These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

127 related articles for article (PubMed ID: 1998952)

  • 1. Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice.
    Endo K; Igarashi Y; Nisar M; Zhou QH; Hakomori S
    Cancer Res; 1991 Mar; 51(6):1613-8. PubMed ID: 1998952
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation.
    Okoshi H; Hakomori S; Nisar M; Zhou QH; Kimura S; Tashiro K; Igarashi Y
    Cancer Res; 1991 Nov; 51(22):6019-24. PubMed ID: 1657377
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils.
    Kimura S; Kawa S; Ruan F; Nisar M; Sadahira Y; Hakomori S; Igarashi Y
    Biochem Pharmacol; 1992 Oct; 44(8):1585-95. PubMed ID: 1329769
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells.
    Igarashi Y; Kitamura K; Toyokuni T; Dean B; Fenderson B; Ogawass T; Hakomori S
    J Biol Chem; 1990 Apr; 265(10):5385-9. PubMed ID: 2318819
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells.
    Shirahama T; Sweeney EA; Sakakura C; Singhal AK; Nishiyama K; Akiyama S; Hakomori S; Igarashi Y
    Clin Cancer Res; 1997 Feb; 3(2):257-64. PubMed ID: 9815681
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Downregulation of GMP-140 (CD62 or PADGEM) expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine.
    Handa K; Igarashi Y; Nisar M; Hakomori S
    Biochemistry; 1991 Dec; 30(50):11682-6. PubMed ID: 1721534
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III.
    Park YS; Hakomori S; Kawa S; Ruan F; Igarashi Y
    Cancer Res; 1994 Apr; 54(8):2213-7. PubMed ID: 8174128
    [TBL] [Abstract][Full Text] [Related]  

  • 8. N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.
    Edsall LC; Van Brocklyn JR; Cuvillier O; Kleuser B; Spiegel S
    Biochemistry; 1998 Sep; 37(37):12892-8. PubMed ID: 9737868
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines.
    Sweeney EA; Sakakura C; Shirahama T; Masamune A; Ohta H; Hakomori S; Igarashi Y
    Int J Cancer; 1996 May; 66(3):358-66. PubMed ID: 8621258
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Characterization of N,N,-dimethyl-D-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition.
    Kim HL; Sacket SJ; Han M; Im DS
    Prostaglandins Other Lipid Mediat; 2008 Jun; 86(1-4):18-25. PubMed ID: 18316219
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Suppression of osteoclastogenesis by N,N-dimethyl-D-erythro-sphingosine: a sphingosine kinase inhibition-independent action.
    Kim HJ; Lee Y; Chang EJ; Kim HM; Hong SP; Lee ZH; Ryu J; Kim HH
    Mol Pharmacol; 2007 Aug; 72(2):418-28. PubMed ID: 17504945
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Differential signaling of sphingosine derivatives in U937 human monocytes depends on the degree of N-methylation.
    Kim HL; Han M; Im DS
    Prostaglandins Other Lipid Mediat; 2008 Jun; 86(1-4):68-72. PubMed ID: 18467142
    [TBL] [Abstract][Full Text] [Related]  

  • 13. [Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro].
    Yin GJ; Lan KH; Hu CY; Lu Q; Tang W; Wang SF
    Zhonghua Zhong Liu Za Zhi; 2012 Feb; 34(2):96-9. PubMed ID: 22780925
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities.
    Igarashi Y; Hakomori S; Toyokuni T; Dean B; Fujita S; Sugimoto M; Ogawa T; el-Ghendy K; Racker E
    Biochemistry; 1989 Aug; 28(17):6796-800. PubMed ID: 2479412
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cooperative inhibitory effect of n,n,n-trimethylsphingosine and sphingosine-1-phosphate, co-incorporated in liposomes, on b16 melanoma cell metastasis - cell-membrane signaling as a target in cancer-therapy .4.
    Park Y; Ruan F; Hakomori S; Igarashi Y
    Int J Oncol; 1995 Sep; 7(3):487-94. PubMed ID: 21552864
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synergistic inhibition of growth and induction of apoptosis by 8-chloro-cAMP and paclitaxel or cisplatin in human cancer cells.
    Tortora G; di Isernia G; Sandomenico C; Bianco R; Pomatico G; Pepe S; Bianco AR; Ciardiello F
    Cancer Res; 1997 Nov; 57(22):5107-11. PubMed ID: 9371510
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.
    Jin ZQ; Karliner JS
    Cardiovasc Res; 2006 Sep; 71(4):725-34. PubMed ID: 16831409
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Tumor apoptosis induced by epoxide-containing piperazines, a new class of anti-cancer agents.
    Eilon GF; Gu J; Slater LM; Hara K; Jacobs JW
    Cancer Chemother Pharmacol; 2000; 45(3):183-91. PubMed ID: 10663635
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Selectivity of sphingosine-induced apoptosis. Lack of activity of DL-erythyro-dihydrosphingosine.
    Sakakura C; Sweeney EA; Shirahama T; Hagiwara A; Yamaguchi T; Takahashi T; Hakomori S; Igarashi Y
    Biochem Biophys Res Commun; 1998 May; 246(3):827-30. PubMed ID: 9618297
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dimethylsphingosine regulates intracellular pH and Ca(2+) in human monocytes.
    Lee EH; Lee YK; Im YJ; Kim JH; Okajima F; Im DS
    J Pharmacol Sci; 2006 Apr; 100(4):289-96. PubMed ID: 16575153
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.