BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

283 related articles for article (PubMed ID: 20053681)

  • 1. Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1.
    Gagou ME; Zuazua-Villar P; Meuth M
    Mol Biol Cell; 2010 Mar; 21(5):739-52. PubMed ID: 20053681
    [TBL] [Abstract][Full Text] [Related]  

  • 2. ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.
    Myers K; Gagou ME; Zuazua-Villar P; Rodriguez R; Meuth M
    PLoS Genet; 2009 Jan; 5(1):e1000324. PubMed ID: 19119425
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45.
    Rodriguez R; Gagou ME; Meuth M
    Cell Death Differ; 2008 May; 15(5):889-98. PubMed ID: 18239674
    [TBL] [Abstract][Full Text] [Related]  

  • 4. H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation.
    Ewald B; Sampath D; Plunkett W
    Mol Cancer Ther; 2007 Apr; 6(4):1239-48. PubMed ID: 17406032
    [TBL] [Abstract][Full Text] [Related]  

  • 5. DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B.
    Zuazua-Villar P; Rodriguez R; Gagou ME; Eyers PA; Meuth M
    Cell Death Dis; 2014 May; 5(5):e1253. PubMed ID: 24853431
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents.
    Liu JS; Kuo SR; Melendy T
    Mutat Res; 2003 Nov; 532(1-2):215-26. PubMed ID: 14643438
    [TBL] [Abstract][Full Text] [Related]  

  • 7. UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
    Sun J; Zhu Z; Li W; Shen M; Cao C; Sun Q; Guo Z; Liu L; Wu D
    J Exp Clin Cancer Res; 2020 Oct; 39(1):222. PubMed ID: 33087136
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis.
    Kurose A; Tanaka T; Huang X; Halicka HD; Traganos F; Dai W; Darzynkiewicz Z
    Cytometry A; 2005 Nov; 68(1):1-9. PubMed ID: 16184611
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage.
    Ha K; Fiskus W; Rao R; Balusu R; Venkannagari S; Nalabothula NR; Bhalla KN
    Mol Cancer Ther; 2011 Jul; 10(7):1194-206. PubMed ID: 21566061
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response.
    Maude SL; Enders GH
    Cancer Res; 2005 Feb; 65(3):780-6. PubMed ID: 15705874
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
    Furuta T; Takemura H; Liao ZY; Aune GJ; Redon C; Sedelnikova OA; Pilch DR; Rogakou EP; Celeste A; Chen HT; Nussenzweig A; Aladjem MI; Bonner WM; Pommier Y
    J Biol Chem; 2003 May; 278(22):20303-12. PubMed ID: 12660252
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Histone H2AX phosphorylation after cell irradiation with UV-B: relationship to cell cycle phase and induction of apoptosis.
    Halicka HD; Huang X; Traganos F; King MA; Dai W; Darzynkiewicz Z
    Cell Cycle; 2005 Feb; 4(2):339-45. PubMed ID: 15655354
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hedamycin, a DNA alkylator, induces (gamma)H2AX and chromosome aberrations: involvement of phosphatidylinositol 3-kinase-related kinases and DNA replication fork movement.
    Tu LC; Matsui SI; Beerman TA
    Mol Cancer Ther; 2005 Aug; 4(8):1175-85. PubMed ID: 16093433
    [TBL] [Abstract][Full Text] [Related]  

  • 14. MDC1 is a mediator of the mammalian DNA damage checkpoint.
    Stewart GS; Wang B; Bignell CR; Taylor AM; Elledge SJ
    Nature; 2003 Feb; 421(6926):961-6. PubMed ID: 12607005
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase.
    Wayne J; Brooks T; Massey AJ
    Oncotarget; 2016 Dec; 7(51):85033-85048. PubMed ID: 27829224
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.
    Syljuåsen RG; Sørensen CS; Hansen LT; Fugger K; Lundin C; Johansson F; Helleday T; Sehested M; Lukas J; Bartek J
    Mol Cell Biol; 2005 May; 25(9):3553-62. PubMed ID: 15831461
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase.
    Tanaka T; Halicka HD; Traganos F; Seiter K; Darzynkiewicz Z
    Cell Cycle; 2007 Feb; 6(3):371-6. PubMed ID: 17297310
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress.
    Rodriguez R; Meuth M
    Mol Biol Cell; 2006 Jan; 17(1):402-12. PubMed ID: 16280359
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis.
    Pan Y; Ren KH; He HW; Shao RG
    Cancer Biol Ther; 2009 Aug; 8(16):1559-66. PubMed ID: 19502782
    [TBL] [Abstract][Full Text] [Related]  

  • 20. H2AX is required for cell cycle arrest via the p53/p21 pathway.
    Fragkos M; Jurvansuu J; Beard P
    Mol Cell Biol; 2009 May; 29(10):2828-40. PubMed ID: 19273588
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.