BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

202 related articles for article (PubMed ID: 19956691)

  • 1. Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN.
    Seemann P; Brehm A; König J; Reissner C; Stricker S; Kuss P; Haupt J; Renninger S; Nickel J; Sebald W; Groppe JC; Plöger F; Pohl J; Schmidt-von Kegler M; Walther M; Gassner I; Rusu C; Janecke AR; Dathe K; Mundlos S
    PLoS Genet; 2009 Nov; 5(11):e1000747. PubMed ID: 19956691
    [TBL] [Abstract][Full Text] [Related]  

  • 2. New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance.
    Schwaerzer GK; Hiepen C; Schrewe H; Nickel J; Ploeger F; Sebald W; Mueller T; Knaus P
    J Bone Miner Res; 2012 Feb; 27(2):429-42. PubMed ID: 21976273
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A GDF5 point mutation strikes twice--causing BDA1 and SYNS2.
    Degenkolbe E; König J; Zimmer J; Walther M; Reißner C; Nickel J; Plöger F; Raspopovic J; Sharpe J; Dathe K; Hecht JT; Mundlos S; Doelken SC; Seemann P
    PLoS Genet; 2013; 9(10):e1003846. PubMed ID: 24098149
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Noggin resistance contributes to the potent osteogenic capability of BMP9 in mesenchymal stem cells.
    Wang Y; Hong S; Li M; Zhang J; Bi Y; He Y; Liu X; Nan G; Su Y; Zhu G; Li R; Zhang W; Wang J; Zhang H; Kong Y; Shui W; Wu N; He Y; Chen X; Luu HH; Haydon RC; Shi LL; He TC; Qin J
    J Orthop Res; 2013 Nov; 31(11):1796-803. PubMed ID: 23861103
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN.
    Lehmann K; Seemann P; Silan F; Goecke TO; Irgang S; Kjaer KW; Kjaergaard S; Mahoney MJ; Morlot S; Reissner C; Kerr B; Wilkie AO; Mundlos S
    Am J Hum Genet; 2007 Aug; 81(2):388-96. PubMed ID: 17668388
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of a key residue mediating bone morphogenetic protein (BMP)-6 resistance to noggin inhibition allows for engineered BMPs with superior agonist activity.
    Song K; Krause C; Shi S; Patterson M; Suto R; Grgurevic L; Vukicevic S; van Dinther M; Falb D; Ten Dijke P; Alaoui-Ismaili MH
    J Biol Chem; 2010 Apr; 285(16):12169-80. PubMed ID: 20048150
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis.
    Tsumaki N; Nakase T; Miyaji T; Kakiuchi M; Kimura T; Ochi T; Yoshikawa H
    J Bone Miner Res; 2002 May; 17(5):898-906. PubMed ID: 12009021
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development.
    Okamoto M; Murai J; Yoshikawa H; Tsumaki N
    J Bone Miner Res; 2006 Jul; 21(7):1022-33. PubMed ID: 16813523
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Negative mutation screening of the NOG, BMPR1B, GDF5, and FGF9 genes indicates further genetic heterogeneity of the facioaudiosymphalangism syndrome.
    van den Ende JJ; Borra V; Van Hul W
    Clin Dysmorphol; 2013 Jan; 22(1):1-6. PubMed ID: 22968293
    [TBL] [Abstract][Full Text] [Related]  

  • 10. GDF5 is a second locus for multiple-synostosis syndrome.
    Dawson K; Seeman P; Sebald E; King L; Edwards M; Williams J; Mundlos S; Krakow D
    Am J Hum Genet; 2006 Apr; 78(4):708-12. PubMed ID: 16532400
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2.
    Seemann P; Schwappacher R; Kjaer KW; Krakow D; Lehmann K; Dawson K; Stricker S; Pohl J; Plöger F; Staub E; Nickel J; Sebald W; Knaus P; Mundlos S
    J Clin Invest; 2005 Sep; 115(9):2373-81. PubMed ID: 16127465
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Improved bone defect healing by a superagonistic GDF5 variant derived from a patient with multiple synostoses syndrome.
    Degenkolbe E; Schwarz C; Ott CE; König J; Schmidt-Bleek K; Ellinghaus A; Schmidt T; Lienau J; Plöger F; Mundlos S; Duda GN; Willie BM; Seemann P
    Bone; 2015 Apr; 73():111-9. PubMed ID: 25543012
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C.
    Stange K; Thieme T; Hertel K; Kuhfahl S; Janecke AR; Piza-Katzer H; Penttinen M; Hietala M; Dathe K; Mundlos S; Schwarz E; Seemann P
    J Mol Biol; 2014 Sep; 426(19):3221-3231. PubMed ID: 25092592
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Deletion mutants of BMP folding variants act as BMP antagonists and are efficient inhibitors for heterotopic ossification.
    Weber FE; Schmökel H; Oelgeschläger M; Nickel J; Maly FE; Hortschansky P; Grätz KW
    J Bone Miner Res; 2003 Dec; 18(12):2142-51. PubMed ID: 14672349
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding.
    Marcelino J; Sciortino CM; Romero MF; Ulatowski LM; Ballock RT; Economides AN; Eimon PM; Harland RM; Warman ML
    Proc Natl Acad Sci U S A; 2001 Sep; 98(20):11353-8. PubMed ID: 11562478
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein.
    Groppe J; Greenwald J; Wiater E; Rodriguez-Leon J; Economides AN; Kwiatkowski W; Baban K; Affolter M; Vale WW; Izpisua Belmonte JC; Choe S
    J Bone Joint Surg Am; 2003; 85-A Suppl 3():52-8. PubMed ID: 12925610
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Bone morphogenetic proteins.
    Chen D; Zhao M; Mundy GR
    Growth Factors; 2004 Dec; 22(4):233-41. PubMed ID: 15621726
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning.
    Capdevila J; Johnson RL
    Dev Biol; 1998 May; 197(2):205-17. PubMed ID: 9630747
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal.
    Wang J; Yu T; Wang Z; Ohte S; Yao RE; Zheng Z; Geng J; Cai H; Ge Y; Li Y; Xu Y; Zhang Q; Gusella JF; Fu Q; Pregizer S; Rosen V; Shen Y
    J Bone Miner Res; 2016 Apr; 31(4):882-9. PubMed ID: 26643732
    [TBL] [Abstract][Full Text] [Related]  

  • 20. BMPs, TGFβ, and border security at the interzone.
    Lyons KM; Rosen V
    Curr Top Dev Biol; 2019; 133():153-170. PubMed ID: 30902251
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.