BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

251 related articles for article (PubMed ID: 20067769)

  • 1. Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints.
    Sabisz M; Wesierska-Gadek J; Skladanowski A
    Biochem Pharmacol; 2010 May; 79(10):1387-97. PubMed ID: 20067769
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Poly(ADPR)polymerase-1 signalling of the DNA damage induced by DNA topoisomerase I poison in D54(p53wt) and U251(p53mut) glioblastoma cell lines.
    Cimmino G; Pepe S; Laus G; Chianese M; Prece D; Penitente R; Quesada P
    Pharmacol Res; 2007 Jan; 55(1):49-56. PubMed ID: 17127074
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest.
    Wesierska-Gadek J; Schloffer D; Gueorguieva M; Uhl M; Skladanowski A
    Cancer Res; 2004 Jul; 64(13):4487-97. PubMed ID: 15231658
    [TBL] [Abstract][Full Text] [Related]  

  • 4. PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells.
    Węsierska-Gądek J; Zulehner N; Ferk F; Składanowski A; Komina O; Maurer M
    Biochem Pharmacol; 2012 Nov; 84(10):1318-31. PubMed ID: 22906755
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro.
    Bowman KJ; Newell DR; Calvert AH; Curtin NJ
    Br J Cancer; 2001 Jan; 84(1):106-12. PubMed ID: 11139322
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effect of p53 activity on the sensitivity of human glioblastoma cells to PARP-1 inhibitor in combination with topoisomerase I inhibitor or radiation.
    Sabbatino F; Fusciello C; Somma D; Pacelli R; Poudel R; Pepin D; Leonardi A; Carlomagno C; Della Vittoria Scarpati G; Ferrone S; Pepe S
    Cytometry A; 2014 Nov; 85(11):953-61. PubMed ID: 25182801
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.
    Bowman KJ; White A; Golding BT; Griffin RJ; Curtin NJ
    Br J Cancer; 1998 Nov; 78(10):1269-77. PubMed ID: 9823965
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells.
    Okuda A; Kurokawa S; Takehashi M; Maeda A; Fukuda K; Kubo Y; Nogusa H; Takatani-Nakase T; Okuda S; Ueda K; Tanaka S
    BMC Neurosci; 2017 Jan; 18(1):14. PubMed ID: 28095779
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Differential Potential of Pharmacological PARP Inhibitors for Inhibiting Cell Proliferation and Inducing Apoptosis in Human Breast Cancer Cells.
    Węsierska-Gądek J; Mauritz M; Mitulovic G; Cupo M
    J Cell Biochem; 2015 Dec; 116(12):2824-39. PubMed ID: 25981734
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Poly(ADP-ribose) polymerase signaling of topoisomerase 1-dependent DNA damage in carcinoma cells.
    D'Onofrio G; Tramontano F; Dorio AS; Muzi A; Maselli V; Fulgione D; Graziani G; Malanga M; Quesada P
    Biochem Pharmacol; 2011 Jan; 81(2):194-202. PubMed ID: 20875401
    [TBL] [Abstract][Full Text] [Related]  

  • 11. BubR1 is involved in regulation of DNA damage responses.
    Fang Y; Liu T; Wang X; Yang YM; Deng H; Kunicki J; Traganos F; Darzynkiewicz Z; Lu L; Dai W
    Oncogene; 2006 Jun; 25(25):3598-605. PubMed ID: 16449973
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation.
    Xiao Z; Xue J; Sowin TJ; Rosenberg SH; Zhang H
    Oncogene; 2005 Feb; 24(8):1403-11. PubMed ID: 15608676
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe.
    Tse AN; Schwartz GK
    Cancer Res; 2004 Sep; 64(18):6635-44. PubMed ID: 15374978
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage.
    Nabha SM; Mohammad RM; Dandashi MH; Coupaye-Gerard B; Aboukameel A; Pettit GR; Al-Katib AM
    Clin Cancer Res; 2002 Aug; 8(8):2735-41. PubMed ID: 12171907
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Treatment with the PARP-inhibitor PJ34 causes enhanced doxorubicin-mediated cell death in HeLa cells.
    Magan N; Isaacs RJ; Stowell KM
    Anticancer Drugs; 2012 Jul; 23(6):627-37. PubMed ID: 22293659
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest.
    Madison DL; Stauffer D; Lundblad JR
    DNA Repair (Amst); 2011 Oct; 10(10):1003-13. PubMed ID: 21840268
    [TBL] [Abstract][Full Text] [Related]  

  • 17. p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells.
    Montariello D; Troiano A; Malanga M; Calabrò V; Quesada P
    Biochem Pharmacol; 2013 Apr; 85(7):999-1006. PubMed ID: 23376119
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Triazoloacridone C-1305 abrogates the restriction checkpoint in cells lacking functional p53 and promotes their accumulation in the G2/M phase of the cell cycle.
    Maurer M; Komina O; Składanowski A; Wesierska-Gadek J
    J Exp Ther Oncol; 2011; 9(1):5-15. PubMed ID: 21275261
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effect of poly(ADP-ribose)polymerase and DNA topoisomerase I inhibitors on the p53/p63-dependent survival of carcinoma cells.
    Montariello D; Troiano A; Di Girolamo D; Beneke S; Calabrò V; Quesada P
    Biochem Pharmacol; 2015 Apr; 94(3):212-9. PubMed ID: 25667043
    [TBL] [Abstract][Full Text] [Related]  

  • 20. PARP-1 inhibitor sensitizes arsenic trioxide in hepatocellular carcinoma cells via abrogation of G2/M checkpoint and suppression of DNA damage repair.
    Luo Q; Li Y; Deng J; Zhang Z
    Chem Biol Interact; 2015 Jan; 226():12-22. PubMed ID: 25499136
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.