BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

997 related articles for article (PubMed ID: 20089133)

  • 1. Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.
    Kimura R; Devi L; Ohno M
    J Neurochem; 2010 Apr; 113(1):248-61. PubMed ID: 20089133
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice.
    Devi L; Ohno M
    Eur J Neurosci; 2010 Jan; 31(1):110-8. PubMed ID: 20092558
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease.
    Devi L; Ohno M
    Neuropsychopharmacology; 2012 Jan; 37(2):434-44. PubMed ID: 21900882
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stages.
    Devi L; Ohno M
    Neuroscience; 2015 Oct; 307():128-37. PubMed ID: 26314636
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A combination Alzheimer's therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice.
    Devi L; Ohno M
    Mol Brain; 2015 Mar; 8():19. PubMed ID: 25884928
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.
    Caccamo A; Branca C; Talboom JS; Shaw DM; Turner D; Ma L; Messina A; Huang Z; Wu J; Oddo S
    J Neurosci; 2015 Oct; 35(41):14042-56. PubMed ID: 26468204
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice.
    Devi L; Ohno M
    PLoS One; 2010 Sep; 5(9):e12974. PubMed ID: 20886088
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression.
    Devi L; Tang J; Ohno M
    Curr Alzheimer Res; 2015; 12(1):13-21. PubMed ID: 25523425
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease.
    Devi L; Ohno M
    Transl Psychiatry; 2013 Jul; 3(7):e284. PubMed ID: 23880880
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1).
    Giusti-Rodríguez P; Gao J; Gräff J; Rei D; Soda T; Tsai LH
    J Neurosci; 2011 Nov; 31(44):15751-6. PubMed ID: 22049418
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
    Ohno M; Chang L; Tseng W; Oakley H; Citron M; Klein WL; Vassar R; Disterhoft JF
    Eur J Neurosci; 2006 Jan; 23(1):251-60. PubMed ID: 16420434
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence.
    Kindy MS; Yu J; Zhu H; El-Amouri SS; Hook V; Hook GR
    J Alzheimers Dis; 2012; 29(4):827-40. PubMed ID: 22337825
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice.
    Devi L; Ohno M
    Neurobiol Dis; 2012 Jan; 45(1):417-24. PubMed ID: 21933711
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease Mice.
    Jeong YJ; Kang GY; Kwon JH; Choi HD; Pack JK; Kim N; Lee YS; Lee HJ
    Curr Alzheimer Res; 2015; 12(5):481-92. PubMed ID: 26017559
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level.
    Sadleir KR; Eimer WA; Cole SL; Vassar R
    Mol Neurodegener; 2015 Jan; 10():1. PubMed ID: 25567526
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Combination strategy employing BACE1 inhibitor and memantine to boost cognitive benefits in Alzheimer's disease therapy.
    Tarif AMM; Huhe H; Ohno M
    Psychopharmacology (Berl); 2024 May; 241(5):975-986. PubMed ID: 38197930
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
    Andrew RJ; Fernandez CG; Stanley M; Jiang H; Nguyen P; Rice RC; Buggia-Prévot V; De Rossi P; Vetrivel KS; Lamb R; Argemi A; Allaert ES; Rathbun EM; Krause SV; Wagner SL; Parent AT; Holtzman DM; Thinakaran G
    Proc Natl Acad Sci U S A; 2017 Nov; 114(45):E9665-E9674. PubMed ID: 29078331
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
    Li S; Hou H; Mori T; Sawmiller D; Smith A; Tian J; Wang Y; Giunta B; Sanberg PR; Zhang S; Tan J
    Sci Rep; 2015 Jun; 5():11322. PubMed ID: 26091071
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases.
    Cai Z; Wang C; He W; Chen Y
    Curr Alzheimer Res; 2018; 15(11):1045-1052. PubMed ID: 29962345
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.
    Saura CA; Chen G; Malkani S; Choi SY; Takahashi RH; Zhang D; Gouras GK; Kirkwood A; Morris RG; Shen J
    J Neurosci; 2005 Jul; 25(29):6755-64. PubMed ID: 16033885
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 50.