269 related articles for article (PubMed ID: 20080939)
1. Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling.
Almeida MQ; Muchow M; Boikos S; Bauer AJ; Griffin KJ; Tsang KM; Cheadle C; Watkins T; Wen F; Starost MF; Bossis I; Nesterova M; Stratakis CA
Hum Mol Genet; 2010 Apr; 19(8):1387-98. PubMed ID: 20080939
[TBL] [Abstract][Full Text] [Related]
2. Clinical and molecular genetics of Carney complex.
Rothenbuhler A; Stratakis CA
Best Pract Res Clin Endocrinol Metab; 2010 Jun; 24(3):389-99. PubMed ID: 20833331
[TBL] [Abstract][Full Text] [Related]
3. Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors.
Gaujoux S; Tissier F; Groussin L; Libé R; Ragazzon B; Launay P; Audebourg A; Dousset B; Bertagna X; Bertherat J
J Clin Endocrinol Metab; 2008 Oct; 93(10):4135-40. PubMed ID: 18647815
[TBL] [Abstract][Full Text] [Related]
4. Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A.
Pavel E; Nadella K; Towns WH; Kirschner LS
Mol Endocrinol; 2008 Feb; 22(2):430-40. PubMed ID: 17932105
[TBL] [Abstract][Full Text] [Related]
5. In vitro studies of novel PRKAR1A mutants that extend the predicted RIα protein sequence into the 3'-untranslated open reading frame: proteasomal degradation leads to RIα haploinsufficiency and Carney complex.
Patronas Y; Horvath A; Greene E; Tsang K; Bimpaki E; Haran M; Nesterova M; Stratakis CA
J Clin Endocrinol Metab; 2012 Mar; 97(3):E496-502. PubMed ID: 22205709
[TBL] [Abstract][Full Text] [Related]
6. An immortalized human cell line bearing a PRKAR1A-inactivating mutation: effects of overexpression of the wild-type Allele and other protein kinase A subunits.
Nesterova M; Bossis I; Wen F; Horvath A; Matyakhina L; Stratakis CA
J Clin Endocrinol Metab; 2008 Feb; 93(2):565-71. PubMed ID: 18056771
[TBL] [Abstract][Full Text] [Related]
7. Use of mouse models to understand the molecular basis of tissue-specific tumorigenesis in the Carney complex.
Kirschner LS
J Intern Med; 2009 Jul; 266(1):60-8. PubMed ID: 19522826
[TBL] [Abstract][Full Text] [Related]
8. Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations.
Almeida MQ; Azevedo MF; Xekouki P; Bimpaki EI; Horvath A; Collins MT; Karaviti LP; Jeha GS; Bhattacharyya N; Cheadle C; Watkins T; Bourdeau I; Nesterova M; Stratakis CA
J Clin Endocrinol Metab; 2012 Apr; 97(4):E687-93. PubMed ID: 22259056
[TBL] [Abstract][Full Text] [Related]
9. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit (PRKAR1A) in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas" (Carney complex).
Stratakis CA
Ann N Y Acad Sci; 2002 Jun; 968():3-21. PubMed ID: 12119264
[TBL] [Abstract][Full Text] [Related]
10. PRKAR1A mutations in primary pigmented nodular adrenocortical disease.
Cazabat L; Ragazzon B; Groussin L; Bertherat J
Pituitary; 2006; 9(3):211-9. PubMed ID: 17036196
[TBL] [Abstract][Full Text] [Related]
11. Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters.
Cazabat L; Ragazzon B; Varin A; Potier-Cartereau M; Vandier C; Vezzosi D; Risk-Rabin M; Guellich A; Schittl J; Lechêne P; Richter W; Nikolaev VO; Zhang J; Bertherat J; Vandecasteele G
Hum Mol Genet; 2014 Mar; 23(5):1163-74. PubMed ID: 24122441
[TBL] [Abstract][Full Text] [Related]
12. Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice.
