BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

265 related articles for article (PubMed ID: 20047143)

  • 1. hERG: protein trafficking and potential for therapy and drug side effects.
    Staudacher I; Schweizer PA; Katus HA; Thomas D
    Curr Opin Drug Discov Devel; 2010 Jan; 13(1):23-30. PubMed ID: 20047143
    [TBL] [Abstract][Full Text] [Related]  

  • 2. [Progress in research on defective protein trafficking and functional restoration in HERG-associated long QT syndrome].
    Fang P; Lian J
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2016 Feb; 33(1):101-4. PubMed ID: 26829745
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development.
    Redfern WS; Carlsson L; Davis AS; Lynch WG; MacKenzie I; Palethorpe S; Siegl PK; Strang I; Sullivan AT; Wallis R; Camm AJ; Hammond TG
    Cardiovasc Res; 2003 Apr; 58(1):32-45. PubMed ID: 12667944
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications.
    Thomas D; Karle CA; Kiehn J
    Curr Pharm Des; 2006; 12(18):2271-83. PubMed ID: 16787254
    [TBL] [Abstract][Full Text] [Related]  

  • 5. hERG-related drug toxicity and models for predicting hERG liability and QT prolongation.
    Raschi E; Ceccarini L; De Ponti F; Recanatini M
    Expert Opin Drug Metab Toxicol; 2009 Sep; 5(9):1005-21. PubMed ID: 19572824
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A history of the role of the hERG channel in cardiac risk assessment.
    Rampe D; Brown AM
    J Pharmacol Toxicol Methods; 2013; 68(1):13-22. PubMed ID: 23538024
    [TBL] [Abstract][Full Text] [Related]  

  • 7. hERG trafficking inhibition in drug-induced lethal cardiac arrhythmia.
    Nogawa H; Kawai T
    Eur J Pharmacol; 2014 Oct; 741():336-9. PubMed ID: 24998878
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Acquired QT interval prolongation and HERG: implications for drug discovery and development.
    Finlayson K; Witchel HJ; McCulloch J; Sharkey J
    Eur J Pharmacol; 2004 Oct; 500(1-3):129-42. PubMed ID: 15464027
    [TBL] [Abstract][Full Text] [Related]  

  • 9. hERG channel trafficking: novel targets in drug-induced long QT syndrome.
    Dennis A; Wang L; Wan X; Ficker E
    Biochem Soc Trans; 2007 Nov; 35(Pt 5):1060-3. PubMed ID: 17956279
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanisms of drug induced QT interval prolongation.
    Ponte ML; Keller GA; Di Girolamo G
    Curr Drug Saf; 2010 Jan; 5(1):44-53. PubMed ID: 20210718
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends.
    Hoffmann P; Warner B
    J Pharmacol Toxicol Methods; 2006; 53(2):87-105. PubMed ID: 16289936
    [TBL] [Abstract][Full Text] [Related]  

  • 12. QT interval prolongation and cardiac risk assessment for novel drugs.
    Picard S; Lacroix P
    Curr Opin Investig Drugs; 2003 Mar; 4(3):303-8. PubMed ID: 12735231
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Fluconazole inhibits hERG K(+) channel by direct block and disruption of protein trafficking.
    Han S; Zhang Y; Chen Q; Duan Y; Zheng T; Hu X; Zhang Z; Zhang L
    Eur J Pharmacol; 2011 Jan; 650(1):138-44. PubMed ID: 20951697
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A place for high-throughput electrophysiology in cardiac safety: screening hERG cell lines and novel compounds with the ion works HTTM system.
    Guthrie H; Livingston FS; Gubler U; Garippa R
    J Biomol Screen; 2005 Dec; 10(8):832-40. PubMed ID: 16234341
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties.
    Polak S; Wiśniowska B; Brandys J
    J Appl Toxicol; 2009 Apr; 29(3):183-206. PubMed ID: 18988205
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Drug-induced hERG block and long QT syndrome.
    Witchel HJ
    Cardiovasc Ther; 2011 Aug; 29(4):251-9. PubMed ID: 20406244
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The effects of a novel anti-arrhythmic drug, acehytisine hydrochloride, on the human ether-a-go-go related gene K channel and its trafficking.
    Huang X; Yang Y; Zhu J; Dai Y; Pu J
    Basic Clin Pharmacol Toxicol; 2009 Feb; 104(2):145-54. PubMed ID: 19143746
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Drug-induced QT interval prolongation--regulatory guidance and perspectives on hERG channel studies.
    Shah RR
    Novartis Found Symp; 2005; 266():251-80; discussion 280-5. PubMed ID: 16050273
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?
    Lu HR; Hermans AN; Gallacher DJ
    Br J Pharmacol; 2012 Jun; 166(4):1490-502. PubMed ID: 22300168
    [TBL] [Abstract][Full Text] [Related]  

  • 20. BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart.
    Qu Y; Fang M; Gao B; Chui RW; Vargas HM
    J Pharmacol Exp Ther; 2011 Apr; 337(1):2-8. PubMed ID: 21205913
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.