166 related articles for article (PubMed ID: 20012148)
1. Lead identification and optimization of diaminopyrimidines as histamine H4 receptor ligands.
Sander K; Kottke T; Proschak E; Tanrikulu Y; Schneider EH; Seifert R; Schneider G; Stark H
Inflamm Res; 2010 Mar; 59 Suppl 2():S249-51. PubMed ID: 20012148
[TBL] [Abstract][Full Text] [Related]
2. 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization.
Sander K; Kottke T; Tanrikulu Y; Proschak E; Weizel L; Schneider EH; Seifert R; Schneider G; Stark H
Bioorg Med Chem; 2009 Oct; 17(20):7186-96. PubMed ID: 19773175
[TBL] [Abstract][Full Text] [Related]
3. 2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor-H1/H4-receptor selectivity.
Hammer SG; Gobleder S; Naporra F; Wittmann HJ; Elz S; Heinrich MR; Strasser A
Bioorg Med Chem Lett; 2016 Jan; 26(2):292-300. PubMed ID: 26718844
[TBL] [Abstract][Full Text] [Related]
4. Piperazine modification in 2,4,6-triaminopyrimidine derivatives as histamine H4 receptor ligands.
Schreeb A; Walter M; Odadzic D; Schwed JS; Weizel L; Stark H
Pharmazie; 2013 Jul; 68(7):521-5. PubMed ID: 23923631
[TBL] [Abstract][Full Text] [Related]
5. Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening.
Kiss R; Kiss B; Könczöl A; Szalai F; Jelinek I; László V; Noszál B; Falus A; Keseru GM
J Med Chem; 2008 Jun; 51(11):3145-53. PubMed ID: 18459760
[TBL] [Abstract][Full Text] [Related]
6. Major advances in the development of histamine H4 receptor ligands.
Smits RA; Leurs R; de Esch IJ
Drug Discov Today; 2009 Aug; 14(15-16):745-53. PubMed ID: 19477292
[TBL] [Abstract][Full Text] [Related]
7. Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.
Mowbray CE; Bell AS; Clarke NP; Collins M; Jones RM; Lane CA; Liu WL; Newman SD; Paradowski M; Schenck EJ; Selby MD; Swain NA; Williams DH
Bioorg Med Chem Lett; 2011 Nov; 21(21):6596-602. PubMed ID: 21920751
[TBL] [Abstract][Full Text] [Related]
8. Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.
Savall BM; Chavez F; Tays K; Dunford PJ; Cowden JM; Hack MD; Wolin RL; Thurmond RL; Edwards JP
J Med Chem; 2014 Mar; 57(6):2429-39. PubMed ID: 24495018
[TBL] [Abstract][Full Text] [Related]
9. Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.
Smits RA; Lim HD; van der Meer T; Kuhne S; Bessembinder K; Zuiderveld OP; Wijtmans M; de Esch IJ; Leurs R
Bioorg Med Chem Lett; 2012 Jan; 22(1):461-7. PubMed ID: 22153663
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and functional characterization of imbutamine analogs as histamine H3 and H4 receptor ligands.
Geyer R; Kaske M; Baumeister P; Buschauer A
Arch Pharm (Weinheim); 2014 Feb; 347(2):77-88. PubMed ID: 24493592
[TBL] [Abstract][Full Text] [Related]
11. Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands.
Savall BM; Edwards JP; Venable JD; Buzard DJ; Thurmond R; Hack M; McGovern P
Bioorg Med Chem Lett; 2010 Jun; 20(11):3367-71. PubMed ID: 20452213
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and evaluation of a 2-benzothiazolylphenylmethyl ether class of histamine H4 receptor antagonists.
Labeeuw O; Levoin N; Billot X; Danvy D; Calmels T; Krief S; Ligneau X; Berrebi-Bertrand I; Robert P; Lecomte JM; Schwartz JC; Capet M
Bioorg Med Chem Lett; 2016 Nov; 26(21):5263-5266. PubMed ID: 27692832
[TBL] [Abstract][Full Text] [Related]
13. Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor.
Nijmeijer S; Engelhardt H; Schultes S; van de Stolpe AC; Lusink V; de Graaf C; Wijtmans M; Haaksma EE; de Esch IJ; Stachurski K; Vischer HF; Leurs R
Br J Pharmacol; 2013 Sep; 170(1):89-100. PubMed ID: 23347159
[TBL] [Abstract][Full Text] [Related]
14. The effect of pK(a) on pyrimidine/pyridine-derived histamine H4 ligands.
Savall BM; Meduna SP; Venable J; Wei J; Smith RC; Hack MD; Thurmond RL; McGovern P; Edwards JP
Bioorg Med Chem Lett; 2014 Dec; 24(23):5489-92. PubMed ID: 25455490
[TBL] [Abstract][Full Text] [Related]
15. Histamine H4 receptor ligands and their potential therapeutic applications.
Kiss R; Keseru GM
Expert Opin Ther Pat; 2009 Feb; 19(2):119-35. PubMed ID: 19441913
[TBL] [Abstract][Full Text] [Related]
16. A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes.
Höring C; Seibel U; Tropmann K; Grätz L; Mönnich D; Pitzl S; Bernhardt G; Pockes S; Strasser A
Int J Mol Sci; 2020 Nov; 21(22):. PubMed ID: 33182741
[TBL] [Abstract][Full Text] [Related]
17. G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations.
Krueger KM; Witte DG; Ireland-Denny L; Miller TR; Baranowski JL; Buckner S; Milicic I; Esbenshade TA; Hancock AA
J Pharmacol Exp Ther; 2005 Jul; 314(1):271-81. PubMed ID: 15821027
[TBL] [Abstract][Full Text] [Related]
18. Pharmacological profile of astemizole-derived compounds at the histamine H1 and H4 receptor--H1/H4 receptor selectivity.
Wagner E; Wittmann HJ; Elz S; Strasser A
Naunyn Schmiedebergs Arch Pharmacol; 2014 Mar; 387(3):235-50. PubMed ID: 24241585
[TBL] [Abstract][Full Text] [Related]
19. Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.
Altenbach RJ; Adair RM; Bettencourt BM; Black LA; Fix-Stenzel SR; Gopalakrishnan SM; Hsieh GC; Liu H; Marsh KC; McPherson MJ; Milicic I; Miller TR; Vortherms TA; Warrior U; Wetter JM; Wishart N; Witte DG; Honore P; Esbenshade TA; Hancock AA; Brioni JD; Cowart MD
J Med Chem; 2008 Oct; 51(20):6571-80. PubMed ID: 18811133
[TBL] [Abstract][Full Text] [Related]
20. Stereochemical diversity-oriented conformational restriction strategy. Development of potent histamine H3 and/or H4 receptor antagonists with an imidazolylcyclopropane structure.
Watanabe M; Kazuta Y; Hayashi H; Yamada S; Matsuda A; Shuto S
J Med Chem; 2006 Sep; 49(18):5587-96. PubMed ID: 16942032
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
