268 related articles for article (PubMed ID: 19966802)
1. Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.
Wang H; Bauzon F; Ji P; Xu X; Sun D; Locker J; Sellers RS; Nakayama K; Nakayama KI; Cobrinik D; Zhu L
Nat Genet; 2010 Jan; 42(1):83-8. PubMed ID: 19966802
[TBL] [Abstract][Full Text] [Related]
2. Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.
Lu Z; Bauzon F; Fu H; Cui J; Zhao H; Nakayama K; Nakayama KI; Zhu L
Nat Commun; 2014 Mar; 5():3463. PubMed ID: 24632684
[TBL] [Abstract][Full Text] [Related]
3. p27T187A knockin identifies Skp2/Cks1 pocket inhibitors for advanced prostate cancer.
Zhao H; Lu Z; Bauzon F; Fu H; Cui J; Locker J; Zhu L
Oncogene; 2017 Jan; 36(1):60-70. PubMed ID: 27181203
[TBL] [Abstract][Full Text] [Related]
4. Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age.
Zhao H; Bauzon F; Bi E; Yu JJ; Fu H; Lu Z; Cui J; Jeon H; Zang X; Ye BH; Zhu L
J Biol Chem; 2015 Feb; 290(9):5797-809. PubMed ID: 25583987
[TBL] [Abstract][Full Text] [Related]
5. Racing to block tumorigenesis after pRb loss: an innocuous point mutation wins with synthetic lethality.
Bauzon F; Zhu L
Cell Cycle; 2010 Jun; 9(11):2118-23. PubMed ID: 20505340
[TBL] [Abstract][Full Text] [Related]
6. Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis.
Zhao H; Wang H; Bauzon F; Lu Z; Fu H; Cui J; Zhu L
J Biol Chem; 2016 May; 291(19):10201-9. PubMed ID: 26966181
[TBL] [Abstract][Full Text] [Related]
7. Targeted Inhibition of the E3 Ligase SCF
Zhao H; Iqbal NJ; Sukrithan V; Nicholas C; Xue Y; Yu C; Locker J; Zou J; Schwartz EL; Zhu L
Cancer Res; 2020 Jun; 80(11):2355-2367. PubMed ID: 32265224
[TBL] [Abstract][Full Text] [Related]
8. Targeting the untargetable: RB1-deficient tumours are vulnerable to Skp2 ubiquitin ligase inhibition.
Gupta P; Zhao H; Hoang B; Schwartz EL
Br J Cancer; 2022 Oct; 127(6):969-975. PubMed ID: 35752713
[TBL] [Abstract][Full Text] [Related]
9. Targeted pharmacologic inhibition of S-phase kinase-associated protein 2 (SKP2) mediated cell cycle regulation in lung and other RB-Related cancers: A brief review of current status and future prospects.
Elahi AH; Morales CS; Xu XL; Eliades A; Patsalis PC; Abramson DH; Jhanwar SC
Adv Biol Regul; 2023 May; 88():100964. PubMed ID: 37004354
[TBL] [Abstract][Full Text] [Related]
10. p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function.
Liu S; Yamauchi H
Cancer Lett; 2009 Dec; 286(2):240-9. PubMed ID: 19631451
[TBL] [Abstract][Full Text] [Related]
11. The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma.
Wang J; Aldahamsheh O; Ferrena A; Borjihan H; Singla A; Yaguare S; Singh S; Viscarret V; Tingling J; Zi X; Lo Y; Gorlick R; Zheng D; Schwartz EL; Zhao H; Yang R; Geller DS; Hoang BH
Ann N Y Acad Sci; 2021 Apr; 1490(1):90-104. PubMed ID: 33594717
[TBL] [Abstract][Full Text] [Related]
12. Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice.
Suzuki S; Fukasawa H; Kitagawa K; Uchida C; Hattori T; Isobe T; Oda T; Misaki T; Ohashi N; Nakayama K; Nakayama KI; Hishida A; Yamamoto T; Kitagawa M
Am J Pathol; 2007 Aug; 171(2):473-83. PubMed ID: 17620370
[TBL] [Abstract][Full Text] [Related]
13. A Skp2 autoinduction loop and restriction point control.
Yung Y; Walker JL; Roberts JM; Assoian RK
J Cell Biol; 2007 Aug; 178(5):741-7. PubMed ID: 17724117
[TBL] [Abstract][Full Text] [Related]
14. Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors.
Zhao H; Bauzon F; Fu H; Lu Z; Cui J; Nakayama K; Nakayama KI; Locker J; Zhu L
Cancer Cell; 2013 Nov; 24(5):645-59. PubMed ID: 24229711
[TBL] [Abstract][Full Text] [Related]
15. SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells.
Xu XL; Li Z; Liu A; Fan X; Hu DN; Qi DL; Chitty DW; Jia R; Qui J; Wang JQ; Sharaf J; Zou J; Weiss R; Huang H; Joseph WJ; Ng L; Rosen R; Shen B; Reid MW; Forrest D; Abramson DH; Singer S; Cobrinik D; Jhanwar SC
Cancer Res; 2017 Dec; 77(24):6838-6850. PubMed ID: 28972075
[TBL] [Abstract][Full Text] [Related]
16. Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model.
Li X; Yokoyama NN; Zhang S; Ding L; Liu HM; Lilly MB; Mercola D; Zi X
Oncotarget; 2015 Dec; 6(39):41809-24. PubMed ID: 26497688
[TBL] [Abstract][Full Text] [Related]
17. Targeted inhibition of SCF
Wang J; Ferrena A; Zhang R; Singh S; Viscarret V; Al-Harden W; Aldahamsheh O; Borjihan H; Singla A; Yaguare S; Tingling J; Zi X; Lo Y; Gorlick R; Schwartz EL; Zhao H; Yang R; Geller DS; Zheng D; Hoang BH
Oncogene; 2024 Mar; 43(13):962-975. PubMed ID: 38355807
[TBL] [Abstract][Full Text] [Related]
18. S-phase kinase-associated protein 2 knockdown blocks colorectal cancer growth via regulation of both p27 and p16 expression.
Xu SY; Wang F; Wei G; Wang B; Yang JY; Huang YZ; Zhang L; Zheng F; Guo LY; Wang JN; Tang JM
Cancer Gene Ther; 2013 Dec; 20(12):690-4. PubMed ID: 24336114
[TBL] [Abstract][Full Text] [Related]
19. The amelioration of renal damage in Skp2-deficient mice canceled by p27 Kip1 deficiency in Skp2-/- p27-/- mice.
Suzuki S; Fukasawa H; Misaki T; Togawa A; Ohashi N; Kitagawa K; Kotake Y; Liu N; Niida H; Nakayama K; Nakayama KI; Yamamoto T; Kitagawa M
PLoS One; 2012; 7(4):e36249. PubMed ID: 22558406
[TBL] [Abstract][Full Text] [Related]
20. NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21/p27 axis.
Shen L; Qu X; Li H; Xu C; Wei M; Wang Q; Ru Y; Liu B; Xu Y; Li K; Hu J; Wang L; Ma Y; Li M; Lai X; Gao L; Wu K; Yao L; Zheng J; Zhang J
Oncogene; 2018 Mar; 37(13):1759-1774. PubMed ID: 29343851
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]