107 related articles for article (PubMed ID: 20066278)
1. Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent.
Maroz A; Shinde SS; Franzblau SG; Ma Z; Denny WA; Palmer BD; Anderson RF
Org Biomol Chem; 2010 Jan; 8(2):413-8. PubMed ID: 20066278
[TBL] [Abstract][Full Text] [Related]
2. The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824.
Bollo S; Núñez-Vergara LJ; Kang S; Zhang L; Boshoff HI; Barry CE; Squella JA; Dowd CS
Bioorg Med Chem Lett; 2011 Jan; 21(2):812-7. PubMed ID: 21168331
[TBL] [Abstract][Full Text] [Related]
3. Intermediates in the reduction of the antituberculosis drug PA-824, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, in aqueous solution.
Anderson RF; Shinde SS; Maroz A; Boyd M; Palmer BD; Denny WA
Org Biomol Chem; 2008 Jun; 6(11):1973-80. PubMed ID: 18480913
[TBL] [Abstract][Full Text] [Related]
4. Synthesis, reduction potentials, and antitubercular activity of ring A/B analogues of the bioreductive drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Thompson AM; Blaser A; Anderson RF; Shinde SS; Franzblau SG; Ma Z; Denny WA; Palmer BD
J Med Chem; 2009 Feb; 52(3):637-45. PubMed ID: 19099398
[TBL] [Abstract][Full Text] [Related]
5. Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles.
Kim P; Zhang L; Manjunatha UH; Singh R; Patel S; Jiricek J; Keller TH; Boshoff HI; Barry CE; Dowd CS
J Med Chem; 2009 Mar; 52(5):1317-28. PubMed ID: 19209889
[TBL] [Abstract][Full Text] [Related]
6. Bactericidal activity of PA-824 against Mycobacterium tuberculosis under anaerobic conditions and computational analysis of its novel analogues against mutant Ddn receptor.
Somasundaram S; Anand RS; Venkatesan P; Paramasivan CN
BMC Microbiol; 2013 Oct; 13():218. PubMed ID: 24083570
[TBL] [Abstract][Full Text] [Related]
7. The nitroimidazooxazines (PA-824 and analogs): structure-activity relationship and mechanistic studies.
Denny WA; Palmer BD
Future Med Chem; 2010 Aug; 2(8):1295-304. PubMed ID: 21426020
[TBL] [Abstract][Full Text] [Related]
8. Pharmacophore modeling and density functional theory analysis for a series of nitroimidazole compounds with antitubercular activity.
Tawari NR; Degani MS
Chem Biol Drug Des; 2011 Sep; 78(3):408-17. PubMed ID: 21689377
[TBL] [Abstract][Full Text] [Related]
9. PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.
Singh R; Manjunatha U; Boshoff HI; Ha YH; Niyomrattanakit P; Ledwidge R; Dowd CS; Lee IY; Kim P; Zhang L; Kang S; Keller TH; Jiricek J; Barry CE
Science; 2008 Nov; 322(5906):1392-5. PubMed ID: 19039139
[TBL] [Abstract][Full Text] [Related]
10. Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.
Kim P; Kang S; Boshoff HI; Jiricek J; Collins M; Singh R; Manjunatha UH; Niyomrattanakit P; Zhang L; Goodwin M; Dick T; Keller TH; Dowd CS; Barry CE
J Med Chem; 2009 Mar; 52(5):1329-44. PubMed ID: 19209893
[TBL] [Abstract][Full Text] [Related]
11. Biarylmethoxy 2-nitroimidazooxazine antituberculosis agents: Effects of proximal ring substitution and linker reversal on metabolism and efficacy.
Thompson AM; Blaser A; Palmer BD; Franzblau SG; Wan B; Wang Y; Ma Z; Denny WA
Bioorg Med Chem Lett; 2015 Sep; 25(18):3804-9. PubMed ID: 26253632
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Palmer BD; Thompson AM; Sutherland HS; Blaser A; Kmentova I; Franzblau SG; Wan B; Wang Y; Ma Z; Denny WA
J Med Chem; 2010 Jan; 53(1):282-94. PubMed ID: 19928920
[TBL] [Abstract][Full Text] [Related]
13. Alkylated/aminated nitroimidazoles and nitroimidazole-7-chloroquinoline conjugates: Synthesis and anti-mycobacterial evaluation.
Shalini ; Viljoen A; Kremer L; Kumar V
Bioorg Med Chem Lett; 2018 May; 28(8):1309-1312. PubMed ID: 29551480
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and anti-tubercular activity of 2-nitroimidazooxazines with modification at the C-7 position as PA-824 analogs.
Kang YG; Park CY; Shin H; Singh R; Arora G; Yu CM; Lee IY
Bioorg Med Chem Lett; 2015 Sep; 25(17):3650-3. PubMed ID: 26199118
[TBL] [Abstract][Full Text] [Related]
15. Synthesis, structure and biological evaluation of novel bicyclic nitroimidazole derivatives.
Zaprutko L; Zwawiak J; Augustynowicz-Kopeć E; Zwolska Z; Bartoszak-Adamska E; Nowicki W
Arch Pharm (Weinheim); 2012 Jun; 345(6):463-7. PubMed ID: 22266946
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids.
Rakesh ; Bruhn DF; Scherman MS; Singh AP; Yang L; Liu J; Lenaerts AJ; Lee RE
Bioorg Med Chem Lett; 2016 Jan; 26(2):388-391. PubMed ID: 26711150
[TBL] [Abstract][Full Text] [Related]
17. Mechanism of action of 5-nitrothiophenes against Mycobacterium tuberculosis.
Hartkoorn RC; Ryabova OB; Chiarelli LR; Riccardi G; Makarov V; Cole ST
Antimicrob Agents Chemother; 2014 May; 58(5):2944-7. PubMed ID: 24550336
[TBL] [Abstract][Full Text] [Related]
18. Comparative bioactivation of the novel anti-tuberculosis agent PA-824 in Mycobacteria and a subcellular fraction of human liver.
Dogra M; Palmer BD; Bashiri G; Tingle MD; Shinde SS; Anderson RF; O'Toole R; Baker EN; Denny WA; Helsby NA
Br J Pharmacol; 2011 Jan; 162(1):226-36. PubMed ID: 20955364
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents.
Mugunthan G; Sriram D; Yogeeswari P; Ravindranathan Kartha KP
Carbohydr Res; 2011 Sep; 346(13):1760-6. PubMed ID: 21714959
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and structure-activity relationships for extended side chain analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Palmer BD; Sutherland HS; Blaser A; Kmentova I; Franzblau SG; Wan B; Wang Y; Ma Z; Denny WA; Thompson AM
J Med Chem; 2015 Apr; 58(7):3036-59. PubMed ID: 25781074
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
