BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 19956642)

  • 1. A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C.
    Basak A; Khatib AM; Mohottalage D; Basak S; Kolajova M; Bag SS; Basak A
    PLoS One; 2009 Nov; 4(11):e7700. PubMed ID: 19956642
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Modulating furin activity with designed mini-PDX peptides: synthesis and in vitro kinetic evaluation.
    Basak A; Lotfipour F
    FEBS Lett; 2005 Aug; 579(21):4813-21. PubMed ID: 16102752
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Enediynyl peptides and iso-coumarinyl methyl sulfones as inhibitors of proprotein convertases PCSK8/SKI-1/S1P and PCSK4/PC4: Design, synthesis and biological evaluations.
    Basak A; Goswami M; Rajkumar A; Mitra T; Majumdar S; O'Reilly P; Bdour HM; Trudeau VL; Basak A
    Bioorg Med Chem Lett; 2015; 25(10):2225-37. PubMed ID: 25881830
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases.
    Siegfried G; Basak A; Prichett-Pejic W; Scamuffa N; Ma L; Benjannet S; Veinot JP; Calvo F; Seidah N; Khatib AM
    Oncogene; 2005 Oct; 24(46):6925-35. PubMed ID: 16007151
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.
    Siegfried G; Basak A; Cromlish JA; Benjannet S; Marcinkiewicz J; Chrétien M; Seidah NG; Khatib AM
    J Clin Invest; 2003 Jun; 111(11):1723-32. PubMed ID: 12782675
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain.
    Basak A; Chen A; Scamuffa N; Mohottalage D; Basak S; Khatib AM
    Curr Med Chem; 2010; 17(21):2214-21. PubMed ID: 20459383
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration.
    Khatib AM; Lahlil R; Scamuffa N; Akimenko MA; Ernest S; Lomri A; Lalou C; Seidah NG; Villoutreix BO; Calvo F; Siegfried G
    PLoS One; 2010 Jul; 5(7):e11438. PubMed ID: 20625388
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1.
    Basak A; Ernst B; Brewer D; Seidah NG; Munzer JS; Lazure C; Lajoie GA
    J Pept Res; 1997 Jun; 49(6):596-603. PubMed ID: 9266488
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Proprotein convertase inhibitory activities of flavonoids isolated from Oroxylum indicum.
    Majumdar S; Mohanta BC; Chowdhury DR; Banik R; Dinda B; Basak A
    Curr Med Chem; 2010; 17(19):2049-58. PubMed ID: 20423311
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Template-assisted rational design of peptide inhibitors of furin using the lysine fragment of the mung bean trypsin inhibitor.
    Tao H; Zhang Z; Shi J; Shao XX; Cui D; Chi CW
    FEBS J; 2006 Sep; 273(17):3907-14. PubMed ID: 16934032
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.
    Becker GL; Lu Y; Hardes K; Strehlow B; Levesque C; Lindberg I; Sandvig K; Bakowsky U; Day R; Garten W; Steinmetzer T
    J Biol Chem; 2012 Jun; 287(26):21992-2003. PubMed ID: 22539349
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Limitations of inhibitory activities of polyphenols on furin-mediated substrate processing.
    Zhu J; Declercq J; Creemers JW; Chen C; Cui Y; Van de Ven WJ; Vermorken AJ
    Curr Med Chem; 2012; 19(21):3641-50. PubMed ID: 22716122
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.
    Jaaks P; D'Alessandro V; Grob N; Büel S; Hajdin K; Schäfer BW; Bernasconi M
    PLoS One; 2016; 11(8):e0161396. PubMed ID: 27548722
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design of peptide inhibitors for furin based on the C-terminal fragment of histone H1.2.
    Wang S; Han J; Wang Y; Lu W; Chi C
    Acta Biochim Biophys Sin (Shanghai); 2008 Oct; 40(10):848-54. PubMed ID: 18850049
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors.
    Tian S; Jianhua W
    Int J Biol Sci; 2010 Feb; 6(1):89-95. PubMed ID: 20151049
    [TBL] [Abstract][Full Text] [Related]  

  • 16. X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
    Dahms SO; Hardes K; Steinmetzer T; Than ME
    Biochemistry; 2018 Feb; 57(6):925-934. PubMed ID: 29314830
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor.
    Lazure C; Gauthier D; Jean F; Boudreault A; Seidah NG; Bennett HP; Hendy GN
    J Biol Chem; 1998 Apr; 273(15):8572-80. PubMed ID: 9535830
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.
    Shiryaev SA; Remacle AG; Ratnikov BI; Nelson NA; Savinov AY; Wei G; Bottini M; Rega MF; Parent A; Desjardins R; Fugere M; Day R; Sabet M; Pellecchia M; Liddington RC; Smith JW; Mustelin T; Guiney DG; Lebl M; Strongin AY
    J Biol Chem; 2007 Jul; 282(29):20847-53. PubMed ID: 17537721
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains.
    Fugère M; Limperis PC; Beaulieu-Audy V; Gagnon F; Lavigne P; Klarskov K; Leduc R; Day R
    J Biol Chem; 2002 Mar; 277(10):7648-56. PubMed ID: 11723118
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes.
    Basak A; Lazure C
    Biochem J; 2003 Jul; 373(Pt 1):231-9. PubMed ID: 12662153
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.