Liu S; Saloustros E; Mertz EL; Tsang K; Starost MF; Salpea P; Faucz FR; Szarek E; Nesterova M; Leikin S; Stratakis CA
Hum Mol Genet; 2015 Nov; 24(21):6080-92. PubMed ID: 26246497
[TBL] [Abstract][Full Text] [Related]
13. A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
Griffin KJ; Kirschner LS; Matyakhina L; Stergiopoulos SG; Robinson-White A; Lenherr SM; Weinberg FD; Claflin ES; Batista D; Bourdeau I; Voutetakis A; Sandrini F; Meoli EM; Bauer AJ; Cho-Chung YS; Bornstein SR; Carney JA; Stratakis CA
J Med Genet; 2004 Dec; 41(12):923-31. PubMed ID: 15591278
[TBL] [Abstract][Full Text] [Related]
14. Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation.
Leal LF; Szarek E; Berthon A; Nesterova M; Faucz FR; London E; Mercier C; Abu-Asab M; Starost MF; Dye L; Bilinska B; Kotula-Balak M; Antonini SR; Stratakis CA
Mol Cell Endocrinol; 2021 Feb; 522():111117. PubMed ID: 33338547
[TBL] [Abstract][Full Text] [Related]
15. Loss of expression of protein kinase a regulatory subunit 1alpha in pigmented epithelioid melanocytoma but not in melanoma or other melanocytic lesions.
Zembowicz A; Knoepp SM; Bei T; Stergiopoulos S; Eng C; Mihm MC; Stratakis CA
Am J Surg Pathol; 2007 Nov; 31(11):1764-75. PubMed ID: 18059235
[TBL] [Abstract][Full Text] [Related]
16. The regulatory 1α subunit of protein kinase A modulates renal cystogenesis.
Ye H; Wang X; Constans MM; Sussman CR; Chebib FT; Irazabal MV; Young WF; Harris PC; Kirschner LS; Torres VE
Am J Physiol Renal Physiol; 2017 Sep; 313(3):F677-F686. PubMed ID: 28615245
[TBL] [Abstract][Full Text] [Related]
17. Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells.
Ragazzon B; Cazabat L; Rizk-Rabin M; Assie G; Groussin L; Fierrard H; Perlemoine K; Martinez A; Bertherat J
Cancer Res; 2009 Sep; 69(18):7278-84. PubMed ID: 19738044
[TBL] [Abstract][Full Text] [Related]
18. Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition.
Nadella KS; Jones GN; Trimboli A; Stratakis CA; Leone G; Kirschner LS
Cancer Res; 2008 Apr; 68(8):2671-7. PubMed ID: 18413734
[TBL] [Abstract][Full Text] [Related]
19. Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice.
Veugelers M; Wilkes D; Burton K; McDermott DA; Song Y; Goldstein MM; La Perle K; Vaughan CJ; O'Hagan A; Bennett KR; Meyer BJ; Legius E; Karttunen M; Norio R; Kaariainen H; Lavyne M; Neau JP; Richter G; Kirali K; Farnsworth A; Stapleton K; Morelli P; Takanashi Y; Bamforth JS; Eitelberger F; Noszian I; Manfroi W; Powers J; Mochizuki Y; Imai T; Ko GT; Driscoll DA; Goldmuntz E; Edelberg JM; Collins A; Eccles D; Irvine AD; McKnight GS; Basson CT
Proc Natl Acad Sci U S A; 2004 Sep; 101(39):14222-7. PubMed ID: 15371594
[TBL] [Abstract][Full Text] [Related]
20. Prkar1a gene knockout in the pancreas leads to neuroendocrine tumorigenesis.
Saloustros E; Salpea P; Starost M; Liu S; Faucz FR; London E; Szarek E; Song WJ; Hussain M; Stratakis CA
Endocr Relat Cancer; 2017 Jan; 24(1):31-40. PubMed ID: 27803029
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
