BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

200 related articles for article (PubMed ID: 20088513)

  • 1. Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
    Rose NR; Woon EC; Kingham GL; King ON; Mecinović J; Clifton IJ; Ng SS; Talib-Hardy J; Oppermann U; McDonough MA; Schofield CJ
    J Med Chem; 2010 Feb; 53(4):1810-8. PubMed ID: 20088513
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).
    Sekirnik R; Rose NR; Thalhammer A; Seden PT; Mecinović J; Schofield CJ
    Chem Commun (Camb); 2009 Nov; (42):6376-8. PubMed ID: 19841782
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.
    Thalhammer A; Mecinović J; Loenarz C; Tumber A; Rose NR; Heightman TD; Schofield CJ
    Org Biomol Chem; 2011 Jan; 9(1):127-35. PubMed ID: 21076780
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.
    King ON; Li XS; Sakurai M; Kawamura A; Rose NR; Ng SS; Quinn AM; Rai G; Mott BT; Beswick P; Klose RJ; Oppermann U; Jadhav A; Heightman TD; Maloney DJ; Schofield CJ; Simeonov A
    PLoS One; 2010 Nov; 5(11):e15535. PubMed ID: 21124847
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy.
    Giri NC; Passantino L; Sun H; Zoroddu MA; Costa M; Maroney MJ
    Biochemistry; 2013 Jun; 52(24):4168-83. PubMed ID: 23692052
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases.
    Krishnan S; Trievel RC
    Structure; 2013 Jan; 21(1):98-108. PubMed ID: 23219879
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-function relationships in KDM7 histone demethylases.
    Chaturvedi SS; Ramanan R; Waheed SO; Karabencheva-Christova TG; Christov CZ
    Adv Protein Chem Struct Biol; 2019; 117():113-125. PubMed ID: 31564306
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of JMJD6 by 2-Oxoglutarate Mimics.
    Islam MS; Thinnes CC; Holt-Martyn JP; Chowdhury R; McDonough MA; Schofield CJ
    ChemMedChem; 2022 Jan; 17(1):e202100398. PubMed ID: 34581506
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases.
    Roatsch M; Hoffmann I; Abboud MI; Hancock RL; Tarhonskaya H; Hsu KF; Wilkins SE; Yeh TL; Lippl K; Serrer K; Moneke I; Ahrens TD; Robaa D; Wenzler S; Barthes NPF; Franz H; Sippl W; Lassmann S; Diederichs S; Schleicher E; Schofield CJ; Kawamura A; Schüle R; Jung M
    ACS Chem Biol; 2019 Aug; 14(8):1737-1750. PubMed ID: 31287655
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.
    Yue WW; Hozjan V; Ge W; Loenarz C; Cooper CD; Schofield CJ; Kavanagh KL; Oppermann U; McDonough MA
    FEBS Lett; 2010 Feb; 584(4):825-30. PubMed ID: 20067792
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Studies on substrate specificity of Jmjd2a-c histone demethylases.
    Ponnaluri VK; Vavilala DT; Mukherji M
    Biochem Biophys Res Commun; 2011 Feb; 405(4):588-92. PubMed ID: 21266164
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
    Ng SS; Kavanagh KL; McDonough MA; Butler D; Pilka ES; Lienard BM; Bray JE; Savitsky P; Gileadi O; von Delft F; Rose NR; Offer J; Scheinost JC; Borowski T; Sundstrom M; Schofield CJ; Oppermann U
    Nature; 2007 Jul; 448(7149):87-91. PubMed ID: 17589501
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
    Rose NR; Woon EC; Tumber A; Walport LJ; Chowdhury R; Li XS; King ON; Lejeune C; Ng SS; Krojer T; Chan MC; Rydzik AM; Hopkinson RJ; Che KH; Daniel M; Strain-Damerell C; Gileadi C; Kochan G; Leung IK; Dunford J; Yeoh KK; Ratcliffe PJ; Burgess-Brown N; von Delft F; Muller S; Marsden B; Brennan PE; McDonough MA; Oppermann U; Klose RJ; Schofield CJ; Kawamura A
    J Med Chem; 2012 Jul; 55(14):6639-43. PubMed ID: 22724510
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.
    Westaway SM; Preston AG; Barker MD; Brown F; Brown JA; Campbell M; Chung CW; Drewes G; Eagle R; Garton N; Gordon L; Haslam C; Hayhow TG; Humphreys PG; Joberty G; Katso R; Kruidenier L; Leveridge M; Pemberton M; Rioja I; Seal GA; Shipley T; Singh O; Suckling CJ; Taylor J; Thomas P; Wilson DM; Lee K; Prinjha RK
    J Med Chem; 2016 Feb; 59(4):1370-87. PubMed ID: 26771203
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A miniaturized screen for inhibitors of Jumonji histone demethylases.
    Sakurai M; Rose NR; Schultz L; Quinn AM; Jadhav A; Ng SS; Oppermann U; Schofield CJ; Simeonov A
    Mol Biosyst; 2010 Feb; 6(2):357-64. PubMed ID: 20094655
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
    Hamada S; Suzuki T; Mino K; Koseki K; Oehme F; Flamme I; Ozasa H; Itoh Y; Ogasawara D; Komaarashi H; Kato A; Tsumoto H; Nakagawa H; Hasegawa M; Sasaki R; Mizukami T; Miyata N
    J Med Chem; 2010 Aug; 53(15):5629-38. PubMed ID: 20684604
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
    Chowdhury R; Yeoh KK; Tian YM; Hillringhaus L; Bagg EA; Rose NR; Leung IK; Li XS; Woon EC; Yang M; McDonough MA; King ON; Clifton IJ; Klose RJ; Claridge TD; Ratcliffe PJ; Schofield CJ; Kawamura A
    EMBO Rep; 2011 May; 12(5):463-9. PubMed ID: 21460794
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
    Kawamura A; Münzel M; Kojima T; Yapp C; Bhushan B; Goto Y; Tumber A; Katoh T; King ON; Passioura T; Walport LJ; Hatch SB; Madden S; Müller S; Brennan PE; Chowdhury R; Hopkinson RJ; Suga H; Schofield CJ
    Nat Commun; 2017 Apr; 8():14773. PubMed ID: 28382930
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.
    Islam MS; McDonough MA; Chowdhury R; Gault J; Khan A; Pires E; Schofield CJ
    J Biol Chem; 2019 Jul; 294(30):11637-11652. PubMed ID: 31147442
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.
    Woon EC; Demetriades M; Bagg EA; Aik W; Krylova SM; Ma JH; Chan M; Walport LJ; Wegman DW; Dack KN; McDonough MA; Krylov SN; Schofield CJ
    J Med Chem; 2012 Mar; 55(5):2173-84. PubMed ID: 22263962
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.