These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 20004097)

  • 1. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).
    Léger S; Black WC; Deschenes D; Dolman S; Falgueyret JP; Gagnon M; Guiral S; Huang Z; Guay J; Leblanc Y; Li CS; Massé F; Oballa R; Zhang L
    Bioorg Med Chem Lett; 2010 Jan; 20(2):499-502. PubMed ID: 20004097
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats.
    Uto Y; Ogata T; Kiyotsuka Y; Ueno Y; Miyazawa Y; Kurata H; Deguchi T; Watanabe N; Konishi M; Okuyama R; Kurikawa N; Takagi T; Wakimoto S; Ohsumi J
    Bioorg Med Chem Lett; 2010 Jan; 20(1):341-5. PubMed ID: 19926281
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.
    Yang SM; Tang Y; Rano T; Lu H; Kuo GH; Gaul MD; Li Y; Ho G; Lang W; Conway JG; Liang Y; Lenhard JM; Demarest KT; Murray WV
    Bioorg Med Chem Lett; 2014 Mar; 24(5):1437-41. PubMed ID: 24405703
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors.
    Isabel E; Powell DA; Black WC; Chan CC; Crane S; Gordon R; Guay J; Guiral S; Huang Z; Robichaud J; Skorey K; Tawa P; Xu L; Zhang L; Oballa R
    Bioorg Med Chem Lett; 2011 Jan; 21(1):479-83. PubMed ID: 21074991
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Thiazole analog as stearoyl-CoA desaturase 1 inhibitor.
    Li CS; Belair L; Guay J; Murgasva R; Sturkenboom W; Ramtohul YK; Zhang L; Huang Z
    Bioorg Med Chem Lett; 2009 Sep; 19(17):5214-7. PubMed ID: 19632834
    [TBL] [Abstract][Full Text] [Related]  

  • 6. SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors.
    Ramtohul YK; Black C; Chan CC; Crane S; Guay J; Guiral S; Huang Z; Oballa R; Xu LJ; Zhang L; Li CS
    Bioorg Med Chem Lett; 2010 Mar; 20(5):1593-7. PubMed ID: 20137926
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Development of a high-throughput screening assay for stearoyl-CoA desaturase using rat liver microsomes, deuterium labeled stearoyl-CoA and mass spectrometry.
    Soulard P; McLaughlin M; Stevens J; Connolly B; Coli R; Wang L; Moore J; Kuo MS; LaMarr WA; Ozbal CC; Bhat BG
    Anal Chim Acta; 2008 Oct; 627(1):105-11. PubMed ID: 18790133
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.
    Koltun DO; Vasilevich NI; Parkhill EQ; Glushkov AI; Zilbershtein TM; Mayboroda EI; Boze MA; Cole AG; Henderson I; Zautke NA; Brunn SA; Chu N; Hao J; Mollova N; Leung K; Chisholm JW; Zablocki J
    Bioorg Med Chem Lett; 2009 Jun; 19(11):3050-3. PubMed ID: 19394219
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents.
    Imamura K; Tomita N; Kawakita Y; Ito Y; Ono K; Nii N; Miyazaki T; Yonemori K; Tawada M; Sumi H; Satoh Y; Yamamoto Y; Miyahisa I; Sasaki M; Satomi Y; Hirayama M; Nishigaki R; Maezaki H
    Bioorg Med Chem; 2017 Jul; 25(14):3768-3779. PubMed ID: 28571972
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors.
    Ramtohul YK; Powell D; Leclerc JP; Leger S; Oballa R; Black C; Isabel E; Li CS; Crane S; Robichaud J; Guay J; Guiral S; Zhang L; Huang Z
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5692-6. PubMed ID: 21871798
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide.
    Uto Y; Ogata T; Harada J; Kiyotsuka Y; Ueno Y; Miyazawa Y; Kurata H; Deguchi T; Watanabe N; Takagi T; Wakimoto S; Okuyama R; Abe M; Kurikawa N; Kawamura S; Yamato M; Osumi J
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4151-8. PubMed ID: 19540759
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine] analogs.
    Uto Y; Ueno Y; Kiyotsuka Y; Miyazawa Y; Kurata H; Ogata T; Yamada M; Deguchi T; Konishi M; Takagi T; Wakimoto S; Ohsumi J
    Eur J Med Chem; 2010 Nov; 45(11):4788-96. PubMed ID: 20801551
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series.
    Lachance N; Gareau Y; Guiral S; Huang Z; Isabel E; Leclerc JP; Léger S; Martins E; Nadeau C; Oballa RM; Ouellet SG; Powell DA; Ramtohul YK; Tranmer GK; Trinh T; Wang H; Zhang L
    Bioorg Med Chem Lett; 2012 Jan; 22(2):980-4. PubMed ID: 22209206
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors.
    Koltun DO; Parkhill EQ; Vasilevich NI; Glushkov AI; Zilbershtein TM; Ivanov AV; Cole AG; Henderson I; Zautke NA; Brunn SA; Mollova N; Leung K; Chisholm JW; Zablocki J
    Bioorg Med Chem Lett; 2009 Apr; 19(7):2048-52. PubMed ID: 19249203
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors.
    Xin Z; Zhao H; Serby MD; Liu B; Liu M; Szczepankiewicz BG; Nelson LT; Smith HT; Suhar TS; Janis RS; Cao N; Camp HS; Collins CA; Sham HL; Surowy TK; Liu G
    Bioorg Med Chem Lett; 2008 Aug; 18(15):4298-302. PubMed ID: 18632269
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors.
    Liu G; Lynch JK; Freeman J; Liu B; Xin Z; Zhao H; Serby MD; Kym PR; Suhar TS; Smith HT; Cao N; Yang R; Janis RS; Krauser JA; Cepa SP; Beno DW; Sham HL; Collins CA; Surowy TK; Camp HS
    J Med Chem; 2007 Jun; 50(13):3086-100. PubMed ID: 17530838
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization.
    Matter H; Zoller G; Herling AW; Sanchez-Arias JA; Philippo C; Namane C; Kohlmann M; Pfenninger A; Voss MD
    Bioorg Med Chem Lett; 2013 Mar; 23(6):1817-22. PubMed ID: 23395660
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation.
    Uto Y; Ogata T; Kiyotsuka Y; Miyazawa Y; Ueno Y; Kurata H; Deguchi T; Yamada M; Watanabe N; Takagi T; Wakimoto S; Okuyama R; Konishi M; Kurikawa N; Kono K; Osumi J
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4159-66. PubMed ID: 19541482
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.
    Yang SM; Tang Y; Zhang R; Lu H; Kuo GH; Gaul MD; Li Y; Ho G; Conway JG; Liang Y; Lenhard JM; Demarest KT; Murray WV
    Bioorg Med Chem Lett; 2013 Dec; 23(24):6773-6. PubMed ID: 24153205
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nicotinic acids: liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy.
    Powell DA; Black WC; Bleasby K; Chan CC; Deschenes D; Gagnon M; Gordon R; Guay J; Guiral S; Hafey MJ; Huang Z; Isabel E; Leblanc Y; Styhler A; Xu LJ; Zhang L; Oballa RM
    Bioorg Med Chem Lett; 2011 Dec; 21(24):7281-6. PubMed ID: 22047692
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.