BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

198 related articles for article (PubMed ID: 20004212)

  • 1. Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).
    Metry KJ; Neale JR; Doll MA; Howarth AL; States JC; McGregor WG; Pierce WM; Hein DW
    Mutat Res; 2010 Feb; 684(1-2):66-73. PubMed ID: 20004212
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline-induced DNA adduct formation and mutagenesis in DNA repair-deficient Chinese hamster ovary cells expressing human cytochrome P4501A1 and rapid or slow acetylator N-acetyltransferase 2.
    Bendaly J; Zhao S; Neale JR; Metry KJ; Doll MA; States JC; Pierce WM; Hein DW
    Cancer Epidemiol Biomarkers Prev; 2007 Jul; 16(7):1503-9. PubMed ID: 17627018
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced DNA adducts and genotoxicity in chinese hamster ovary (CHO) cells expressing human CYP1A2 and rapid or slow acetylator N-acetyltransferase 2.
    Metry KJ; Zhao S; Neale JR; Doll MA; States JC; McGregor WG; Pierce WM; Hein DW
    Mol Carcinog; 2007 Jul; 46(7):553-63. PubMed ID: 17295238
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Role of Human N-Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen-Induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay.
    Baldauf KJ; Salazar-González RA; Doll MA; Pierce WM; States JC; Hein DW
    Environ Mol Mutagen; 2020 Feb; 61(2):235-245. PubMed ID: 31490564
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.
    Metry KJ; Neale JR; Bendaly J; Smith NB; Pierce WM; Hein DW
    Drug Metab Dispos; 2009 Nov; 37(11):2123-6. PubMed ID: 19666988
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic amine exposure.
    Hein DW; Salazar-González RA; Doll MA; Zang Y
    Arch Toxicol; 2023 Oct; 97(10):2697-2705. PubMed ID: 37592049
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.
    Bendaly J; Doll MA; Millner LM; Metry KJ; Smith NB; Pierce WM; Hein DW
    Mutat Res; 2009 Dec; 671(1-2):13-9. PubMed ID: 19682468
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity and DNA adducts.
    Bendaly J; Metry KJ; Doll MA; Jiang G; States JC; Smith NB; Neale JR; Holloman JL; Pierce WM; Hein DW
    Xenobiotica; 2009 May; 39(5):399-406. PubMed ID: 19301197
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Yanagawa Y; Sawada M; Deguchi T; Gonzalez FJ; Kamataki T
    Cancer Res; 1994 Jul; 54(13):3422-7. PubMed ID: 8012961
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indole.
    Turesky RJ; Bendaly J; Yasa I; Doll MA; Hein DW
    Chem Res Toxicol; 2009 Apr; 22(4):726-33. PubMed ID: 19243127
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes.
    Habil MR; Salazar-González RA; Doll MA; Hein DW
    Arch Toxicol; 2022 Nov; 96(11):2999-3012. PubMed ID: 36040704
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine.
    Turesky RJ; Rossi SC; Welti DH; Lay JO; Kadlubar FF
    Chem Res Toxicol; 1992; 5(4):479-90. PubMed ID: 1391614
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
    Sadrieh N; Snyderwine EG
    Carcinogenesis; 1995 Jul; 16(7):1549-55. PubMed ID: 7614688
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Quantitation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline DNA adducts in specific sequences using alkali or uvrABC excinuclease.
    Nouso K; Bohr VA; Schut HA; Snyderwine EG
    Mol Carcinog; 1993; 7(2):126-34. PubMed ID: 8457290
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Simultaneous expression of human CYP3A7 and N-acetyltransferase in Chinese hamster CHL cells results in high cytotoxicity for carcinogenic heterocyclic amines.
    Hashimoto H; Yanagawa Y; Sawada M; Itoh S; Deguchi T; Kamataki T
    Arch Biochem Biophys; 1995 Jul; 320(2):323-9. PubMed ID: 7625840
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 32P-postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys.
    Snyderwine EG; Davis CD; Nouso K; Roller PP; Schut HA
    Carcinogenesis; 1993 Jul; 14(7):1389-95. PubMed ID: 8330355
    [TBL] [Abstract][Full Text] [Related]  

  • 17. DNA adduct levels and intestinal lesions in congenic rapid and slow acetylator syrian hamsters admi food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).
    Steffensen IL; Fretland AJ; Paulsen JE; Feng Y; Eide TJ; Devanaboyina US; Hein DW; Alexander J
    Pharmacol Toxicol; 2000 Jun; 86(6):257-63. PubMed ID: 10895988
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interindividual variation in the metabolic activation of heterocyclic amines and their N-hydroxy derivatives in primary cultures of human mammary epithelial cells.
    Stone EM; Williams JA; Grover PL; Gusterson BA; Phillips DH
    Carcinogenesis; 1998 May; 19(5):873-9. PubMed ID: 9635877
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Differential effect of acetyltransferase expression on the genotoxicity of heterocyclic amines in CHO cells.
    Wu RW; Tucker JD; Sorensen KJ; Thompson LH; Felton JS
    Mutat Res; 1997 Apr; 390(1-2):93-103. PubMed ID: 9150757
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta mice and c-myc/lacZ double transgenic mice.
    Davis CD; Dacquel EJ; Schut HA; Thorgeirsson SS; Snyderwine EG
    Mutat Res; 1996 Sep; 356(2):287-96. PubMed ID: 8841498
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.