These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

81 related articles for article (PubMed ID: 20024152)

  • 1. Stereoselective synthesis and structure-affinity relationships of bicyclic kappa receptor agonists.
    Kracht D; Rack E; Schepmann D; Fröhlich R; Wünsch B
    Org Biomol Chem; 2010 Jan; 8(1):212-25. PubMed ID: 20024152
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis of 7,9-diazabicyclo[4.2.2]decanes as conformationally restricted κ receptor agonists: fine tuning of the dihedral angle of the ethylenediamine pharmacophore.
    Sunnam SK; Rack E; Schepmann D; Wünsch B
    Eur J Med Chem; 2011 Jun; 46(6):1972-82. PubMed ID: 21481987
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives.
    Geiger C; Zelenka C; Lehmkuhl K; Schepmann D; Englberger W; Wünsch B
    J Med Chem; 2010 May; 53(10):4212-22. PubMed ID: 20441176
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as highly potent kappa-receptor agonists: stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functional studies.
    Soukara S; Maier CA; Predoiu U; Ehret A; Jackisch R; Wünsch B
    J Med Chem; 2001 Aug; 44(17):2814-26. PubMed ID: 11495592
    [TBL] [Abstract][Full Text] [Related]  

  • 5. kappa-Opioid activity of the four stereoisomers of the peripherally selective kappa-agonists, EMD 60,400 and EMD 61,753.
    Gottschlich R; Krug M; Barber A; Devant RM
    Chirality; 1994; 6(8):685-9. PubMed ID: 7857777
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors.
    Cappelli A; Anzini M; Vomero S; Menziani MC; De Benedetti PG; Sbacchi M; Clarke GD; Mennuni L
    J Med Chem; 1996 Feb; 39(4):860-72. PubMed ID: 8632410
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines.
    Molenveld P; Bouzanne des Mazery R; Sterk GJ; Storcken RP; Autar R; van Oss B; van der Haas RN; Fröhlich R; Schepmann D; Wünsch B; Soeberdt M
    Bioorg Med Chem Lett; 2015 Nov; 25(22):5326-30. PubMed ID: 26411794
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis of 8-aminomorphans with high KOR affinity.
    Jonas H; Aiello D; Schepmann D; Diana P; Wünsch B
    Eur J Med Chem; 2022 Feb; 230():114079. PubMed ID: 35033825
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 2. Conformational constraint in the "address" sequence.
    Arttamangkul S; Ishmael JE; Murray TF; Grandy DK; DeLander GE; Kieffer BL; Aldrich JV
    J Med Chem; 1997 Apr; 40(8):1211-8. PubMed ID: 9111295
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biological evaluation of conformationally restricted σ(1) receptor ligands with 7,9-diazabicyclo[4.2.2]decane scaffold.
    Sunnam SK; Schepmann D; Rack E; Fröhlich R; Korpis K; Bednarski PJ; Wünsch B
    Org Biomol Chem; 2010 Dec; 8(24):5525-40. PubMed ID: 20953473
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.
    Katsura Y; Zhang X; Homma K; Rice KC; Calderon SN; Rothman RB; Yamamura HI; Davis P; Flippen-Anderson JL; Xu H; Becketts K; Foltz EJ; Porreca F
    J Med Chem; 1997 Aug; 40(18):2936-47. PubMed ID: 9288176
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and evaluation of novel peripherally restricted kappa-opioid receptor agonists.
    Kumar V; Guo D; Cassel JA; Daubert JD; Dehaven RN; Dehaven-Hudkins DL; Gauntner EK; Gottshall SL; Greiner SL; Koblish M; Little PJ; Mansson E; Maycock AL
    Bioorg Med Chem Lett; 2005 Feb; 15(4):1091-5. PubMed ID: 15686919
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.
    Anzini M; Canullo L; Braile C; Cappelli A; Gallelli A; Vomero S; Menziani MC; De Benedetti PG; Rizzo M; Collina S; Azzolina O; Sbacchi M; Ghelardini C; Galeotti N
    J Med Chem; 2003 Aug; 46(18):3853-64. PubMed ID: 12930147
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Combination of cyclohexane and piperazine based κ-opioid receptor agonists: Synthesis and pharmacological evaluation of trans,trans-configured perhydroquinoxalines.
    Bourgeois C; Werfel E; Schepmann D; Wünsch B
    Bioorg Med Chem; 2014 Jul; 22(13):3316-24. PubMed ID: 24856182
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists.
    Kitbunnadaj R; Zuiderveld OP; De Esch IJ; Vollinga RC; Bakker R; Lutz M; Spek AL; Cavoy E; Deltent MF; Menge WM; Timmerman H; Leurs R
    J Med Chem; 2003 Dec; 46(25):5445-57. PubMed ID: 14640553
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and stereoselective kappa-receptor binding of methylated analogues of GR-89.696.
    Röhr C; Soukara S; Wünsch B
    Eur J Med Chem; 2001 Feb; 36(2):211-4. PubMed ID: 11311752
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dynorphin A analogs containing a conformationally constrained phenylalanine derivative in position 4: reversal of preferred stereochemistry for opioid receptor affinity and discrimination of kappa vs. delta receptors.
    Aldrich JV; Zheng QI; Murray TF
    Chirality; 2001; 13(3):125-9. PubMed ID: 11270320
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Establishment of kappa opioid receptor agonists pharmacophore with molecular modeling method.
    Liu DX; Tang Y; Jiang HL; Chen KX; Ji RY
    Zhongguo Yao Li Xue Bao; 1998 Sep; 19(5):445-50. PubMed ID: 10375807
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors.
    Zhang A; Xiong W; Bidlack JM; Hilbert JE; Knapp BI; Wentland MP; Neumeyer JL
    J Med Chem; 2004 Jan; 47(1):165-74. PubMed ID: 14695830
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The peripherally acting kappa-opiate agonist EMD 61753 and analogues: opioid activity versus peripheral selectivity.
    Gottschlich R; Barber A; Bartoszyk GD; Seyfried CA
    Drugs Exp Clin Res; 1995; 21(5):171-4. PubMed ID: 8846746
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.