BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

264 related articles for article (PubMed ID: 20000419)

  • 1. Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.
    Combs AP
    J Med Chem; 2010 Mar; 53(6):2333-44. PubMed ID: 20000419
    [No Abstract]   [Full Text] [Related]  

  • 2. Novel protein tyrosine phosphatase 1B inhibitors: interaction requirements for improved intracellular efficacy in type 2 diabetes mellitus and obesity control.
    Popov D
    Biochem Biophys Res Commun; 2011 Jul; 410(3):377-81. PubMed ID: 21683066
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development.
    Barr AJ
    Future Med Chem; 2010 Oct; 2(10):1563-76. PubMed ID: 21426149
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24.
    Wan ZK; Lee J; Hotchandani R; Moretto A; Binnun E; Wilson DP; Kirincich SJ; Follows BC; Ipek M; Xu W; Joseph-McCarthy D; Zhang YL; Tam M; Erbe DV; Tobin JF; Li W; Tam SY; Mansour TS; Wu J
    ChemMedChem; 2008 Oct; 3(10):1525-9. PubMed ID: 18798205
    [No Abstract]   [Full Text] [Related]  

  • 5. Protein tyrosine phosphatase 1B inhibitors for diabetes.
    Johnson TO; Ermolieff J; Jirousek MR
    Nat Rev Drug Discov; 2002 Sep; 1(9):696-709. PubMed ID: 12209150
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-based virtual screening approach to identify novel classes of PTP1B inhibitors.
    Park H; Bhattarai BR; Ham SW; Cho H
    Eur J Med Chem; 2009 Aug; 44(8):3280-4. PubMed ID: 19269068
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B.
    Xu JQ; Shen Q; Li J; Hu LH
    Bioorg Med Chem; 2010 Jun; 18(11):3934-9. PubMed ID: 20472439
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Protein tyrosine phosphatase 1B inhibitors for the treatment of type 2 diabetes and obesity: recent advances.
    Harley EA; Levens N
    Curr Opin Investig Drugs; 2003 Oct; 4(10):1179-89. PubMed ID: 14649209
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of orally active, potent, and selective benzotriazole-based PTP1B inhibitors.
    Patel D; Jain M; Shah SR; Bahekar R; Jadav P; Darji B; Siriki Y; Bandyopadhyay D; Joharapurkar A; Kshirsagar S; Patel H; Shaikh M; Sairam KV; Patel P
    ChemMedChem; 2011 Jun; 6(6):1011-6. PubMed ID: 21506278
    [No Abstract]   [Full Text] [Related]  

  • 10. Recent Advances in Protein Tyrosine Phosphatase 1B Targeted Drug Discovery for Type II Diabetes and Obesity.
    Maheshwari N; Karthikeyan C; Trivedi P; Moorthy NSHN
    Curr Drug Targets; 2018; 19(5):551-575. PubMed ID: 28228082
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase.
    Maccari R; Ottanà R; Ciurleo R; Paoli P; Manao G; Camici G; Laggner C; Langer T
    ChemMedChem; 2009 Jun; 4(6):957-62. PubMed ID: 19288492
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Studies of the mechanism of selectivity of protein tyrosine phosphatase 1B (PTP1B) bidentate inhibitors using molecular dynamics simulations and free energy calculations.
    Fang L; Zhang H; Cui W; Ji M
    J Chem Inf Model; 2008 Oct; 48(10):2030-41. PubMed ID: 18831546
    [TBL] [Abstract][Full Text] [Related]  

  • 13. [Does inhibition of tyrosine phosphatase 1B protect from obesity and type 2 diabetes?].
    Ukkola O; Santaniemi M
    Duodecim; 2002; 118(18):1857-62. PubMed ID: 12422667
    [No Abstract]   [Full Text] [Related]  

  • 14. Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors.
    Patel D; Jain M; Shah SR; Bahekar R; Jadav P; Joharapurkar A; Dhanesha N; Shaikh M; Sairam KV; Kapadnis P
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1111-7. PubMed ID: 22189136
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Protein tyrosine phosphatase 1B as a target for the treatment of impaired glucose tolerance and type II diabetes.
    Liu G; Trevillyan JM
    Curr Opin Investig Drugs; 2002 Nov; 3(11):1608-16. PubMed ID: 12476961
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis of protein tyrosine phosphatase 1B inhibitors: model validation and docking studies.
    Saxena AK; Pandey G; Gupta S; Singh AB; Srivastava AK
    Bioorg Med Chem Lett; 2009 Apr; 19(8):2320-3. PubMed ID: 19282172
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.
    Dai HL; Gao LX; Yang Y; Li JY; Cheng JG; Li J; Wen R; Peng YQ; Zheng JB
    Bioorg Med Chem Lett; 2012 Dec; 22(24):7440-3. PubMed ID: 23122522
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.
    Douty B; Wayland B; Ala PJ; Bower MJ; Pruitt J; Bostrom L; Wei M; Klabe R; Gonneville L; Wynn R; Burn TC; Liu PC; Combs AP; Yue EW
    Bioorg Med Chem Lett; 2008 Jan; 18(1):66-71. PubMed ID: 18037290
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rationalizing protein-ligand interactions for PTP1B inhibitors using computational methods.
    Ajmani S; Karanam S; Kulkarni SA
    Chem Biol Drug Des; 2009 Dec; 74(6):582-95. PubMed ID: 19824894
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-based design of protein tyrosine phosphatase-1B inhibitors.
    Black E; Breed J; Breeze AL; Embrey K; Garcia R; Gero TW; Godfrey L; Kenny PW; Morley AD; Minshull CA; Pannifer AD; Read J; Rees A; Russell DJ; Toader D; Tucker J
    Bioorg Med Chem Lett; 2005 May; 15(10):2503-7. PubMed ID: 15863305
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.