BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

203 related articles for article (PubMed ID: 20064975)

  • 1. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.
    Groth C; Alvord WG; Quiñones OA; Fortini ME
    Mol Pharmacol; 2010 Apr; 77(4):567-74. PubMed ID: 20064975
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.
    Yang T; Arslanova D; Gu Y; Augelli-Szafran C; Xia W
    Mol Brain; 2008 Nov; 1():15. PubMed ID: 18983676
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.
    Lewis HD; Pérez Revuelta BI; Nadin A; Neduvelil JG; Harrison T; Pollack SJ; Shearman MS
    Biochemistry; 2003 Jun; 42(24):7580-6. PubMed ID: 12809514
    [TBL] [Abstract][Full Text] [Related]  

  • 4. An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.
    Sala Frigerio C; Kukar TL; Fauq A; Engel PC; Golde TE; Walsh DM
    Biochemistry; 2009 Nov; 48(46):10894-904. PubMed ID: 19821615
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila.
    Alattia JR; Kuraishi T; Dimitrov M; Chang I; Lemaitre B; Fraering PC
    FASEB J; 2011 Jul; 25(7):2287-95. PubMed ID: 21415381
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A sensitive and quantitative assay for measuring cleavage of presenilin substrates.
    Karlström H; Bergman A; Lendahl U; Näslund J; Lundkvist J
    J Biol Chem; 2002 Mar; 277(9):6763-6. PubMed ID: 11744687
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.
    Micchelli CA; Esler WP; Kimberly WT; Jack C; Berezovska O; Kornilova A; Hyman BT; Perrimon N; Wolfe MS
    FASEB J; 2003 Jan; 17(1):79-81. PubMed ID: 12424225
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.
    Roncarati R; Sestan N; Scheinfeld MH; Berechid BE; Lopez PA; Meucci O; McGlade JC; Rakic P; D'Adamio L
    Proc Natl Acad Sci U S A; 2002 May; 99(10):7102-7. PubMed ID: 12011466
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Gamma-secretase: substrates and inhibitors.
    Rochette MJ; Murphy MP
    Mol Neurobiol; 2002 Aug; 26(1):81-95. PubMed ID: 12392058
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 11. γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease.
    Nakayama K; Nagase H; Koh CS; Ohkawara T
    Cell Mol Neurobiol; 2011 Aug; 31(6):887-900. PubMed ID: 21516353
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
    Stempfle D; Kanwar R; Loewer A; Fortini ME; Merdes G
    Mol Cell Biol; 2010 Jul; 30(13):3165-75. PubMed ID: 20421416
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
    Kimberly WT; Esler WP; Ye W; Ostaszewski BL; Gao J; Diehl T; Selkoe DJ; Wolfe MS
    Biochemistry; 2003 Jan; 42(1):137-44. PubMed ID: 12515548
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct.
    Tarassishin L; Yin YI; Bassit B; Li YM
    Proc Natl Acad Sci U S A; 2004 Dec; 101(49):17050-5. PubMed ID: 15563588
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Activity of gamma-secretase on substrates other than APP.
    Lleó A
    Curr Top Med Chem; 2008; 8(1):9-16. PubMed ID: 18220928
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Verteporfin is a substrate-selective γ-secretase inhibitor that binds the amyloid precursor protein transmembrane domain.
    Castro MA; Parson KF; Beg I; Wilkinson MC; Nurmakova K; Levesque I; Voehler MW; Wolfe MS; Ruotolo BT; Sanders CR
    J Biol Chem; 2022 Apr; 298(4):101792. PubMed ID: 35247387
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.
    Barten DM; Guss VL; Corsa JA; Loo A; Hansel SB; Zheng M; Munoz B; Srinivasan K; Wang B; Robertson BJ; Polson CT; Wang J; Roberts SB; Hendrick JP; Anderson JJ; Loy JK; Denton R; Verdoorn TA; Smith DW; Felsenstein KM
    J Pharmacol Exp Ther; 2005 Feb; 312(2):635-43. PubMed ID: 15452193
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
    Steiner H; Winkler E; Shearman MS; Prywes R; Haass C
    Neurobiol Dis; 2001 Aug; 8(4):717-22. PubMed ID: 11493036
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells.
    Liao YF; Wang BJ; Hsu WM; Lee H; Liao CY; Wu SY; Cheng HT; Hu MK
    Mol Pharmacol; 2007 Feb; 71(2):588-601. PubMed ID: 17105873
    [TBL] [Abstract][Full Text] [Related]  

  • 20. X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.
    King GD; Cherian K; Turner RS
    J Neurochem; 2004 Feb; 88(4):971-82. PubMed ID: 14756819
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.