183 related articles for article (PubMed ID: 20050843)
1. Active-site concentrations of chemicals - are they a better predictor of effect than plasma/organ/tissue concentrations?
Hammarlund-Udenaes M
Basic Clin Pharmacol Toxicol; 2010 Mar; 106(3):215-20. PubMed ID: 20050843
[TBL] [Abstract][Full Text] [Related]
2. Brain distribution of cetirizine enantiomers: comparison of three different tissue-to-plasma partition coefficients: K(p), K(p,u), and K(p,uu).
Gupta A; Chatelain P; Massingham R; Jonsson EN; Hammarlund-Udenaes M
Drug Metab Dispos; 2006 Feb; 34(2):318-23. PubMed ID: 16303872
[TBL] [Abstract][Full Text] [Related]
3. Blood-brain barrier transport helps to explain discrepancies in in vivo potency between oxycodone and morphine.
Boström E; Hammarlund-Udenaes M; Simonsson US
Anesthesiology; 2008 Mar; 108(3):495-505. PubMed ID: 18292687
[TBL] [Abstract][Full Text] [Related]
4. In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms.
Chen H; Winiwarter S; Fridén M; Antonsson M; Engkvist O
J Mol Graph Model; 2011 Aug; 29(8):985-95. PubMed ID: 21571561
[TBL] [Abstract][Full Text] [Related]
5. In vivo blood-brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics.
Boström E; Simonsson US; Hammarlund-Udenaes M
Drug Metab Dispos; 2006 Sep; 34(9):1624-31. PubMed ID: 16763013
[TBL] [Abstract][Full Text] [Related]
6. Cerebral uptake of drugs in humans.
Upton RN
Clin Exp Pharmacol Physiol; 2007 Aug; 34(8):695-701. PubMed ID: 17600543
[TBL] [Abstract][Full Text] [Related]
7. Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice.
Maurer TS; Debartolo DB; Tess DA; Scott DO
Drug Metab Dispos; 2005 Jan; 33(1):175-81. PubMed ID: 15502010
[TBL] [Abstract][Full Text] [Related]
8. Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.
Fridén M; Winiwarter S; Jerndal G; Bengtsson O; Wan H; Bredberg U; Hammarlund-Udenaes M; Antonsson M
J Med Chem; 2009 Oct; 52(20):6233-43. PubMed ID: 19764786
[TBL] [Abstract][Full Text] [Related]
9. Progress in brain penetration evaluation in drug discovery and development.
Liu X; Chen C; Smith BJ
J Pharmacol Exp Ther; 2008 May; 325(2):349-56. PubMed ID: 18203948
[TBL] [Abstract][Full Text] [Related]
10. [Blood plasma proteins and drug transport across the hemato-encephalic barrier].
Lutsevich AN; Bender KI; Kupchikov VV
Farmakol Toksikol; 1991; 54(1):70-6. PubMed ID: 1860509
[TBL] [Abstract][Full Text] [Related]
11. Use of unbound volumes of drug distribution in pharmacokinetic calculations.
Stepensky D
Eur J Pharm Sci; 2011 Jan; 42(1-2):91-8. PubMed ID: 21050885
[TBL] [Abstract][Full Text] [Related]
12. PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation.
Caruso A; Alvarez-Sánchez R; Hillebrecht A; Poirier A; Schuler F; Lavé T; Funk C; Belli S
Biochem Pharmacol; 2013 Jun; 85(11):1684-99. PubMed ID: 23454189
[TBL] [Abstract][Full Text] [Related]
13. Potential of solid lipid nanoparticles in brain targeting.
Kaur IP; Bhandari R; Bhandari S; Kakkar V
J Control Release; 2008 Apr; 127(2):97-109. PubMed ID: 18313785
[TBL] [Abstract][Full Text] [Related]
14. Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: possible involvement of the monocarboxylic acid transport system.
Deguchi Y; Nozawa K; Yamada S; Yokoyama Y; Kimura R
J Pharmacol Exp Ther; 1997 Feb; 280(2):551-60. PubMed ID: 9023263
[TBL] [Abstract][Full Text] [Related]
15. Prediction of antiepileptic drug efficacy: the use of intracerebral microdialysis to monitor biophase concentrations.
Clinckers R; Smolders I; Vermoesen K; Michotte Y; Danhof M; Voskuyl R; Della Pasqua O
Expert Opin Drug Metab Toxicol; 2009 Oct; 5(10):1267-77. PubMed ID: 19611404
[TBL] [Abstract][Full Text] [Related]
16. Comparing translational population-PBPK modelling of brain microdialysis with bottom-up prediction of brain-to-plasma distribution in rat and human.
Ball K; Bouzom F; Scherrmann JM; Walther B; Declèves X
Biopharm Drug Dispos; 2014 Nov; 35(8):485-99. PubMed ID: 25044007
[TBL] [Abstract][Full Text] [Related]
17. Central nervous system distribution kinetics of indinavir in rats.
Hamidi M
J Pharm Pharmacol; 2007 Aug; 59(8):1077-85. PubMed ID: 17725849
[TBL] [Abstract][Full Text] [Related]
18. Unbound brain concentration determines receptor occupancy: a correlation of drug concentration and brain serotonin and dopamine reuptake transporter occupancy for eighteen compounds in rats.
Liu X; Vilenski O; Kwan J; Apparsundaram S; Weikert R
Drug Metab Dispos; 2009 Jul; 37(7):1548-56. PubMed ID: 19389861
[TBL] [Abstract][Full Text] [Related]
19. Blood-brain barrier transport of morphine in patients with severe brain trauma.
Ederoth P; Tunblad K; Bouw R; Lundberg CJ; Ungerstedt U; Nordström CH; Hammarlund-Udenaes M
Br J Clin Pharmacol; 2004 Apr; 57(4):427-35. PubMed ID: 15025740
[TBL] [Abstract][Full Text] [Related]
20. Confounding parameters in preclinical assessment of blood-brain barrier permeation: an overview with emphasis on species differences and effect of disease states.
Deo AK; Theil FP; Nicolas JM
Mol Pharm; 2013 May; 10(5):1581-95. PubMed ID: 23256608
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
