166 related articles for article (PubMed ID: 19965760)
1. A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase.
Edwards MJ; Flatman RH; Mitchenall LA; Stevenson CE; Le TB; Clarke TA; McKay AR; Fiedler HP; Buttner MJ; Lawson DM; Maxwell A
Science; 2009 Dec; 326(5958):1415-8. PubMed ID: 19965760
[TBL] [Abstract][Full Text] [Related]
2. A new crystal structure of the bifunctional antibiotic simocyclinone D8 bound to DNA gyrase gives fresh insight into the mechanism of inhibition.
Hearnshaw SJ; Edwards MJ; Stevenson CE; Lawson DM; Maxwell A
J Mol Biol; 2014 May; 426(10):2023-33. PubMed ID: 24594357
[TBL] [Abstract][Full Text] [Related]
3. Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors.
Verghese J; Nguyen T; Oppegard LM; Seivert LM; Hiasa H; Ellis KC
Bioorg Med Chem Lett; 2013 Nov; 23(21):5874-7. PubMed ID: 24060488
[TBL] [Abstract][Full Text] [Related]
4. Crystallization and preliminary X-ray analysis of a complex formed between the antibiotic simocyclinone D8 and the DNA breakage-reunion domain of Escherichia coli DNA gyrase.
Edwards MJ; Flatman RH; Mitchenall LA; Stevenson CE; Maxwell A; Lawson DM
Acta Crystallogr Sect F Struct Biol Cryst Commun; 2009 Aug; 65(Pt 8):846-8. PubMed ID: 19652356
[TBL] [Abstract][Full Text] [Related]
5. Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.
Mustaev A; Malik M; Zhao X; Kurepina N; Luan G; Oppegard LM; Hiasa H; Marks KR; Kerns RJ; Berger JM; Drlica K
J Biol Chem; 2014 May; 289(18):12300-12. PubMed ID: 24497635
[TBL] [Abstract][Full Text] [Related]
6. Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.
Flatman RH; Howells AJ; Heide L; Fiedler HP; Maxwell A
Antimicrob Agents Chemother; 2005 Mar; 49(3):1093-100. PubMed ID: 15728908
[TBL] [Abstract][Full Text] [Related]
7. Mass spectrometry reveals that the antibiotic simocyclinone D8 binds to DNA gyrase in a "bent-over" conformation: evidence of positive cooperativity in binding.
Edwards MJ; Williams MA; Maxwell A; McKay AR
Biochemistry; 2011 May; 50(17):3432-40. PubMed ID: 21338149
[TBL] [Abstract][Full Text] [Related]
8. Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB.
Sissi C; Vazquez E; Chemello A; Mitchenall LA; Maxwell A; Palumbo M
Antimicrob Agents Chemother; 2010 Jan; 54(1):213-20. PubMed ID: 19858260
[TBL] [Abstract][Full Text] [Related]
9. Inhibition of human topoisomerases I and II by simocyclinone D8.
Oppegard LM; Nguyen T; Ellis KC; Hiasa H
J Nat Prod; 2012 Aug; 75(8):1485-9. PubMed ID: 22867097
[TBL] [Abstract][Full Text] [Related]
10. In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus.
Oppegard LM; Hamann BL; Streck KR; Ellis KC; Fiedler HP; Khodursky AB; Hiasa H
Antimicrob Agents Chemother; 2009 May; 53(5):2110-9. PubMed ID: 19273673
[TBL] [Abstract][Full Text] [Related]
11. Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics.
Alt S; Mitchenall LA; Maxwell A; Heide L
J Antimicrob Chemother; 2011 Sep; 66(9):2061-9. PubMed ID: 21693461
[TBL] [Abstract][Full Text] [Related]
12. Structural insights into simocyclinone as an antibiotic, effector ligand and substrate.
Buttner MJ; Schäfer M; Lawson DM; Maxwell A
FEMS Microbiol Rev; 2018 Jan; 42(1):. PubMed ID: 29126195
[TBL] [Abstract][Full Text] [Related]
13. SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone.
Schäfer M; Le TB; Hearnshaw SJ; Maxwell A; Challis GL; Wilkinson B; Buttner MJ
J Mol Biol; 2015 Jun; 427(12):2192-204. PubMed ID: 25861759
[TBL] [Abstract][Full Text] [Related]
14. Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance.
Gross CH; Parsons JD; Grossman TH; Charifson PS; Bellon S; Jernee J; Dwyer M; Chambers SP; Markland W; Botfield M; Raybuck SA
Antimicrob Agents Chemother; 2003 Mar; 47(3):1037-46. PubMed ID: 12604539
[TBL] [Abstract][Full Text] [Related]
15. A mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase II.
Gruger T; Nitiss JL; Maxwell A; Zechiedrich EL; Heisig P; Seeber S; Pommier Y; Strumberg D
Antimicrob Agents Chemother; 2004 Dec; 48(12):4495-504. PubMed ID: 15561817
[TBL] [Abstract][Full Text] [Related]
16. Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.
Kern G; Palmer T; Ehmann DE; Shapiro AB; Andrews B; Basarab GS; Doig P; Fan J; Gao N; Mills SD; Mueller J; Sriram S; Thresher J; Walkup GK
J Biol Chem; 2015 Aug; 290(34):20984-20994. PubMed ID: 26149691
[TBL] [Abstract][Full Text] [Related]
17. Alteration of Escherichia coli topoisomerase IV to novobiocin resistance.
Hardy CD; Cozzarelli NR
Antimicrob Agents Chemother; 2003 Mar; 47(3):941-7. PubMed ID: 12604525
[TBL] [Abstract][Full Text] [Related]
18. Novel Bacterial Topoisomerase Inhibitors Exploit Asp83 and the Intrinsic Flexibility of the DNA Gyrase Binding Site.
Franco-Ulloa S; La Sala G; Miscione GP; De Vivo M
Int J Mol Sci; 2018 Feb; 19(2):. PubMed ID: 29401640
[TBL] [Abstract][Full Text] [Related]
19. Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.
Mesleh MF; Cross JB; Zhang J; Kahmann J; Andersen OA; Barker J; Cheng RK; Felicetti B; Wood M; Hadfield AT; Scheich C; Moy TI; Yang Q; Shotwell J; Nguyen K; Lippa B; Dolle R; Ryan MD
Bioorg Med Chem Lett; 2016 Feb; 26(4):1314-8. PubMed ID: 26786695
[TBL] [Abstract][Full Text] [Related]
20. Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors.
Gjorgjieva M; Tomašič T; Barančokova M; Katsamakas S; Ilaš J; Tammela P; Peterlin Mašič L; Kikelj D
J Med Chem; 2016 Oct; 59(19):8941-8954. PubMed ID: 27541007
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]