. PubMed ID: 15560792
[TBL] [Abstract][Full Text] [Related]
15. A novel, "double-clamp" binding mode for human heme oxygenase-1 inhibition.
Rahman MN; Vlahakis JZ; Vukomanovic D; Lee W; Szarek WA; Nakatsu K; Jia Z
PLoS One; 2012; 7(1):e29514. PubMed ID: 22276118
[TBL] [Abstract][Full Text] [Related]
16. Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position.
Vlahakis JZ; Vukomanovic D; Nakatsu K; Szarek WA
Bioorg Med Chem; 2013 Nov; 21(21):6788-95. PubMed ID: 24021581
[TBL] [Abstract][Full Text] [Related]
17. A comparative study of 1-substituted imidazole and 1,2,4-triazole antifungal compounds as inhibitors of testosterone hydroxylations catalysed by mouse hepatic microsomal cytochromes P-450.
Ballard SA; Lodola A; Tarbit MH
Biochem Pharmacol; 1988 Dec; 37(24):4643-51. PubMed ID: 3202901
[TBL] [Abstract][Full Text] [Related]
18. Chromatograpic resolution of phenylethanolic-azole racemic compounds highlighted stereoselective inhibition of heme oxygenase-1 by (R)-enantiomers.
Floresta G; Carotti A; Ianni F; Sorrenti V; Intagliata S; Rescifina A; Salerno L; Di Michele A; Sardella R; Pittalà V
Bioorg Chem; 2020 Jun; 99():103777. PubMed ID: 32222619
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring.
Vlahakis JZ; Hum M; Rahman MN; Jia Z; Nakatsu K; Szarek WA
Bioorg Med Chem; 2009 Mar; 17(6):2461-75. PubMed ID: 19268600
[TBL] [Abstract][Full Text] [Related]
20. 1H NMR characterization of the solution active site structure of substrate-bound, cyanide-inhibited heme oxygenase from Neisseria meningitidis: comparison to crystal structures.
Liu Y; Zhang X; Yoshida T; La Mar GN
Biochemistry; 2004 Aug; 43(31):10112-26. PubMed ID: 15287739
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]